Increasing mean airway pressure reduces functional MRI (fMRI) signal in the primary visual cortex
Changes in both blood flow and blood oxygenation determine the functional MRI (fMRI) signal. In the present study factors responsible for blood oxygenation (e.g., FiO 2) were held constant so that changes in pixel count would above all reflect changes in regional cerebral blood flow (rCBF). Continuo...
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| Veröffentlicht in: | Magnetic resonance imaging 2001, Vol.19 (1), p.7-11 |
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| creator | Lorenz, Ingo H. Kolbitsch, Christian Hörmann, Christoph Schocke, Michael Kremser, Christian Zschiegner, Fritz Felber, Stephan Benzer, Arnulf |
| description | Changes in both blood flow and blood oxygenation determine the functional MRI (fMRI) signal. In the present study factors responsible for blood oxygenation (e.g., FiO
2) were held constant so that changes in pixel count would above all reflect changes in regional cerebral blood flow (rCBF). Continuous positive airway pressure (CPAP) breathing at 12 cm H
2O, which was previously shown to influence rCBF, was applied in human volunteers (
n = 19) to investigate the sensitivity of fMRI for changes in rCBF caused by increased mean airway pressure. Increasing the mean airway pressure decreased the pixel count in the primary visual cortex (median (range)): baseline: 219 (58–425) pixels vs. CPAP (12 cm H
2O): 92 (0–262) pixels). These findings indicate that fMRI is sensitive to detect a reduced rCBF-response in the primary visual cortex. The underlying mechanism is likely to be a reduced basal rCBF due to constriction and/or compression of postcapillary venoles during CPAP breathing. These findings are important for interpreting fMRI results in awake and in artificially respirated patients, in whom positive airway pressure is used to improve pulmonary function during the diagnostic procedure. |
| doi_str_mv | 10.1016/S0730-725X(00)00229-0 |
| format | Article |
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2) were held constant so that changes in pixel count would above all reflect changes in regional cerebral blood flow (rCBF). Continuous positive airway pressure (CPAP) breathing at 12 cm H
2O, which was previously shown to influence rCBF, was applied in human volunteers (
n = 19) to investigate the sensitivity of fMRI for changes in rCBF caused by increased mean airway pressure. Increasing the mean airway pressure decreased the pixel count in the primary visual cortex (median (range)): baseline: 219 (58–425) pixels vs. CPAP (12 cm H
2O): 92 (0–262) pixels). These findings indicate that fMRI is sensitive to detect a reduced rCBF-response in the primary visual cortex. The underlying mechanism is likely to be a reduced basal rCBF due to constriction and/or compression of postcapillary venoles during CPAP breathing. These findings are important for interpreting fMRI results in awake and in artificially respirated patients, in whom positive airway pressure is used to improve pulmonary function during the diagnostic procedure.</description><identifier>ISSN: 0730-725X</identifier><identifier>EISSN: 1873-5894</identifier><identifier>DOI: 10.1016/S0730-725X(00)00229-0</identifier><identifier>PMID: 11295340</identifier><identifier>CODEN: MRIMDQ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Cerebrovascular Circulation - physiology ; continuous positive airway pressure (CPAP) ; fMRI signal ; Humans ; Investigative techniques of respiratory function ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Nervous system ; Oxygen - blood ; Oxygen - physiology ; Positive-Pressure Respiration ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Reference Values ; Respiration, Artificial ; Visual Cortex - anatomy & histology ; Visual Cortex - physiology ; Volunteers</subject><ispartof>Magnetic resonance imaging, 2001, Vol.19 (1), p.7-11</ispartof><rights>2001 Elsevier Science Inc.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-3e6dcba2cf5147ea4db6839fb2d54c83c35bc39ef86d6a45a2234434538cb3233</citedby><cites>FETCH-LOGICAL-c389t-3e6dcba2cf5147ea4db6839fb2d54c83c35bc39ef86d6a45a2234434538cb3233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0730-725X(00)00229-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=938737$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11295340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lorenz, Ingo H.</creatorcontrib><creatorcontrib>Kolbitsch, Christian</creatorcontrib><creatorcontrib>Hörmann, Christoph</creatorcontrib><creatorcontrib>Schocke, Michael</creatorcontrib><creatorcontrib>Kremser, Christian</creatorcontrib><creatorcontrib>Zschiegner, Fritz</creatorcontrib><creatorcontrib>Felber, Stephan</creatorcontrib><creatorcontrib>Benzer, Arnulf</creatorcontrib><title>Increasing mean airway pressure reduces functional MRI (fMRI) signal in the primary visual cortex</title><title>Magnetic resonance imaging</title><addtitle>Magn Reson Imaging</addtitle><description>Changes in both blood flow and blood oxygenation determine the functional MRI (fMRI) signal. In the present study factors responsible for blood oxygenation (e.g., FiO
2) were held constant so that changes in pixel count would above all reflect changes in regional cerebral blood flow (rCBF). Continuous positive airway pressure (CPAP) breathing at 12 cm H
2O, which was previously shown to influence rCBF, was applied in human volunteers (
n = 19) to investigate the sensitivity of fMRI for changes in rCBF caused by increased mean airway pressure. Increasing the mean airway pressure decreased the pixel count in the primary visual cortex (median (range)): baseline: 219 (58–425) pixels vs. CPAP (12 cm H
2O): 92 (0–262) pixels). These findings indicate that fMRI is sensitive to detect a reduced rCBF-response in the primary visual cortex. The underlying mechanism is likely to be a reduced basal rCBF due to constriction and/or compression of postcapillary venoles during CPAP breathing. These findings are important for interpreting fMRI results in awake and in artificially respirated patients, in whom positive airway pressure is used to improve pulmonary function during the diagnostic procedure.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>continuous positive airway pressure (CPAP)</subject><subject>fMRI signal</subject><subject>Humans</subject><subject>Investigative techniques of respiratory function</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Oxygen - blood</subject><subject>Oxygen - physiology</subject><subject>Positive-Pressure Respiration</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Reference Values</subject><subject>Respiration, Artificial</subject><subject>Visual Cortex - anatomy & histology</subject><subject>Visual Cortex - physiology</subject><subject>Volunteers</subject><issn>0730-725X</issn><issn>1873-5894</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1r1UAQhhdR7Gn1JygLgrQX0cl-5ONKpFg9UBH8AO-WzWRSV3I2dSep9t-7pyfUS292YHje2eEZIZ6V8KqEsnr9BWoNRa3s91OAMwCl2gIeiE3Z1LqwTWseis09ciSOmX8CgFXaPhZHZalaqw1shN9GTOQ5xCu5Ix-lD-m3v5XXiZiXRDJRvyCxHJaIc5iiH-XHz1t5OuT3THK42ndClPMPyqGw8-lW3gRechenNNOfJ-LR4Eemp2s9Ed8u3n09_1Bcfnq_PX97WaBu2rnQVPXYeYWDLU1N3vRd1eh26FRvDTYate1QtzQ0VV95Y71S2hhtrG6w00rrE_HyMPc6Tb8W4tntAiONo480LezqGoyB1mTQHkBME3Oiwa17uxLc3q27c-v24hyAu3PrIOeerx8s3Y76f6lVZgZerIBn9OOQfMTA91yr82nqTL05UJRl3ARKjjFQROpDIpxdP4X_LPIXrwyWBw</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Lorenz, Ingo H.</creator><creator>Kolbitsch, Christian</creator><creator>Hörmann, Christoph</creator><creator>Schocke, Michael</creator><creator>Kremser, Christian</creator><creator>Zschiegner, Fritz</creator><creator>Felber, Stephan</creator><creator>Benzer, Arnulf</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Increasing mean airway pressure reduces functional MRI (fMRI) signal in the primary visual cortex</title><author>Lorenz, Ingo H. ; Kolbitsch, Christian ; Hörmann, Christoph ; Schocke, Michael ; Kremser, Christian ; Zschiegner, Fritz ; Felber, Stephan ; Benzer, Arnulf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-3e6dcba2cf5147ea4db6839fb2d54c83c35bc39ef86d6a45a2234434538cb3233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>continuous positive airway pressure (CPAP)</topic><topic>fMRI signal</topic><topic>Humans</topic><topic>Investigative techniques of respiratory function</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Oxygen - blood</topic><topic>Oxygen - physiology</topic><topic>Positive-Pressure Respiration</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Reference Values</topic><topic>Respiration, Artificial</topic><topic>Visual Cortex - anatomy & histology</topic><topic>Visual Cortex - physiology</topic><topic>Volunteers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lorenz, Ingo H.</creatorcontrib><creatorcontrib>Kolbitsch, Christian</creatorcontrib><creatorcontrib>Hörmann, Christoph</creatorcontrib><creatorcontrib>Schocke, Michael</creatorcontrib><creatorcontrib>Kremser, Christian</creatorcontrib><creatorcontrib>Zschiegner, Fritz</creatorcontrib><creatorcontrib>Felber, Stephan</creatorcontrib><creatorcontrib>Benzer, Arnulf</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorenz, Ingo H.</au><au>Kolbitsch, Christian</au><au>Hörmann, Christoph</au><au>Schocke, Michael</au><au>Kremser, Christian</au><au>Zschiegner, Fritz</au><au>Felber, Stephan</au><au>Benzer, Arnulf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increasing mean airway pressure reduces functional MRI (fMRI) signal in the primary visual cortex</atitle><jtitle>Magnetic resonance imaging</jtitle><addtitle>Magn Reson Imaging</addtitle><date>2001</date><risdate>2001</risdate><volume>19</volume><issue>1</issue><spage>7</spage><epage>11</epage><pages>7-11</pages><issn>0730-725X</issn><eissn>1873-5894</eissn><coden>MRIMDQ</coden><abstract>Changes in both blood flow and blood oxygenation determine the functional MRI (fMRI) signal. In the present study factors responsible for blood oxygenation (e.g., FiO
2) were held constant so that changes in pixel count would above all reflect changes in regional cerebral blood flow (rCBF). Continuous positive airway pressure (CPAP) breathing at 12 cm H
2O, which was previously shown to influence rCBF, was applied in human volunteers (
n = 19) to investigate the sensitivity of fMRI for changes in rCBF caused by increased mean airway pressure. Increasing the mean airway pressure decreased the pixel count in the primary visual cortex (median (range)): baseline: 219 (58–425) pixels vs. CPAP (12 cm H
2O): 92 (0–262) pixels). These findings indicate that fMRI is sensitive to detect a reduced rCBF-response in the primary visual cortex. The underlying mechanism is likely to be a reduced basal rCBF due to constriction and/or compression of postcapillary venoles during CPAP breathing. These findings are important for interpreting fMRI results in awake and in artificially respirated patients, in whom positive airway pressure is used to improve pulmonary function during the diagnostic procedure.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11295340</pmid><doi>10.1016/S0730-725X(00)00229-0</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Cerebrovascular Circulation - physiology continuous positive airway pressure (CPAP) fMRI signal Humans Investigative techniques of respiratory function Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Nervous system Oxygen - blood Oxygen - physiology Positive-Pressure Respiration Radiodiagnosis. Nmr imagery. Nmr spectrometry Reference Values Respiration, Artificial Visual Cortex - anatomy & histology Visual Cortex - physiology Volunteers |
| title | Increasing mean airway pressure reduces functional MRI (fMRI) signal in the primary visual cortex |
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