Scl 70 autoantibodies from scleroderma patients recognize a 95 kDa protein identified as DNA topoisomerase I

Sera of patients suffering from the autoimmune disease progressive systemic sclerosis (PSS) are known to contain autoantibodies which have been reported to recognize a 70 kDa antigenic protein, designated the Scl 70 antigen. By immunoblotting of nuclear extracts from HeLa cells with sera from sclero...

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Veröffentlicht in:	Chromosoma 1986-01, Vol.94 (2), p.132-138
Hauptverfasser:	GULDNER, H.-H, SZOSTECKI, C, VOSBERG, H.-P, LAKOMEK, H.-J, PENNER, E, BAUTZ, F. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Antibody Complex - analysis Autoantibodies - immunology Biological and medical sciences DNA Topoisomerases, Type I - immunology Epitopes - analysis Fluorescent Antibody Technique Humans Immunodiffusion Medical sciences Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - enzymology Scleroderma, Systemic - immunology
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