The use of inverse phase gas chromatography to study the change of surface energy of amorphous lactose as a function of relative humidity and the processes of collapse and crystallisation

The purpose of this study was to assess the effect of relative humidity (RH) on the surface energy of amorphous lactose. Two samples of amorphous lactose were investigated; a spray dried 100% amorphous material and a ball milled sample of crystalline lactose. The milled sample had less than 1% amorp...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	International journal of pharmaceutics 2001-04, Vol.217 (1), p.45-56
Hauptverfasser:	Newell, Helen E, Buckton, Graham, Butler, David A, Thielmann, Frank, Williams, Daryl R
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Amorphous Analysis Biological and medical sciences Chromatography, Gas - instrumentation Collapse Crystallization General pharmacology Glass transition Humidity Inverse phase gas chromatography Lactose - chemistry Medical sciences Pharmacology. Drug treatments Surface energy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!