Inhibition of antigen-receptor signaling by Platelet Endothelial Cell Adhesion Molecule-1 (CD31) requires functional ITIMs, SHP-2, and p56(lck)

Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1, CD31) is a 130-kd member of the immunoglobulin gene superfamily that is expressed on the surface of platelets, endothelial cells, myeloid cells, and certain lymphocyte subsets. PECAM-1 has recently been shown to contain functional immunorecepto...

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Veröffentlicht in:	Blood 2001-04, Vol.97 (8), p.2351-2357
Hauptverfasser:	Newman, D K, Hamilton, C, Newman, P J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Antibodies, Monoclonal - pharmacology Calcium Signaling - drug effects Calcium Signaling - physiology CD3 Complex - immunology CD3 Complex - physiology Chickens Humans Intracellular Signaling Peptides and Proteins Jurkat Cells - drug effects Jurkat Cells - enzymology Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - deficiency Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - physiology Phosphorylation Platelet Endothelial Cell Adhesion Molecule-1 - chemistry Platelet Endothelial Cell Adhesion Molecule-1 - genetics Platelet Endothelial Cell Adhesion Molecule-1 - physiology Protein Phosphatase 2 Protein Processing, Post-Translational Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatase, Non-Receptor Type 6 Protein Tyrosine Phosphatases - physiology Receptors, Antigen, T-Cell - physiology Recombinant Fusion Proteins - physiology SH2 Domain-Containing Protein Tyrosine Phosphatases src Homology Domains Structure-Activity Relationship Transfection
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