The -238 tumor necrosis factor-α promoter polymorphism is associated with decreased susceptibility to cancers
We investigated the potential association of tumor necrosis factor-α (TNF-α) promoter polymorphisms with cancers. The study included 169 patients with gastric cancer, uterine cervical cancer, colorectal cancer, or renal cell carcinoma and 92 healthy controls. The -308 and -238 polymorphisms in the T...
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| Veröffentlicht in: | Cancer letters 2001-05, Vol.166 (1), p.41-46 |
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| container_title | Cancer letters |
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| creator | Jang, Won Hee Yang, Young-Il Yea, Sung Su Lee, Youn Jae Chun, Jin Ho Kim, Hyeong-In Kim, Mi Seong Paik, Kye-Hyung |
| description | We investigated the potential association of tumor necrosis factor-α (TNF-α) promoter polymorphisms with cancers. The study included 169 patients with gastric cancer, uterine cervical cancer, colorectal cancer, or renal cell carcinoma and 92 healthy controls. The -308 and -238 polymorphisms in the TNF-α promoter were analyzed by PCR-restriction fragment length polymorphism (RFLP). The proportion of individuals carrying the TNF-238A allele was significantly lower in the cancer group than in the control group. The odds ratio for cancer in subjects with the TNF-238A allele was 0.25 (95% CI, 0.10–0.64). No association was found between the -308 polymorphism and cancers. These results suggest that the -238A allele has a protective function against cancers. |
| doi_str_mv | 10.1016/S0304-3835(01)00438-4 |
| format | Article |
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The study included 169 patients with gastric cancer, uterine cervical cancer, colorectal cancer, or renal cell carcinoma and 92 healthy controls. The -308 and -238 polymorphisms in the TNF-α promoter were analyzed by PCR-restriction fragment length polymorphism (RFLP). The proportion of individuals carrying the TNF-238A allele was significantly lower in the cancer group than in the control group. The odds ratio for cancer in subjects with the TNF-238A allele was 0.25 (95% CI, 0.10–0.64). No association was found between the -308 polymorphism and cancers. These results suggest that the -238A allele has a protective function against cancers.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(01)00438-4</identifier><identifier>PMID: 11295285</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Cancer ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Medical sciences ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasms - genetics ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Tumor Necrosis Factor-alpha - genetics ; Tumor necrosis factor-α ; Tumors</subject><ispartof>Cancer letters, 2001-05, Vol.166 (1), p.41-46</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-b032e09994f7d73ff1a310b084f187c73a5bf4b72f0c9205f88afb7ecdb68d753</citedby><cites>FETCH-LOGICAL-c419t-b032e09994f7d73ff1a310b084f187c73a5bf4b72f0c9205f88afb7ecdb68d753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3835(01)00438-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1023391$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11295285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jang, Won Hee</creatorcontrib><creatorcontrib>Yang, Young-Il</creatorcontrib><creatorcontrib>Yea, Sung Su</creatorcontrib><creatorcontrib>Lee, Youn Jae</creatorcontrib><creatorcontrib>Chun, Jin Ho</creatorcontrib><creatorcontrib>Kim, Hyeong-In</creatorcontrib><creatorcontrib>Kim, Mi Seong</creatorcontrib><creatorcontrib>Paik, Kye-Hyung</creatorcontrib><title>The -238 tumor necrosis factor-α promoter polymorphism is associated with decreased susceptibility to cancers</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>We investigated the potential association of tumor necrosis factor-α (TNF-α) promoter polymorphisms with cancers. The study included 169 patients with gastric cancer, uterine cervical cancer, colorectal cancer, or renal cell carcinoma and 92 healthy controls. The -308 and -238 polymorphisms in the TNF-α promoter were analyzed by PCR-restriction fragment length polymorphism (RFLP). The proportion of individuals carrying the TNF-238A allele was significantly lower in the cancer group than in the control group. The odds ratio for cancer in subjects with the TNF-238A allele was 0.25 (95% CI, 0.10–0.64). No association was found between the -308 polymorphism and cancers. These results suggest that the -238A allele has a protective function against cancers.</description><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasms - genetics</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor necrosis factor-α</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMuKFDEUhoMoTjv6CEoWIrooPbl1UiuRwRsMuHBch1QqoSNVnTInpfRj-SI-k-npRt25Cge-_-Q_HyGPGbxkwLavPoMA2Qkj1HNgLwCkMJ28QzbMaN7p3sBdsvmDXJAHiF8BQEmt7pMLxnivuFEbsr_ZBdpxYWhd51zoPviSMSGNztdcul8_6VLynGsodMnToTHLLuFMG-IQs0-uhpH-SHVHx5YNDtuIK_qw1DSkKdUDrZl6t_eh4ENyL7oJw6Pze0m-vHt7c_Whu_70_uPVm-vOS9bXbgDBA_R9L6MetYiROcFgACNju89r4dQQ5aB5BN9zUNEYFwcd_DhszaiVuCTPTntb-W9rwGrn1CpNk9uHvKLVGiRsNW-gOoHHs7GEaJeSZlcOloE9ira3ou3RogVmb0Vb2XJPzh-swxzGv6mz2QY8PQMOvZtiaQIS_rOdC9Gzhr0-YaHZ-J5CsehTaK7GVIKvdszpP01-A_BgnC8</recordid><startdate>20010510</startdate><enddate>20010510</enddate><creator>Jang, Won Hee</creator><creator>Yang, Young-Il</creator><creator>Yea, Sung Su</creator><creator>Lee, Youn Jae</creator><creator>Chun, Jin Ho</creator><creator>Kim, Hyeong-In</creator><creator>Kim, Mi Seong</creator><creator>Paik, Kye-Hyung</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010510</creationdate><title>The -238 tumor necrosis factor-α promoter polymorphism is associated with decreased susceptibility to cancers</title><author>Jang, Won Hee ; Yang, Young-Il ; Yea, Sung Su ; Lee, Youn Jae ; Chun, Jin Ho ; Kim, Hyeong-In ; Kim, Mi Seong ; Paik, Kye-Hyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-b032e09994f7d73ff1a310b084f187c73a5bf4b72f0c9205f88afb7ecdb68d753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasms - genetics</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumor necrosis factor-α</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Won Hee</creatorcontrib><creatorcontrib>Yang, Young-Il</creatorcontrib><creatorcontrib>Yea, Sung Su</creatorcontrib><creatorcontrib>Lee, Youn Jae</creatorcontrib><creatorcontrib>Chun, Jin Ho</creatorcontrib><creatorcontrib>Kim, Hyeong-In</creatorcontrib><creatorcontrib>Kim, Mi Seong</creatorcontrib><creatorcontrib>Paik, Kye-Hyung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Won Hee</au><au>Yang, Young-Il</au><au>Yea, Sung Su</au><au>Lee, Youn Jae</au><au>Chun, Jin Ho</au><au>Kim, Hyeong-In</au><au>Kim, Mi Seong</au><au>Paik, Kye-Hyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The -238 tumor necrosis factor-α promoter polymorphism is associated with decreased susceptibility to cancers</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2001-05-10</date><risdate>2001</risdate><volume>166</volume><issue>1</issue><spage>41</spage><epage>46</epage><pages>41-46</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>We investigated the potential association of tumor necrosis factor-α (TNF-α) promoter polymorphisms with cancers. The study included 169 patients with gastric cancer, uterine cervical cancer, colorectal cancer, or renal cell carcinoma and 92 healthy controls. The -308 and -238 polymorphisms in the TNF-α promoter were analyzed by PCR-restriction fragment length polymorphism (RFLP). The proportion of individuals carrying the TNF-238A allele was significantly lower in the cancer group than in the control group. The odds ratio for cancer in subjects with the TNF-238A allele was 0.25 (95% CI, 0.10–0.64). No association was found between the -308 polymorphism and cancers. These results suggest that the -238A allele has a protective function against cancers.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11295285</pmid><doi>10.1016/S0304-3835(01)00438-4</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cancer letters, 2001-05, Vol.166 (1), p.41-46 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biological and medical sciences Cancer Gene Frequency Genetic Predisposition to Disease Genotype Humans Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - genetics Polymorphism Polymorphism, Genetic Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Promoter Regions, Genetic Tumor Necrosis Factor-alpha - genetics Tumor necrosis factor-α Tumors |
| title | The -238 tumor necrosis factor-α promoter polymorphism is associated with decreased susceptibility to cancers |
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