Hippocampal pyramidal cells and aging in the human: A quantitative study of neuronal loss in sectors CA1 to CA4
A number of investigators have proposed that hippocampal pathology contributes to the memory impairment seen in normal aging. The published morphometric studies of aging-associated quantitative changes in pyramidal cells in human hippocampus have yielded somewhat inconsistent results. We measured th...
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| Veröffentlicht in: | Experimental neurology 1986-10, Vol.94 (1), p.29-40 |
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| creator | Mani, Ranjit B. Lohr, James B. Jeste, Dilip V. |
| description | A number of investigators have proposed that hippocampal pathology contributes to the memory impairment seen in normal aging. The published morphometric studies of aging-associated quantitative changes in pyramidal cells in human hippocampus have yielded somewhat inconsistent results. We measured the volume, pyramidal cell density, and neuronal and nuclear cross-sectional areas in sectors CA1 through CA4 in right and left hippocampi from the brains of 23 normal subjects (age range 4 to 98 years) in the Yakovlev Collection. All four hippocampal sectors tended to show a decline in volume and pyramidal cell density with age, but the degree of neuronal loss was statistically significant only in CA4. The aging-related cell loss did not appear to be linear, but was most obvious after age 65. Elderly subjects had 19% (CA1), 16% (CA2), 17% (CA3), and 25% (CA4) lower mean pyramidal cell density compared with subjects under age 65. The relatively greater neuronal loss in CA4 could possibly be related to its high catecholaminergic innervation. |
| doi_str_mv | 10.1016/0014-4886(86)90269-4 |
| format | Article |
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The published morphometric studies of aging-associated quantitative changes in pyramidal cells in human hippocampus have yielded somewhat inconsistent results. We measured the volume, pyramidal cell density, and neuronal and nuclear cross-sectional areas in sectors CA1 through CA4 in right and left hippocampi from the brains of 23 normal subjects (age range 4 to 98 years) in the Yakovlev Collection. All four hippocampal sectors tended to show a decline in volume and pyramidal cell density with age, but the degree of neuronal loss was statistically significant only in CA4. The aging-related cell loss did not appear to be linear, but was most obvious after age 65. Elderly subjects had 19% (CA1), 16% (CA2), 17% (CA3), and 25% (CA4) lower mean pyramidal cell density compared with subjects under age 65. 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The published morphometric studies of aging-associated quantitative changes in pyramidal cells in human hippocampus have yielded somewhat inconsistent results. We measured the volume, pyramidal cell density, and neuronal and nuclear cross-sectional areas in sectors CA1 through CA4 in right and left hippocampi from the brains of 23 normal subjects (age range 4 to 98 years) in the Yakovlev Collection. All four hippocampal sectors tended to show a decline in volume and pyramidal cell density with age, but the degree of neuronal loss was statistically significant only in CA4. The aging-related cell loss did not appear to be linear, but was most obvious after age 65. Elderly subjects had 19% (CA1), 16% (CA2), 17% (CA3), and 25% (CA4) lower mean pyramidal cell density compared with subjects under age 65. The relatively greater neuronal loss in CA4 could possibly be related to its high catecholaminergic innervation.</description><subject>Activity levels. Psychomotricity</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - growth & development</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Neurons - cytology</subject><subject>Other techniques and industries</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Pyramidal Tracts - growth & development</subject><subject>Pyramidal Tracts - pathology</subject><subject>Theories</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxYMo67r6DRRyENFDa6WTzh8PwjCoKyx40XNIp5PdSHfSm3QvzLc37QxzdCFQgfq9ouo9hF4T-EiA8E8AhDVMSv5e8g8KWq4a9gRdElDQtIzCU3R5Rp6jF6X8AQDFWnGBLqjoZCu7S5Suwzwna6bZjHg-ZDOFof6sG8eCTRywuQ3xFoeIlzuH79bJxM94h-9XE5ewmCU8OFyWdTjg5HF0a06xysdUyqYpzi4pF7zfEbykWthL9MybsbhXp3qFfn_7-mt_3dz8_P5jv7tpbEfapel77wW3DnrBiSIUjFQ9UdZwKlvDeieHwVPXMsIHC4Z0Eqzy4LtWUiN8R6_Qu-PcOaf71ZVFT6FsV5no0lq0EMAUcPEoSFinKBcbyI6gzfW67Lyec5hMPmgCegtEb27rzW1d379ANKuyN6f5az-54Sw6JVD7b099U6wZfTbRhnLGJO0qCY9jQIXiFftyxFz19iG4rIsNLlo3hFyz0EMK_1_3L4r3swI</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>Mani, Ranjit B.</creator><creator>Lohr, James B.</creator><creator>Jeste, Dilip V.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19861001</creationdate><title>Hippocampal pyramidal cells and aging in the human: A quantitative study of neuronal loss in sectors CA1 to CA4</title><author>Mani, Ranjit B. ; Lohr, James B. ; Jeste, Dilip V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-bbff76ce0b7619130a89b19ca6382a4be8ddf3e2416dc0a1580c9f0f5283a7f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Activity levels. Psychomotricity</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus - growth & development</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Neurons - cytology</topic><topic>Other techniques and industries</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Pyramidal Tracts - growth & development</topic><topic>Pyramidal Tracts - pathology</topic><topic>Theories</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mani, Ranjit B.</creatorcontrib><creatorcontrib>Lohr, James B.</creatorcontrib><creatorcontrib>Jeste, Dilip V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mani, Ranjit B.</au><au>Lohr, James B.</au><au>Jeste, Dilip V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hippocampal pyramidal cells and aging in the human: A quantitative study of neuronal loss in sectors CA1 to CA4</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>1986-10-01</date><risdate>1986</risdate><volume>94</volume><issue>1</issue><spage>29</spage><epage>40</epage><pages>29-40</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>A number of investigators have proposed that hippocampal pathology contributes to the memory impairment seen in normal aging. The published morphometric studies of aging-associated quantitative changes in pyramidal cells in human hippocampus have yielded somewhat inconsistent results. We measured the volume, pyramidal cell density, and neuronal and nuclear cross-sectional areas in sectors CA1 through CA4 in right and left hippocampi from the brains of 23 normal subjects (age range 4 to 98 years) in the Yakovlev Collection. All four hippocampal sectors tended to show a decline in volume and pyramidal cell density with age, but the degree of neuronal loss was statistically significant only in CA4. The aging-related cell loss did not appear to be linear, but was most obvious after age 65. Elderly subjects had 19% (CA1), 16% (CA2), 17% (CA3), and 25% (CA4) lower mean pyramidal cell density compared with subjects under age 65. The relatively greater neuronal loss in CA4 could possibly be related to its high catecholaminergic innervation.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>3758285</pmid><doi>10.1016/0014-4886(86)90269-4</doi><tpages>12</tpages></addata></record> |
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| subjects | Activity levels. Psychomotricity Adolescent Adult Aged Aged, 80 and over Aging Applied sciences Biological and medical sciences Child Child, Preschool Exact sciences and technology Fundamental and applied biological sciences. Psychology Hippocampus - growth & development Hippocampus - pathology Humans Middle Aged Neurons - cytology Other techniques and industries Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyramidal Tracts - growth & development Pyramidal Tracts - pathology Theories |
| title | Hippocampal pyramidal cells and aging in the human: A quantitative study of neuronal loss in sectors CA1 to CA4 |
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