Urinary neopterin reflects clinical activity in patients with rheumatoid arthritis
Neopterin is a marker for activation of cellular immunity. Urinary neopterin levels were measured in 106 patients with rheumatoid arthritis (RA) and in 45 patients with osteoarthritis. Levels were significantly higher in RA patients than in osteoarthritis patients and were strongly dependent on stag...
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| Veröffentlicht in: | Arthritis and rheumatism 1986-09, Vol.29 (9), p.1063-1070 |
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| container_end_page | 1070 |
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| container_issue | 9 |
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| container_title | Arthritis and rheumatism |
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| creator | Reibnegger, Gilbert Egg, Dietmar Fuchs, Dietmar Günther, Robert Hausen, Arno Werner, Ernst R. Wachter, Helmut |
| description | Neopterin is a marker for activation of cellular immunity. Urinary neopterin levels were measured in 106 patients with rheumatoid arthritis (RA) and in 45 patients with osteoarthritis. Levels were significantly higher in RA patients than in osteoarthritis patients and were strongly dependent on stage and activity of RA. Correlations with other laboratory parameters were weak. Multivariate analysis demonstrated that urinary neopterin levels reflected clinical activity better than did other laboratory findings. Thus, urinary neopterin determination might be useful in monitoring RA patients. |
| doi_str_mv | 10.1002/art.1780290902 |
| format | Article |
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Urinary neopterin levels were measured in 106 patients with rheumatoid arthritis (RA) and in 45 patients with osteoarthritis. Levels were significantly higher in RA patients than in osteoarthritis patients and were strongly dependent on stage and activity of RA. Correlations with other laboratory parameters were weak. Multivariate analysis demonstrated that urinary neopterin levels reflected clinical activity better than did other laboratory findings. 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Urinary neopterin levels were measured in 106 patients with rheumatoid arthritis (RA) and in 45 patients with osteoarthritis. Levels were significantly higher in RA patients than in osteoarthritis patients and were strongly dependent on stage and activity of RA. Correlations with other laboratory parameters were weak. Multivariate analysis demonstrated that urinary neopterin levels reflected clinical activity better than did other laboratory findings. Thus, urinary neopterin determination might be useful in monitoring RA patients.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>3753537</pmid><doi>10.1002/art.1780290902</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Arthritis and rheumatism, 1986-09, Vol.29 (9), p.1063-1070 |
| issn | 0004-3591 1529-0131 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Aged Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - urine Biological and medical sciences Biopterins - analogs & derivatives Biopterins - urine Blood Sedimentation C-Reactive Protein - blood Diseases of the osteoarticular system Female Humans Immunity, Cellular Inflammatory joint diseases Male Medical sciences Middle Aged Neopterin Osteoarthritis - urine Pteridines - urine Rheumatoid Factor - blood |
| title | Urinary neopterin reflects clinical activity in patients with rheumatoid arthritis |
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