Chronic antral gastritis in duodenal ulcer: natural history and treatment with prostaglandin E1
The natural history of chronic antral gastritis in relation to the healing of duodenal ulcer and its response to treatment, if any, are unknown. We performed a double-blind controlled trial using an oral prostaglandin E1, misoprostol, in 229 patients with active duodenal ulcer randomized to receive...
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Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1986-11, Vol.91 (5), p.1095-1101 |
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creator | WAI-MO HUI SHIU-KUM LAM TAT-KUEN CHOI HO, J MA-TAI NG, M LUI, I CHING-LUNG LAI SUK-FONG LOK, A WAN-YEE LAU GAH-PANG POON CHOI, S |
description | The natural history of chronic antral gastritis in relation to the healing of duodenal ulcer and its response to treatment, if any, are unknown. We performed a double-blind controlled trial using an oral prostaglandin E1, misoprostol, in 229 patients with active duodenal ulcer randomized to receive placebo (n = 76), misoprostol 200 micrograms (n = 77), or misoprostol 300 micrograms (n = 76), q.i.d. orally. Healing of duodenal ulcer was assessed biweekly up to 12 wk by endoscopy, during which procedures at least two antral and two fundal biopsy specimens were taken. The activity and the degree of chronic inflammation of gastritis, as assessed histologically by the infiltration of polymorphs and chronic inflammatory cells, respectively, was graded blindly by two pathologists as nil, mild, moderate, or severe. Before treatment, 99% of patients had chronic antral gastritis and 1.5% had chronic fundal gastritis. In the placebo group, healed duodenal ulcer was associated with significantly (p less than 0.01, life table analysis) higher incidence of improvement of the activity of the antral gastritis (nil or mild as endpoint) than unhealed ulcer (30% vs. 4% at week 8). Irrespective of whether duodenal ulcer was healed or unhealed, significantly (p less than 0.01) more patients on misoprostol (50% at week 8) showed improvement (nil or mild as endpoint) than the placebo group. The degree of chronic inflammation of the antral gastritis showed similar significant changes in favor of misoprostol. Smoking and alcohol intake had no significant effect on the improvement of chronic antral gastritis. In conclusion, healing of duodenal ulcer was associated with improvement of the activity of chronic antral gastritis, which, as shown for the first time, could be further enhanced by a therapeutic agent--prostaglandin E1. |
doi_str_mv | 10.1016/S0016-5085(86)80003-8 |
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We performed a double-blind controlled trial using an oral prostaglandin E1, misoprostol, in 229 patients with active duodenal ulcer randomized to receive placebo (n = 76), misoprostol 200 micrograms (n = 77), or misoprostol 300 micrograms (n = 76), q.i.d. orally. Healing of duodenal ulcer was assessed biweekly up to 12 wk by endoscopy, during which procedures at least two antral and two fundal biopsy specimens were taken. The activity and the degree of chronic inflammation of gastritis, as assessed histologically by the infiltration of polymorphs and chronic inflammatory cells, respectively, was graded blindly by two pathologists as nil, mild, moderate, or severe. Before treatment, 99% of patients had chronic antral gastritis and 1.5% had chronic fundal gastritis. In the placebo group, healed duodenal ulcer was associated with significantly (p less than 0.01, life table analysis) higher incidence of improvement of the activity of the antral gastritis (nil or mild as endpoint) than unhealed ulcer (30% vs. 4% at week 8). Irrespective of whether duodenal ulcer was healed or unhealed, significantly (p less than 0.01) more patients on misoprostol (50% at week 8) showed improvement (nil or mild as endpoint) than the placebo group. The degree of chronic inflammation of the antral gastritis showed similar significant changes in favor of misoprostol. Smoking and alcohol intake had no significant effect on the improvement of chronic antral gastritis. In conclusion, healing of duodenal ulcer was associated with improvement of the activity of chronic antral gastritis, which, as shown for the first time, could be further enhanced by a therapeutic agent--prostaglandin E1.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/S0016-5085(86)80003-8</identifier><identifier>PMID: 3093305</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Adult ; Alprostadil - analogs & derivatives ; Alprostadil - therapeutic use ; Applied sciences ; Biological and medical sciences ; Chronic Disease ; Digestive system ; Double-Blind Method ; Duodenal Ulcer - complications ; Duodenal Ulcer - drug therapy ; Exact sciences and technology ; Female ; Gastritis - complications ; Gastritis - drug therapy ; Humans ; Male ; Medical sciences ; Misoprostol ; Other techniques and industries ; Pharmacology. Drug treatments ; Placebos ; Prostaglandins E - therapeutic use ; Random Allocation</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1986-11, Vol.91 (5), p.1095-1101</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8290533$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8354483$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3093305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WAI-MO HUI</creatorcontrib><creatorcontrib>SHIU-KUM LAM</creatorcontrib><creatorcontrib>TAT-KUEN CHOI</creatorcontrib><creatorcontrib>HO, J</creatorcontrib><creatorcontrib>MA-TAI NG, M</creatorcontrib><creatorcontrib>LUI, I</creatorcontrib><creatorcontrib>CHING-LUNG LAI</creatorcontrib><creatorcontrib>SUK-FONG LOK, A</creatorcontrib><creatorcontrib>WAN-YEE LAU</creatorcontrib><creatorcontrib>GAH-PANG POON</creatorcontrib><creatorcontrib>CHOI, S</creatorcontrib><title>Chronic antral gastritis in duodenal ulcer: natural history and treatment with prostaglandin E1</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>The natural history of chronic antral gastritis in relation to the healing of duodenal ulcer and its response to treatment, if any, are unknown. We performed a double-blind controlled trial using an oral prostaglandin E1, misoprostol, in 229 patients with active duodenal ulcer randomized to receive placebo (n = 76), misoprostol 200 micrograms (n = 77), or misoprostol 300 micrograms (n = 76), q.i.d. orally. Healing of duodenal ulcer was assessed biweekly up to 12 wk by endoscopy, during which procedures at least two antral and two fundal biopsy specimens were taken. The activity and the degree of chronic inflammation of gastritis, as assessed histologically by the infiltration of polymorphs and chronic inflammatory cells, respectively, was graded blindly by two pathologists as nil, mild, moderate, or severe. Before treatment, 99% of patients had chronic antral gastritis and 1.5% had chronic fundal gastritis. In the placebo group, healed duodenal ulcer was associated with significantly (p less than 0.01, life table analysis) higher incidence of improvement of the activity of the antral gastritis (nil or mild as endpoint) than unhealed ulcer (30% vs. 4% at week 8). Irrespective of whether duodenal ulcer was healed or unhealed, significantly (p less than 0.01) more patients on misoprostol (50% at week 8) showed improvement (nil or mild as endpoint) than the placebo group. The degree of chronic inflammation of the antral gastritis showed similar significant changes in favor of misoprostol. Smoking and alcohol intake had no significant effect on the improvement of chronic antral gastritis. In conclusion, healing of duodenal ulcer was associated with improvement of the activity of chronic antral gastritis, which, as shown for the first time, could be further enhanced by a therapeutic agent--prostaglandin E1.</description><subject>Adult</subject><subject>Alprostadil - analogs & derivatives</subject><subject>Alprostadil - therapeutic use</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Digestive system</subject><subject>Double-Blind Method</subject><subject>Duodenal Ulcer - complications</subject><subject>Duodenal Ulcer - drug therapy</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Gastritis - complications</subject><subject>Gastritis - drug therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Misoprostol</subject><subject>Other techniques and industries</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Placebos</topic><topic>Prostaglandins E - therapeutic use</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WAI-MO HUI</creatorcontrib><creatorcontrib>SHIU-KUM LAM</creatorcontrib><creatorcontrib>TAT-KUEN CHOI</creatorcontrib><creatorcontrib>HO, J</creatorcontrib><creatorcontrib>MA-TAI NG, M</creatorcontrib><creatorcontrib>LUI, I</creatorcontrib><creatorcontrib>CHING-LUNG LAI</creatorcontrib><creatorcontrib>SUK-FONG LOK, A</creatorcontrib><creatorcontrib>WAN-YEE LAU</creatorcontrib><creatorcontrib>GAH-PANG POON</creatorcontrib><creatorcontrib>CHOI, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WAI-MO HUI</au><au>SHIU-KUM LAM</au><au>TAT-KUEN CHOI</au><au>HO, J</au><au>MA-TAI NG, M</au><au>LUI, I</au><au>CHING-LUNG LAI</au><au>SUK-FONG LOK, A</au><au>WAN-YEE LAU</au><au>GAH-PANG POON</au><au>CHOI, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic antral gastritis in duodenal ulcer: natural history and treatment with prostaglandin E1</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1986-11-01</date><risdate>1986</risdate><volume>91</volume><issue>5</issue><spage>1095</spage><epage>1101</epage><pages>1095-1101</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>The natural history of chronic antral gastritis in relation to the healing of duodenal ulcer and its response to treatment, if any, are unknown. We performed a double-blind controlled trial using an oral prostaglandin E1, misoprostol, in 229 patients with active duodenal ulcer randomized to receive placebo (n = 76), misoprostol 200 micrograms (n = 77), or misoprostol 300 micrograms (n = 76), q.i.d. orally. Healing of duodenal ulcer was assessed biweekly up to 12 wk by endoscopy, during which procedures at least two antral and two fundal biopsy specimens were taken. The activity and the degree of chronic inflammation of gastritis, as assessed histologically by the infiltration of polymorphs and chronic inflammatory cells, respectively, was graded blindly by two pathologists as nil, mild, moderate, or severe. Before treatment, 99% of patients had chronic antral gastritis and 1.5% had chronic fundal gastritis. In the placebo group, healed duodenal ulcer was associated with significantly (p less than 0.01, life table analysis) higher incidence of improvement of the activity of the antral gastritis (nil or mild as endpoint) than unhealed ulcer (30% vs. 4% at week 8). Irrespective of whether duodenal ulcer was healed or unhealed, significantly (p less than 0.01) more patients on misoprostol (50% at week 8) showed improvement (nil or mild as endpoint) than the placebo group. The degree of chronic inflammation of the antral gastritis showed similar significant changes in favor of misoprostol. Smoking and alcohol intake had no significant effect on the improvement of chronic antral gastritis. In conclusion, healing of duodenal ulcer was associated with improvement of the activity of chronic antral gastritis, which, as shown for the first time, could be further enhanced by a therapeutic agent--prostaglandin E1.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>3093305</pmid><doi>10.1016/S0016-5085(86)80003-8</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Alprostadil - analogs & derivatives Alprostadil - therapeutic use Applied sciences Biological and medical sciences Chronic Disease Digestive system Double-Blind Method Duodenal Ulcer - complications Duodenal Ulcer - drug therapy Exact sciences and technology Female Gastritis - complications Gastritis - drug therapy Humans Male Medical sciences Misoprostol Other techniques and industries Pharmacology. Drug treatments Placebos Prostaglandins E - therapeutic use Random Allocation |
title | Chronic antral gastritis in duodenal ulcer: natural history and treatment with prostaglandin E1 |
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