Novel lipophilic amidate oxorhenium and oxotechnetium complexes as potential brain agents: synthesis, characterization and biological evaluation

Novel oxorhenium and oxotechnetium complexes based on the tetradentate 1-(2-hydroxybenzamido)-2-(pyridinecarboxamido)benzene, H3L, ligand have been synthesized and characterized herein. Thus, by reacting equimolar quantities of the triply deprotonated ligand L3- with the suitable MO3+ precursor, the...

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Veröffentlicht in:	Journal of biological inorganic chemistry 2001-02, Vol.6 (2), p.159-165
Hauptverfasser:	Papadopoulos, M, Nock, B, Maina, T, Pirmettis, I, Raptopoulou, C, Tasiopoulos, A, Troganis, A, Kabanos, T, Terzis, A, Chiotellis, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Crystallography, X-Ray Drug Stability Glutathione - chemistry Male Mice Organometallic Compounds - chemical synthesis Organometallic Compounds - pharmacokinetics Organotechnetium Compounds - chemical synthesis Organotechnetium Compounds - pharmacokinetics Oxidation-Reduction Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - pharmacokinetics Rhenium - chemistry Tissue Distribution
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