Why Ppr1p is a weak activator of transcription

Upon uracil depletion, the transcriptional activator Ppr1p stimulates expression of the Saccharomyces cerevisiae URA3 gene only four-fold. We performed a split-ubiquitin screen with Tup1p as bait, and we found that the global repressor Tup1p interacts with the transcriptional activator Ppr1p both in...

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Veröffentlicht in:	FEBS letters 2001-04, Vol.494 (1), p.64-68
Hauptverfasser:	Pätzold, Andreas J, Lehming, Norbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Cub, C-terminal half of ubiquitin DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism FOA, 5-fluoro-orotic acid Fungal Proteins - genetics Gene Expression Regulation, Fungal GFP, green fluorescent protein HA, hemagglutinin Nub, N-terminal half of ubiquitin Nuclear Proteins Ppr1p Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Repressor Proteins - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Split-ubiquitin Trans-Activators - genetics Trans-Activators - metabolism Transcription Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Tup1p UBPs, ubiquitin-specific proteases URA3
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