Lupus anti‐DNA autoantibodies cross‐react with a glomerular structural protein: a case for tissue injury by molecular mimicry

Anti‐DNA autoantibodies are the hallmark of human and murine systemic lupus erythematosus (SLE), an autoimmune rheumatic disease of unknown etiology. Some of these antibodies are believed to be pathogenic for kidney tissue and to initiate immune glomerulonephritis. However, the mechanisms by which a...

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Veröffentlicht in:	European journal of immunology 2001-04, Vol.31 (4), p.1221-1227
Hauptverfasser:	Mostoslavsky, Gustavo, Fischel, Ruth, Yachimovich, Nurit, Yarkoni, Yuval, Rosenmann, Eliezer, Monestier, Marc, Baniyash, Michal, Eilat, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinin - immunology Actinin - metabolism Animals Antibodies, Antinuclear - immunology Antibodies, Monoclonal - immunology B-Lymphocytes Cross Reactions - immunology Cross‐reaction Fluorescent Antibody Technique, Indirect Gene Deletion Genes, RAG-1 - genetics Hybridomas Kidney Glomerulus - chemistry Kidney Glomerulus - immunology Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Lupus Erythematosus, Systemic - pathology Lupus glomerulonephritis Lupus Nephritis - immunology Lupus Nephritis - metabolism Lupus Nephritis - pathology MALDI Mice Mice, Knockout Microscopy, Electron Molecular Mimicry RAG‐1 mice Rats Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization α‐actinin
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