Exercise Combined With Continuous Passive Motion or Slider Board Therapy Compared With Exercise Only: A Randomized Controlled Trial of Patients Following Total Knee Arthroplasty

The primary purpose of this randomized controlled trial was to determine which method of mobilization - (1) standardized exercises (SE) and continuous passive motion (CPM), (2) SE and slider board (SB) therapy, using an inexpensive, nontechnical device that requires minimal knee active range of moti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Physical therapy 2001-04, Vol.81 (4), p.1029-1037
Hauptverfasser: Beaupré, L A, Davies, D M, Jones, C A, Cinats, J G
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1037
container_issue 4
container_start_page 1029
container_title Physical therapy
container_volume 81
creator Beaupré, L A
Davies, D M
Jones, C A
Cinats, J G
description The primary purpose of this randomized controlled trial was to determine which method of mobilization - (1) standardized exercises (SE) and continuous passive motion (CPM), (2) SE and slider board (SB) therapy, using an inexpensive, nontechnical device that requires minimal knee active range of motion (ROM), or (3) SE alone-achieved the maximum degree of knee ROM in the fIrst 6 months following primary total knee arthroplasty (TKA). The secondary purpose was to compare health-related quality of life among these 3 groups. The subjects were 120 patients (n=40/group) who received a TEA at a teaching hospital between June 1997 and July 1998 and who agreed to participate in the study. Subjects were examined preoperatively, at discharge, and at 3 and 6 months after surgery. The examination consisted of measurement of knee ROM and completion of the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). The 3 treatment groups were similar with respect to age, sex, and diagnosis at the start of the study. There were no differences in knee ROM or in WOMAC Osteoarthritis Index or SF-36 scores at any of the measurement intervals. The rate of postoperative complications also was not different among the groups. When postoperative rehabilitation regimens that focus on early mobilization of the patient are used, adjunct ROM therapies (CPM and SB) that are added to daily SE sessions are not required. Six months after TEA, patients attain a satisfactory level of knee ROM and function.
doi_str_mv 10.1093/ptj/81.4.1029
format Article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_77047751</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A74010431</galeid><sourcerecordid>A74010431</sourcerecordid><originalsourceid>FETCH-LOGICAL-c496t-a0676998283948f346781e877a77f3d457b50e06cdf341a01786cecd51ffafb33</originalsourceid><addsrcrecordid>eNqFksGO0zAQhiMEYsvCkSuyOHAiu3bsxg63Uu0CYlERFHG03GTSunLsYDvslrfiDXHUQgWqhHywx_PNP_LvybKnBF8QXNHLPm4vBblgKSqqe9mETKnIS16w-9kEY0ryChf0LHsUwhZjTDirHmZnhBRVKTCdZD-v7sDXOgCau26lLTToq46bFNmo7eCGgD6qEPR3QB9c1M4i59Fnoxvw6LVTvkHLDXjV78b6Xvnf9X9kF9bsXqEZ-qRs4zr9IwGjtnfGpOPSa2WQa1OTqMHGgK5Twt1qu0ZLF1PuvQVAMx833vVGhbh7nD1olQnw5LCfZ1-ur5bzt_nN4s27-ewmr1lVxlzhkpdVJQpBKyZaykouCAjOFectbdiUr6YYcFk3KUdUckaUNdTNlLStaleUnmcv9rq9d98GCFF2OtRgjLKQbJGcY8b5lPwXJIJiRooigc__Abdu8DY9QqYsIRWpygS93ENrZUBq27roVb0Gm1w2zkKr0_WMM0wwo2Pz_ASeVgOdrk_xf8snJMJdrMfvWINMDs4Xp-Rr70Lw0Mre6075nSRYjvMn0_xJQSST4_wl_tnhicOqg-ZIHwbu2H-j15tb7UGGThmT8GKU2vtx1PsFTFHl9w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223119196</pqid></control><display><type>article</type><title>Exercise Combined With Continuous Passive Motion or Slider Board Therapy Compared With Exercise Only: A Randomized Controlled Trial of Patients Following Total Knee Arthroplasty</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB Electronic Journals Library</source><creator>Beaupré, L A ; Davies, D M ; Jones, C A ; Cinats, J G</creator><creatorcontrib>Beaupré, L A ; Davies, D M ; Jones, C A ; Cinats, J G</creatorcontrib><description>The primary purpose of this randomized controlled trial was to determine which method of mobilization - (1) standardized exercises (SE) and continuous passive motion (CPM), (2) SE and slider board (SB) therapy, using an inexpensive, nontechnical device that requires minimal knee active range of motion (ROM), or (3) SE alone-achieved the maximum degree of knee ROM in the fIrst 6 months following primary total knee arthroplasty (TKA). The secondary purpose was to compare health-related quality of life among these 3 groups. The subjects were 120 patients (n=40/group) who received a TEA at a teaching hospital between June 1997 and July 1998 and who agreed to participate in the study. Subjects were examined preoperatively, at discharge, and at 3 and 6 months after surgery. The examination consisted of measurement of knee ROM and completion of the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). The 3 treatment groups were similar with respect to age, sex, and diagnosis at the start of the study. There were no differences in knee ROM or in WOMAC Osteoarthritis Index or SF-36 scores at any of the measurement intervals. The rate of postoperative complications also was not different among the groups. When postoperative rehabilitation regimens that focus on early mobilization of the patient are used, adjunct ROM therapies (CPM and SB) that are added to daily SE sessions are not required. Six months after TEA, patients attain a satisfactory level of knee ROM and function.</description><identifier>ISSN: 0031-9023</identifier><identifier>EISSN: 1538-6724</identifier><identifier>DOI: 10.1093/ptj/81.4.1029</identifier><identifier>PMID: 11296803</identifier><language>eng</language><publisher>United States: American Physical Therapy Association</publisher><subject>Activities of Daily Living ; Aged ; Arthroplasty, Replacement, Knee - psychology ; Arthroplasty, Replacement, Knee - rehabilitation ; Artificial knee ; Care and treatment ; Clinical trials ; Combined Modality Therapy ; Equipment and supplies ; Exercise ; Exercise Therapy - instrumentation ; Exercise Therapy - methods ; Female ; Follow-Up Studies ; Humans ; Knee ; Knee prostheses ; Male ; Motion Therapy, Continuous Passive - methods ; Motion Therapy, Continuous Passive - psychology ; Osteoarthritis, Knee - physiopathology ; Osteoarthritis, Knee - surgery ; Physical therapy ; Quality of Life ; Range of Motion, Articular ; Recovery of Function ; Single-Blind Method ; Surgery ; Therapeutics, Physiological ; Treatment Outcome</subject><ispartof>Physical therapy, 2001-04, Vol.81 (4), p.1029-1037</ispartof><rights>COPYRIGHT 2001 Oxford University Press</rights><rights>COPYRIGHT 2001 Oxford University Press</rights><rights>Copyright American Physical Therapy Association Apr 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-a0676998283948f346781e877a77f3d457b50e06cdf341a01786cecd51ffafb33</citedby><cites>FETCH-LOGICAL-c496t-a0676998283948f346781e877a77f3d457b50e06cdf341a01786cecd51ffafb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11296803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beaupré, L A</creatorcontrib><creatorcontrib>Davies, D M</creatorcontrib><creatorcontrib>Jones, C A</creatorcontrib><creatorcontrib>Cinats, J G</creatorcontrib><title>Exercise Combined With Continuous Passive Motion or Slider Board Therapy Compared With Exercise Only: A Randomized Controlled Trial of Patients Following Total Knee Arthroplasty</title><title>Physical therapy</title><addtitle>Phys Ther</addtitle><description>The primary purpose of this randomized controlled trial was to determine which method of mobilization - (1) standardized exercises (SE) and continuous passive motion (CPM), (2) SE and slider board (SB) therapy, using an inexpensive, nontechnical device that requires minimal knee active range of motion (ROM), or (3) SE alone-achieved the maximum degree of knee ROM in the fIrst 6 months following primary total knee arthroplasty (TKA). The secondary purpose was to compare health-related quality of life among these 3 groups. The subjects were 120 patients (n=40/group) who received a TEA at a teaching hospital between June 1997 and July 1998 and who agreed to participate in the study. Subjects were examined preoperatively, at discharge, and at 3 and 6 months after surgery. The examination consisted of measurement of knee ROM and completion of the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). The 3 treatment groups were similar with respect to age, sex, and diagnosis at the start of the study. There were no differences in knee ROM or in WOMAC Osteoarthritis Index or SF-36 scores at any of the measurement intervals. The rate of postoperative complications also was not different among the groups. When postoperative rehabilitation regimens that focus on early mobilization of the patient are used, adjunct ROM therapies (CPM and SB) that are added to daily SE sessions are not required. Six months after TEA, patients attain a satisfactory level of knee ROM and function.</description><subject>Activities of Daily Living</subject><subject>Aged</subject><subject>Arthroplasty, Replacement, Knee - psychology</subject><subject>Arthroplasty, Replacement, Knee - rehabilitation</subject><subject>Artificial knee</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Combined Modality Therapy</subject><subject>Equipment and supplies</subject><subject>Exercise</subject><subject>Exercise Therapy - instrumentation</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Knee</subject><subject>Knee prostheses</subject><subject>Male</subject><subject>Motion Therapy, Continuous Passive - methods</subject><subject>Motion Therapy, Continuous Passive - psychology</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Osteoarthritis, Knee - surgery</subject><subject>Physical therapy</subject><subject>Quality of Life</subject><subject>Range of Motion, Articular</subject><subject>Recovery of Function</subject><subject>Single-Blind Method</subject><subject>Surgery</subject><subject>Therapeutics, Physiological</subject><subject>Treatment Outcome</subject><issn>0031-9023</issn><issn>1538-6724</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFksGO0zAQhiMEYsvCkSuyOHAiu3bsxg63Uu0CYlERFHG03GTSunLsYDvslrfiDXHUQgWqhHywx_PNP_LvybKnBF8QXNHLPm4vBblgKSqqe9mETKnIS16w-9kEY0ryChf0LHsUwhZjTDirHmZnhBRVKTCdZD-v7sDXOgCau26lLTToq46bFNmo7eCGgD6qEPR3QB9c1M4i59Fnoxvw6LVTvkHLDXjV78b6Xvnf9X9kF9bsXqEZ-qRs4zr9IwGjtnfGpOPSa2WQa1OTqMHGgK5Twt1qu0ZLF1PuvQVAMx833vVGhbh7nD1olQnw5LCfZ1-ur5bzt_nN4s27-ewmr1lVxlzhkpdVJQpBKyZaykouCAjOFectbdiUr6YYcFk3KUdUckaUNdTNlLStaleUnmcv9rq9d98GCFF2OtRgjLKQbJGcY8b5lPwXJIJiRooigc__Abdu8DY9QqYsIRWpygS93ENrZUBq27roVb0Gm1w2zkKr0_WMM0wwo2Pz_ASeVgOdrk_xf8snJMJdrMfvWINMDs4Xp-Rr70Lw0Mre6075nSRYjvMn0_xJQSST4_wl_tnhicOqg-ZIHwbu2H-j15tb7UGGThmT8GKU2vtx1PsFTFHl9w</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Beaupré, L A</creator><creator>Davies, D M</creator><creator>Jones, C A</creator><creator>Cinats, J G</creator><general>American Physical Therapy Association</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Exercise Combined With Continuous Passive Motion or Slider Board Therapy Compared With Exercise Only: A Randomized Controlled Trial of Patients Following Total Knee Arthroplasty</title><author>Beaupré, L A ; Davies, D M ; Jones, C A ; Cinats, J G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-a0676998283948f346781e877a77f3d457b50e06cdf341a01786cecd51ffafb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Activities of Daily Living</topic><topic>Aged</topic><topic>Arthroplasty, Replacement, Knee - psychology</topic><topic>Arthroplasty, Replacement, Knee - rehabilitation</topic><topic>Artificial knee</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Combined Modality Therapy</topic><topic>Equipment and supplies</topic><topic>Exercise</topic><topic>Exercise Therapy - instrumentation</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Knee</topic><topic>Knee prostheses</topic><topic>Male</topic><topic>Motion Therapy, Continuous Passive - methods</topic><topic>Motion Therapy, Continuous Passive - psychology</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>Osteoarthritis, Knee - surgery</topic><topic>Physical therapy</topic><topic>Quality of Life</topic><topic>Range of Motion, Articular</topic><topic>Recovery of Function</topic><topic>Single-Blind Method</topic><topic>Surgery</topic><topic>Therapeutics, Physiological</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beaupré, L A</creatorcontrib><creatorcontrib>Davies, D M</creatorcontrib><creatorcontrib>Jones, C A</creatorcontrib><creatorcontrib>Cinats, J G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Career &amp; Technical Education Database</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Physical Education Index</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Homework Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest Healthcare Administration Database</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Research Library</collection><collection>ProQuest Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Physical therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beaupré, L A</au><au>Davies, D M</au><au>Jones, C A</au><au>Cinats, J G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise Combined With Continuous Passive Motion or Slider Board Therapy Compared With Exercise Only: A Randomized Controlled Trial of Patients Following Total Knee Arthroplasty</atitle><jtitle>Physical therapy</jtitle><addtitle>Phys Ther</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>81</volume><issue>4</issue><spage>1029</spage><epage>1037</epage><pages>1029-1037</pages><issn>0031-9023</issn><eissn>1538-6724</eissn><abstract>The primary purpose of this randomized controlled trial was to determine which method of mobilization - (1) standardized exercises (SE) and continuous passive motion (CPM), (2) SE and slider board (SB) therapy, using an inexpensive, nontechnical device that requires minimal knee active range of motion (ROM), or (3) SE alone-achieved the maximum degree of knee ROM in the fIrst 6 months following primary total knee arthroplasty (TKA). The secondary purpose was to compare health-related quality of life among these 3 groups. The subjects were 120 patients (n=40/group) who received a TEA at a teaching hospital between June 1997 and July 1998 and who agreed to participate in the study. Subjects were examined preoperatively, at discharge, and at 3 and 6 months after surgery. The examination consisted of measurement of knee ROM and completion of the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). The 3 treatment groups were similar with respect to age, sex, and diagnosis at the start of the study. There were no differences in knee ROM or in WOMAC Osteoarthritis Index or SF-36 scores at any of the measurement intervals. The rate of postoperative complications also was not different among the groups. When postoperative rehabilitation regimens that focus on early mobilization of the patient are used, adjunct ROM therapies (CPM and SB) that are added to daily SE sessions are not required. Six months after TEA, patients attain a satisfactory level of knee ROM and function.</abstract><cop>United States</cop><pub>American Physical Therapy Association</pub><pmid>11296803</pmid><doi>10.1093/ptj/81.4.1029</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0031-9023
ispartof Physical therapy, 2001-04, Vol.81 (4), p.1029-1037
issn 0031-9023
1538-6724
language eng
recordid cdi_proquest_miscellaneous_77047751
source Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB Electronic Journals Library
subjects Activities of Daily Living
Aged
Arthroplasty, Replacement, Knee - psychology
Arthroplasty, Replacement, Knee - rehabilitation
Artificial knee
Care and treatment
Clinical trials
Combined Modality Therapy
Equipment and supplies
Exercise
Exercise Therapy - instrumentation
Exercise Therapy - methods
Female
Follow-Up Studies
Humans
Knee
Knee prostheses
Male
Motion Therapy, Continuous Passive - methods
Motion Therapy, Continuous Passive - psychology
Osteoarthritis, Knee - physiopathology
Osteoarthritis, Knee - surgery
Physical therapy
Quality of Life
Range of Motion, Articular
Recovery of Function
Single-Blind Method
Surgery
Therapeutics, Physiological
Treatment Outcome
title Exercise Combined With Continuous Passive Motion or Slider Board Therapy Compared With Exercise Only: A Randomized Controlled Trial of Patients Following Total Knee Arthroplasty
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T16%3A30%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exercise%20Combined%20With%20Continuous%20Passive%20Motion%20or%20Slider%20Board%20Therapy%20Compared%20With%20Exercise%20Only:%20A%20Randomized%20Controlled%20Trial%20of%20Patients%20Following%20Total%20Knee%20Arthroplasty&rft.jtitle=Physical%20therapy&rft.au=Beaupr%C3%A9,%20L%20A&rft.date=2001-04-01&rft.volume=81&rft.issue=4&rft.spage=1029&rft.epage=1037&rft.pages=1029-1037&rft.issn=0031-9023&rft.eissn=1538-6724&rft_id=info:doi/10.1093/ptj/81.4.1029&rft_dat=%3Cgale_proqu%3EA74010431%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223119196&rft_id=info:pmid/11296803&rft_galeid=A74010431&rfr_iscdi=true