Calcium antagonists in mania: A double-blind study of verapamil
Five of seven acutely manic patients improved significantly when taking verapamil but not placebo in a double-blind crossover study. This finding adds support to two other formal studies of verapamil, several case reports of verapamil in manic patients, and one small study of nifedipine suggesting t...
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| Veröffentlicht in: | Psychiatry research 1986-08, Vol.18 (4), p.309-320 |
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| container_end_page | 320 |
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| container_title | Psychiatry research |
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| creator | Dubovsky, Steven L. Franks, Ronald D. Allen, Stephen Murphy, James |
| description | Five of seven acutely manic patients improved significantly when taking verapamil but not placebo in a double-blind crossover study. This finding adds support to two other formal studies of verapamil, several case reports of verapamil in manic patients, and one small study of nifedipine suggesting that some calcium antagonists may have antimanic properties. Indirect evidence links this antimanic action to correction of a disturbance of intracellular calcium dynamics in affective disorders. However, the effectiveness of calcium antagonist drugs could also be related to some property other than interference with the action of calcium within brain neurons. |
| doi_str_mv | 10.1016/0165-1781(86)90016-8 |
| format | Article |
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This finding adds support to two other formal studies of verapamil, several case reports of verapamil in manic patients, and one small study of nifedipine suggesting that some calcium antagonists may have antimanic properties. Indirect evidence links this antimanic action to correction of a disturbance of intracellular calcium dynamics in affective disorders. However, the effectiveness of calcium antagonist drugs could also be related to some property other than interference with the action of calcium within brain neurons.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/0165-1781(86)90016-8</identifier><identifier>PMID: 3529151</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Bipolar Disorder - drug therapy ; Bipolar Disorder - psychology ; calcium antagonists ; Clinical Trials as Topic ; Double-Blind Method ; Female ; Humans ; intracellular calcium ions ; Male ; mania ; Medical sciences ; Middle Aged ; Miscellaneous ; Neuropharmacology ; Pharmacology. 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This finding adds support to two other formal studies of verapamil, several case reports of verapamil in manic patients, and one small study of nifedipine suggesting that some calcium antagonists may have antimanic properties. Indirect evidence links this antimanic action to correction of a disturbance of intracellular calcium dynamics in affective disorders. However, the effectiveness of calcium antagonist drugs could also be related to some property other than interference with the action of calcium within brain neurons.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - psychology</subject><subject>calcium antagonists</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>intracellular calcium ions</subject><subject>Male</subject><subject>mania</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatric Status Rating Scales</subject><subject>Verapamil</subject><subject>Verapamil - therapeutic use</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gcIeRPSwmtnsR-JBKcUvKHjRc5hNshLZj5rsFvrvTe3So4ckDPPMy-Qh5BzoLVDI78LJYig4XPP8RtBQxvyATIEXSVxAwg7JdI8ckxPvvymlCQgxIROWJQIymJLHBdbKDk2EbY9fXWt97yPbRg22Fu-jeaS7oaxNXNa21ZHvB72JuipaG4crbGx9So4qrL05G98Z-Xx--li8xsv3l7fFfBkrxvM-NiLNMqFS4CVUQgMqkYgcSqzCnQuVUSM08rwAqHjOuBZUYVklRqWsYGXKZuRql7ty3c9gfC8b65Wpa2xNN3hZFDQRjNEApjtQuc57Zyq5crZBt5FA5dab3EqRWymS5_LPm-Rh7GLMH8rG6P3QKCr0L8c-eoV15bBV1u-xQqThP1nAHnaYCS7W1jjplTWtMto6o3qpO_v_Hr9JeIe8</recordid><startdate>19860801</startdate><enddate>19860801</enddate><creator>Dubovsky, Steven L.</creator><creator>Franks, Ronald D.</creator><creator>Allen, Stephen</creator><creator>Murphy, James</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860801</creationdate><title>Calcium antagonists in mania: A double-blind study of verapamil</title><author>Dubovsky, Steven L. ; Franks, Ronald D. ; Allen, Stephen ; Murphy, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-e94559c418b1f9d1ac92961baf96169c50e9da86711f8638d90cabf2ec4373b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Bipolar Disorder - psychology</topic><topic>calcium antagonists</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>intracellular calcium ions</topic><topic>Male</topic><topic>mania</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatric Status Rating Scales</topic><topic>Verapamil</topic><topic>Verapamil - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dubovsky, Steven L.</creatorcontrib><creatorcontrib>Franks, Ronald D.</creatorcontrib><creatorcontrib>Allen, Stephen</creatorcontrib><creatorcontrib>Murphy, James</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dubovsky, Steven L.</au><au>Franks, Ronald D.</au><au>Allen, Stephen</au><au>Murphy, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium antagonists in mania: A double-blind study of verapamil</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1986-08-01</date><risdate>1986</risdate><volume>18</volume><issue>4</issue><spage>309</spage><epage>320</epage><pages>309-320</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Five of seven acutely manic patients improved significantly when taking verapamil but not placebo in a double-blind crossover study. This finding adds support to two other formal studies of verapamil, several case reports of verapamil in manic patients, and one small study of nifedipine suggesting that some calcium antagonists may have antimanic properties. Indirect evidence links this antimanic action to correction of a disturbance of intracellular calcium dynamics in affective disorders. However, the effectiveness of calcium antagonist drugs could also be related to some property other than interference with the action of calcium within brain neurons.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>3529151</pmid><doi>10.1016/0165-1781(86)90016-8</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-1781 |
| ispartof | Psychiatry research, 1986-08, Vol.18 (4), p.309-320 |
| issn | 0165-1781 1872-7123 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Biological and medical sciences Bipolar Disorder - drug therapy Bipolar Disorder - psychology calcium antagonists Clinical Trials as Topic Double-Blind Method Female Humans intracellular calcium ions Male mania Medical sciences Middle Aged Miscellaneous Neuropharmacology Pharmacology. Drug treatments Psychiatric Status Rating Scales Verapamil Verapamil - therapeutic use |
| title | Calcium antagonists in mania: A double-blind study of verapamil |
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