Induction of HL-60 cell differentiation by 3-deaza-(±)-aristeromycin, an inhibitor of S-adenosylhomocysteine hydrolase

The metabolically stable inhibitor of S-adenosylhomocysteine hydrolase (AdoHcyase), 3-deaza-(+/-)-aristeromycin (dzAri) has recently been shown to induce differentiation in HL-60 cells. The present study was undertaken to characterize the cytostatic, cytotoxic, and differentiation inducing propertie...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1986-11, Vol.46 (11), p.5469-5472
Hauptverfasser:	AARBAKKE, J, MIURA, G. A, PRYTZ, P. S, BESSESEN, A, SLØRDAL, L, GORDON, R. K, CHIANG, P. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosylhomocysteinase Antineoplastic agents Biological and medical sciences Cell Cycle - drug effects Cell Differentiation - drug effects Cell Line Cell Survival - drug effects General aspects Humans Hydrolases - antagonists & inhibitors Leukemia, Myeloid, Acute Medical sciences Pharmacology. Drug treatments S-Adenosylhomocysteine - metabolism S-Adenosylmethionine - metabolism
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