Karyotype of the abortus in recurrent miscarriage
Objective: To assess the chromosomal aberrations in the abortus in recurrent miscarriage and the live birth rate after a euploid or aneuploid miscarriage. Design: Retrospective analysis. Setting: Tertiary referral unit in university hospital. Patient(s): One hundred sixty-seven patients with 3 to 16...
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| Veröffentlicht in: | Fertility and sterility 2001-04, Vol.75 (4), p.678-682 |
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| container_title | Fertility and sterility |
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| creator | Carp, Howard Toder, Vladimir Aviram, Ayala Daniely, Michal Mashiach, Shlomo Barkai, Gad |
| description | Objective: To assess the chromosomal aberrations in the abortus in recurrent miscarriage and the live birth rate after a euploid or aneuploid miscarriage.
Design: Retrospective analysis.
Setting: Tertiary referral unit in university hospital.
Patient(s): One hundred sixty-seven patients with 3 to 16 miscarriages before 20 weeks.
Intervention(s): Material collected at curettage from 167 abortuses was analyzed by standard G-banding techniques.
Main Outcome Measure(s): The incidence of aberrations and the outcome of the subsequent pregnancy were assessed according to the embryonic karyotype.
Result(s): In this study 125 specimens were successfully karyotyped. Of these, 29% (36 of 125) had chromosome aberrations; 94% of the aberrations were aneuploidy, and 6% were structural. The most prevalent anomalies were chromosome 16, 18, and 21 trisomies, triploidy, and monosomy X. After an aneuploid miscarriage, there was a 68% subsequent live birth rate (13 of 19) compared to the 41% (16 of 39) rate after a euploid abortion.
Conclusion(s): The low (29%) incidence of aberrations indicates that alternative mechanisms may be responsible for the majority of recurrent miscarriages. These figures provide a basis for assessing the efficacy of therapy for recurrent miscarriage. If further studies confirm that patients with karyotypically abnormal fetuses have a good prognosis, an informed decision can be made as to whether further investigations and treatment should be undertaken. |
| doi_str_mv | 10.1016/S0015-0282(00)01801-X |
| format | Article |
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Design: Retrospective analysis.
Setting: Tertiary referral unit in university hospital.
Patient(s): One hundred sixty-seven patients with 3 to 16 miscarriages before 20 weeks.
Intervention(s): Material collected at curettage from 167 abortuses was analyzed by standard G-banding techniques.
Main Outcome Measure(s): The incidence of aberrations and the outcome of the subsequent pregnancy were assessed according to the embryonic karyotype.
Result(s): In this study 125 specimens were successfully karyotyped. Of these, 29% (36 of 125) had chromosome aberrations; 94% of the aberrations were aneuploidy, and 6% were structural. The most prevalent anomalies were chromosome 16, 18, and 21 trisomies, triploidy, and monosomy X. After an aneuploid miscarriage, there was a 68% subsequent live birth rate (13 of 19) compared to the 41% (16 of 39) rate after a euploid abortion.
Conclusion(s): The low (29%) incidence of aberrations indicates that alternative mechanisms may be responsible for the majority of recurrent miscarriages. These figures provide a basis for assessing the efficacy of therapy for recurrent miscarriage. If further studies confirm that patients with karyotypically abnormal fetuses have a good prognosis, an informed decision can be made as to whether further investigations and treatment should be undertaken.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(00)01801-X</identifier><identifier>PMID: 11287018</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Abortion ; Abortion, Habitual - genetics ; Adult ; Aneuploidy ; Biological and medical sciences ; Chromosome Aberrations ; Diseases of mother, fetus and pregnancy ; Female ; Fetus ; Gynecology. Andrology. Obstetrics ; Hospitals, University ; Humans ; Infant, Newborn ; Israel ; karyotype ; Karyotyping ; Medical sciences ; Middle Aged ; Monosomy ; Odds Ratio ; Polyploidy ; Pregnancy ; pregnancy loss ; Pregnancy Outcome ; Pregnancy. Fetus. Placenta ; recurrent miscarriage ; Retrospective Studies ; Sex Chromosome Aberrations ; Translocation, Genetic ; Trisomy ; X Chromosome</subject><ispartof>Fertility and sterility, 2001-04, Vol.75 (4), p.678-682</ispartof><rights>2001 American Society for Reproductive Medicine</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-dc23a32eb2ece3f0fcec425220bb32a22f27d28356442c7fd03015f6286f14203</citedby><cites>FETCH-LOGICAL-c502t-dc23a32eb2ece3f0fcec425220bb32a22f27d28356442c7fd03015f6286f14203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(00)01801-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=953485$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11287018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carp, Howard</creatorcontrib><creatorcontrib>Toder, Vladimir</creatorcontrib><creatorcontrib>Aviram, Ayala</creatorcontrib><creatorcontrib>Daniely, Michal</creatorcontrib><creatorcontrib>Mashiach, Shlomo</creatorcontrib><creatorcontrib>Barkai, Gad</creatorcontrib><title>Karyotype of the abortus in recurrent miscarriage</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective: To assess the chromosomal aberrations in the abortus in recurrent miscarriage and the live birth rate after a euploid or aneuploid miscarriage.
Design: Retrospective analysis.
Setting: Tertiary referral unit in university hospital.
Patient(s): One hundred sixty-seven patients with 3 to 16 miscarriages before 20 weeks.
Intervention(s): Material collected at curettage from 167 abortuses was analyzed by standard G-banding techniques.
Main Outcome Measure(s): The incidence of aberrations and the outcome of the subsequent pregnancy were assessed according to the embryonic karyotype.
Result(s): In this study 125 specimens were successfully karyotyped. Of these, 29% (36 of 125) had chromosome aberrations; 94% of the aberrations were aneuploidy, and 6% were structural. The most prevalent anomalies were chromosome 16, 18, and 21 trisomies, triploidy, and monosomy X. After an aneuploid miscarriage, there was a 68% subsequent live birth rate (13 of 19) compared to the 41% (16 of 39) rate after a euploid abortion.
Conclusion(s): The low (29%) incidence of aberrations indicates that alternative mechanisms may be responsible for the majority of recurrent miscarriages. These figures provide a basis for assessing the efficacy of therapy for recurrent miscarriage. If further studies confirm that patients with karyotypically abnormal fetuses have a good prognosis, an informed decision can be made as to whether further investigations and treatment should be undertaken.</description><subject>Abortion</subject><subject>Abortion, Habitual - genetics</subject><subject>Adult</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Chromosome Aberrations</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fetus</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Israel</subject><subject>karyotype</subject><subject>Karyotyping</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monosomy</subject><subject>Odds Ratio</subject><subject>Polyploidy</subject><subject>Pregnancy</subject><subject>pregnancy loss</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>recurrent miscarriage</subject><subject>Retrospective Studies</subject><subject>Sex Chromosome Aberrations</subject><subject>Translocation, Genetic</subject><subject>Trisomy</subject><subject>X Chromosome</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo7vrxE5SCIHqoTiZNW08i4hcueFBhbyFNJxrZbdekFfbfm_1gPXqay_POvPMwdsThggPPL18BuEwBSzwDOAdeAk_HW2zIpcxTmUuxzYYbZMD2QvgCgJwXuMsGnGNZxMyQ8Wft5203n1HS2qT7pERXre_6kLgm8WR676npkqkLRnvv9AcdsB2rJ4EO13Ofvd_fvd0-pqOXh6fbm1FqJGCX1gaFFkgVkiFhwRoyGUpEqCqBGtFiUWMpZJ5laApbg4htbY5lbnmGIPbZ6WrvzLffPYVOLUrQZKIbavugigKEhKsignIFGt-G4MmqmXfT-JbioBau1NKVWohQAGrpSo1j7nh9oK-mVP-l1nIicLIGdPx-Yr1ujAsb7kqKrJSRul5RFGX8OPIqGEeNodpFf52qW_dPkV9U44Qd</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Carp, Howard</creator><creator>Toder, Vladimir</creator><creator>Aviram, Ayala</creator><creator>Daniely, Michal</creator><creator>Mashiach, Shlomo</creator><creator>Barkai, Gad</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Karyotype of the abortus in recurrent miscarriage</title><author>Carp, Howard ; Toder, Vladimir ; Aviram, Ayala ; Daniely, Michal ; Mashiach, Shlomo ; Barkai, Gad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-dc23a32eb2ece3f0fcec425220bb32a22f27d28356442c7fd03015f6286f14203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Abortion</topic><topic>Abortion, Habitual - genetics</topic><topic>Adult</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Chromosome Aberrations</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Fetus</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Israel</topic><topic>karyotype</topic><topic>Karyotyping</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monosomy</topic><topic>Odds Ratio</topic><topic>Polyploidy</topic><topic>Pregnancy</topic><topic>pregnancy loss</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>recurrent miscarriage</topic><topic>Retrospective Studies</topic><topic>Sex Chromosome Aberrations</topic><topic>Translocation, Genetic</topic><topic>Trisomy</topic><topic>X Chromosome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carp, Howard</creatorcontrib><creatorcontrib>Toder, Vladimir</creatorcontrib><creatorcontrib>Aviram, Ayala</creatorcontrib><creatorcontrib>Daniely, Michal</creatorcontrib><creatorcontrib>Mashiach, Shlomo</creatorcontrib><creatorcontrib>Barkai, Gad</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carp, Howard</au><au>Toder, Vladimir</au><au>Aviram, Ayala</au><au>Daniely, Michal</au><au>Mashiach, Shlomo</au><au>Barkai, Gad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Karyotype of the abortus in recurrent miscarriage</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>75</volume><issue>4</issue><spage>678</spage><epage>682</epage><pages>678-682</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective: To assess the chromosomal aberrations in the abortus in recurrent miscarriage and the live birth rate after a euploid or aneuploid miscarriage.
Design: Retrospective analysis.
Setting: Tertiary referral unit in university hospital.
Patient(s): One hundred sixty-seven patients with 3 to 16 miscarriages before 20 weeks.
Intervention(s): Material collected at curettage from 167 abortuses was analyzed by standard G-banding techniques.
Main Outcome Measure(s): The incidence of aberrations and the outcome of the subsequent pregnancy were assessed according to the embryonic karyotype.
Result(s): In this study 125 specimens were successfully karyotyped. Of these, 29% (36 of 125) had chromosome aberrations; 94% of the aberrations were aneuploidy, and 6% were structural. The most prevalent anomalies were chromosome 16, 18, and 21 trisomies, triploidy, and monosomy X. After an aneuploid miscarriage, there was a 68% subsequent live birth rate (13 of 19) compared to the 41% (16 of 39) rate after a euploid abortion.
Conclusion(s): The low (29%) incidence of aberrations indicates that alternative mechanisms may be responsible for the majority of recurrent miscarriages. These figures provide a basis for assessing the efficacy of therapy for recurrent miscarriage. If further studies confirm that patients with karyotypically abnormal fetuses have a good prognosis, an informed decision can be made as to whether further investigations and treatment should be undertaken.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11287018</pmid><doi>10.1016/S0015-0282(00)01801-X</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Abortion Abortion, Habitual - genetics Adult Aneuploidy Biological and medical sciences Chromosome Aberrations Diseases of mother, fetus and pregnancy Female Fetus Gynecology. Andrology. Obstetrics Hospitals, University Humans Infant, Newborn Israel karyotype Karyotyping Medical sciences Middle Aged Monosomy Odds Ratio Polyploidy Pregnancy pregnancy loss Pregnancy Outcome Pregnancy. Fetus. Placenta recurrent miscarriage Retrospective Studies Sex Chromosome Aberrations Translocation, Genetic Trisomy X Chromosome |
| title | Karyotype of the abortus in recurrent miscarriage |
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