Developmental alterations in hepatic UDP-glucuronosyltransferase: A comparison of the kinetic properties of enzymes from adult sheep and fetal lambs

The kinetic properties of hepatic microsomal UDP-glucuronosyltransferase were studied in sheep in the perinatal period, using acetaminophen as the aglycone. Kinetic analyses indicated that activity at V max was significantly less in fetal microsomes (113, 135 or 141 days) as compared with the adult...

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Veröffentlicht in:	Biochemical pharmacology 1986-09, Vol.35 (18), p.3065-3070
Hauptverfasser:	Wang, Laurene H., Zakim, David, Rudolph, Abraham M., Benet, Leslie Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Enzymes and enzyme inhibitors Fetus - metabolism fetuses Fundamental and applied biological sciences. Psychology Gestational Age Glucuronosyltransferase - metabolism Kinetics liver Liver - enzymology Sheep Transferases UDP glucuronosyltransferase Uridine Diphosphate N-Acetylglucosamine - metabolism
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