Protective Immunity against Human Carcinoembryonic Antigen (CEA) Induced by an Oral DNA Vaccine in CEA-transgenic Mice

Peripheral T-cell tolerance toward human carcinoembryonic self-antigen (CEA) was broken in CEA-transgenic C57BL/6J mice by an oral CEA-based DNA vaccine. This vaccine, delivered by the live, attenuated AroA − strain of Salmonella typhimurium (SL7207), induced tumor-protective immunity mediated by MH...

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Veröffentlicht in:	Clinical cancer research 2001-03, Vol.7 (3), p.856s-864s
Hauptverfasser:	RONG XIANG, SILLETTI, Steve, LODE, Holger N, DOLMAN, Carrie S, RUEHLMANN, J. Michael, NIETHAMMER, Andreas G, PERTL, Ursula, GILLIES, Stephen D, PRIMUS, F. James, REISFELD, Ralph A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - metabolism Biological and medical sciences Cancer Vaccines Carcinoembryonic Antigen - metabolism Cell Adhesion Molecules - metabolism Colonic Neoplasms - metabolism Cytokines - metabolism Epithelial Cell Adhesion Molecule Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Host-tumor relations. Immunology. Biological markers Humans Immunoblotting Intercellular Adhesion Molecule-1 - metabolism Interferon-gamma - metabolism Interleukin-12 - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Plasmids - metabolism Recombinant Fusion Proteins - metabolism Transfection Tumor Cells, Cultured Tumors Up-Regulation Vaccines, DNA
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