Development of a High Throughput Equilibrium Dialysis Method

The identification of large numbers of biologically active chemical entities during high throughput screening (HTS) necessitates the incorporation of new strategies to identify compounds with drug‐like properties early during the lead prioritization and development processes. One of the major steps...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2001-05, Vol.90 (5), p.580-587
Hauptverfasser:	Kariv, Ilona, Cao, Hong, Oldenburg, Kevin R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antidepressive Agents - pharmacokinetics Antihypertensive Agents - pharmacokinetics binding to plasma proteins Biological and medical sciences Blood Proteins - metabolism Dialysis - methods Drug Evaluation, Preclinical equilibrium dialysis General pharmacology high throughput screening Humans Losartan - pharmacokinetics Male Medical sciences Paroxetine - pharmacokinetics Pharmacology. Drug treatments Propranolol - pharmacokinetics Protein Binding - physiology Ultrafiltration - methods
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