The Activity of Immunoregulatory T Cells Mediating Active Tolerance Is Potentiated in Nonobese Diabetic Mice by an IL-4-Based Retroviral Gene Therapy

Splenocytes from nonobese diabetic mice overexpressing murine IL (mIL)-4 upon recombinant retrovirus infection lose their capacity to transfer diabetes to nonobese diabetic-scid recipients. Diabetes appeared in 0-20% of mice injected with mIL-4-transduced cells vs 80-100% of controls injected with b...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-04, Vol.166 (8), p.4973-4980
Hauptverfasser:	Yamamoto, Ana Maria, Chernajovsky, Yuti, Lepault, Francoise, Podhajcer, Osvaldo, Feldmann, Marc, Bach, Jean-Francois, Chatenoud, Lucienne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - genetics Adoptive Transfer Animals beta-Galactosidase - administration & dosage beta-Galactosidase - biosynthesis beta-Galactosidase - genetics Cell Movement - immunology Cells, Cultured Clone Cells Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - prevention & control Female Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - immunology Immune Tolerance - genetics Immunity, Active - genetics Interleukin-4 - administration & dosage Interleukin-4 - biosynthesis Interleukin-4 - genetics Islets of Langerhans - pathology L-Selectin - biosynthesis Lymphocyte Transfusion Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic Receptors, Antigen, T-Cell, alpha-beta - genetics Retroviridae - genetics Retroviridae - immunology Spleen - cytology Spleen - immunology Spleen - transplantation Spleen - virology T-Lymphocyte Subsets - enzymology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - transplantation T-Lymphocyte Subsets - virology Transgenes - immunology
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