Anti-tumor activities of chondroitinase AC and chondroitinase B: inhibition of angiogenesis, proliferation and invasion

In the current study, two specific glycosaminoglycan lyases, chondroitinase AC and chondroitinase B, were utilized to examine the roles of chondroitin sulfates and dermatan sulfate in tumor metastasis and angiogenesis. Melanoma cells (SK-MEL) or endothelial cells were treated with either medium or c...

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Veröffentlicht in:	European journal of pharmacology 2001-03, Vol.416 (3), p.213-221
Hauptverfasser:	Denholm, Elizabeth M., Lin, Yong-Qing, Silver, Paul J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Antineoplastic agents Apoptosis Apoptosis - drug effects Biological and medical sciences Cattle Cell Division - drug effects Cell Movement - drug effects Cells, Cultured Chemotherapy Chondroitin sulfate Chondroitin Sulfates - physiology Chondroitinase Chondroitinases and Chondroitin Lyases - pharmacology Dermatan Dermatan Sulfate - physiology Dose-Response Relationship, Drug Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Experimental cardiovascular tumors Gelatinases - metabolism Humans Medical sciences Melanoma - pathology Metastasis Neoplasm Metastasis Neovascularization, Pathologic Neovascularization, Physiologic - drug effects Pharmacology. Drug treatments Proliferation Tumor Cells, Cultured Tumors
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