Indomethacin therapy abrogates the prostaglandin-mediated suppression of natural killer activity in tumor-bearing mice and prevents tumor metastasis

We have shown earlier that a decline in splenic natural killer (NK) activity during the development of transplanted or spontaneous tumors in mice results from an inactivation of NK lineage cells, mediated by prostaglandins (primarily PGE 2) secreted by NK suppressor cells of the monocyte-macrophage...

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Veröffentlicht in:	Cellular immunology 1986-04, Vol.99 (1), p.108-118
Hauptverfasser:	Lala, P.K., Parhar, R.S., Singh, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Cytotoxicity, Immunologic - drug effects Dinoprostone Exact sciences and technology Indomethacin - therapeutic use Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - immunology Mammary Neoplasms, Experimental - pathology Mice Mice, Inbred C3H - immunology Neoplasm Metastasis - prevention & control Neoplasm Transplantation Other techniques and industries Prostaglandins - biosynthesis Prostaglandins - pharmacology Prostaglandins E - pharmacology T-Lymphocytes, Regulatory - metabolism
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