Bile acid–oligodeoxynucleotide conjugates: synthesis and liver excretion in rats
The synthesis of bile acid–oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid–oligodeoxynucleotide conjugates...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2001-04, Vol.11 (7), p.945-949 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Starke, Dieter Lischka, Kerstin Pagels, Peter Uhlmann, Eugen Kramer, Werner Wess, Günter Petzinger, Ernst |
| description | The synthesis of bile acid–oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid–oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides.
The synthesis of bile acid–oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid–oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides. |
| doi_str_mv | 10.1016/S0960-894X(01)00048-8 |
| format | Article |
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The synthesis of bile acid–oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid–oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/S0960-894X(01)00048-8</identifier><identifier>PMID: 11294397</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Bile Acids and Salts - chemistry ; Bile Acids and Salts - metabolism ; Bile Acids and Salts - pharmacokinetics ; Biological and medical sciences ; Hepatocytes - metabolism ; In Vitro Techniques ; Liver - metabolism ; Male ; Medical sciences ; Miscellaneous ; Oligodeoxyribonucleotides - chemistry ; Oligodeoxyribonucleotides - metabolism ; Oligodeoxyribonucleotides - pharmacokinetics ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar</subject><ispartof>Bioorganic & medicinal chemistry letters, 2001-04, Vol.11 (7), p.945-949</ispartof><rights>2001 Elsevier Science Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-7f9152a119a15d93e060fa36a40fb9454f8c1cea162f9d7f762ab0fae5f235293</citedby><cites>FETCH-LOGICAL-c389t-7f9152a119a15d93e060fa36a40fb9454f8c1cea162f9d7f762ab0fae5f235293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X01000488$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=931959$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11294397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Starke, Dieter</creatorcontrib><creatorcontrib>Lischka, Kerstin</creatorcontrib><creatorcontrib>Pagels, Peter</creatorcontrib><creatorcontrib>Uhlmann, Eugen</creatorcontrib><creatorcontrib>Kramer, Werner</creatorcontrib><creatorcontrib>Wess, Günter</creatorcontrib><creatorcontrib>Petzinger, Ernst</creatorcontrib><title>Bile acid–oligodeoxynucleotide conjugates: synthesis and liver excretion in rats</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>The synthesis of bile acid–oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid–oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides.
The synthesis of bile acid–oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid–oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides.</description><subject>Animals</subject><subject>Bile Acids and Salts - chemistry</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Bile Acids and Salts - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Hepatocytes - metabolism</subject><subject>In Vitro Techniques</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Oligodeoxyribonucleotides - chemistry</subject><subject>Oligodeoxyribonucleotides - metabolism</subject><subject>Oligodeoxyribonucleotides - pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M1qFTEUwPEgFnttfQRlQCi6GHvOJJmZuClaqhUKgh_gLuQmJzVlblKTmdK76zv4hj6Jc3svdekqm985OfwZe47wBgHb46-gWqh7JX68AnwNAKKv-0dsgaIVNRcgH7PFA9lnT0u5AkABQjxh-4iNElx1C_blfRioMja4P3e_0xAuk6N0u46THSiNwVFlU7yaLs1I5W1V1nH8SSWUykRXDeGGckW3NtMYUqxCrLIZyyHb82Yo9Gz3HrDvH86-nZ7XF58_fjp9d1Fb3qux7rxC2RhEZVA6xQla8Ia3RoBfKiGF7y1aMtg2XrnOd21jlrMg6RsuG8UP2NF273VOvyYqo16FYmkYTKQ0Fd11wJUUzQzlFtqcSsnk9XUOK5PXGkFvYur7mHpTSgPq-5i6n-de7D6Ylity_6Z29WbwcgdMsWbw2UQbyoNTHJXc3HmyVTTHuAmUdbGBoiUXMtlRuxT-c8hf6xuS4Q</recordid><startdate>20010409</startdate><enddate>20010409</enddate><creator>Starke, Dieter</creator><creator>Lischka, Kerstin</creator><creator>Pagels, Peter</creator><creator>Uhlmann, Eugen</creator><creator>Kramer, Werner</creator><creator>Wess, Günter</creator><creator>Petzinger, Ernst</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010409</creationdate><title>Bile acid–oligodeoxynucleotide conjugates: synthesis and liver excretion in rats</title><author>Starke, Dieter ; Lischka, Kerstin ; Pagels, Peter ; Uhlmann, Eugen ; Kramer, Werner ; Wess, Günter ; Petzinger, Ernst</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-7f9152a119a15d93e060fa36a40fb9454f8c1cea162f9d7f762ab0fae5f235293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Bile Acids and Salts - chemistry</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Bile Acids and Salts - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Hepatocytes - metabolism</topic><topic>In Vitro Techniques</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Oligodeoxyribonucleotides - chemistry</topic><topic>Oligodeoxyribonucleotides - metabolism</topic><topic>Oligodeoxyribonucleotides - pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Starke, Dieter</creatorcontrib><creatorcontrib>Lischka, Kerstin</creatorcontrib><creatorcontrib>Pagels, Peter</creatorcontrib><creatorcontrib>Uhlmann, Eugen</creatorcontrib><creatorcontrib>Kramer, Werner</creatorcontrib><creatorcontrib>Wess, Günter</creatorcontrib><creatorcontrib>Petzinger, Ernst</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Starke, Dieter</au><au>Lischka, Kerstin</au><au>Pagels, Peter</au><au>Uhlmann, Eugen</au><au>Kramer, Werner</au><au>Wess, Günter</au><au>Petzinger, Ernst</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bile acid–oligodeoxynucleotide conjugates: synthesis and liver excretion in rats</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2001-04-09</date><risdate>2001</risdate><volume>11</volume><issue>7</issue><spage>945</spage><epage>949</epage><pages>945-949</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>The synthesis of bile acid–oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid–oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides.
The synthesis of bile acid–oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid–oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11294397</pmid><doi>10.1016/S0960-894X(01)00048-8</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2001-04, Vol.11 (7), p.945-949 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Bile Acids and Salts - chemistry Bile Acids and Salts - metabolism Bile Acids and Salts - pharmacokinetics Biological and medical sciences Hepatocytes - metabolism In Vitro Techniques Liver - metabolism Male Medical sciences Miscellaneous Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Oligodeoxyribonucleotides - pharmacokinetics Pharmacology. Drug treatments Rats Rats, Wistar |
| title | Bile acid–oligodeoxynucleotide conjugates: synthesis and liver excretion in rats |
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