Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia

To assess the involvement of spinal inducible nitric oxide synthase (iNOS) in inflammation and nociception. The time course of iNOS mRNA expression in rat spinal cord and inflamed paw was assessed by means of quantitative real time RT-PCR. In addition, the effects of the iNOS inhibitor L-NIL on infl...

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Veröffentlicht in:	Inflammation research 2001-02, Vol.50 (2), p.83-88
Hauptverfasser:	Gühring, H, Tegeder, I, Lötsch, J, Pahl, A, Werner, U, Reeh, P W, Rehse, K, Brune, K, Geisslinger, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Enzyme Inhibitors - pharmacology Foot Hot Temperature Hyperalgesia - enzymology Hyperalgesia - etiology Inflammation - chemically induced Inflammation - enzymology Kinetics Lysine - analogs & derivatives Lysine - pharmacokinetics Lysine - pharmacology Male Nitric Oxide - physiology Nitric Oxide Donors - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Rats Rats, Sprague-Dawley RNA, Messenger - analysis Spinal Cord - chemistry Sydnones - pharmacology Zymosan - administration & dosage
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