Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus
Cytokines are important mediators of immune regulation and have been implicated in the pathogenesis of the neurological disturbances, which occur in up to sixty percent of patients with systemic lupus erythematosus (SLE). SLE is an autoimmune disease characterized by the presence of autoantibodies a...
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| Veröffentlicht in: | Neuroscience letters 2001-04, Vol.302 (2), p.129-132 |
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| creator | Tomita, Michiyo Holman, Brita J. Santoro, Thomas J. |
| description | Cytokines are important mediators of immune regulation and have been implicated in the pathogenesis of the neurological disturbances, which occur in up to sixty percent of patients with systemic lupus erythematosus (SLE). SLE is an autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, including native DNA. Cytokines are thought to drive autoantibody production in lupus. Certain of the derangements in memory and learning described in human and experimental SLE map to the hippocampus. The current study examines the expression of cytokine genes in the hippocampus in lupus, using MRL-
lpr/lpr mice as the experimental model. These mice spontaneously develop a SLE-like illness accompanied by disturbances in spatial learning. Our results suggest a potential role for proinflammatory cytokines in the cognitive aberrations observed in lupus. |
| doi_str_mv | 10.1016/S0304-3940(01)01679-2 |
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lpr/lpr mice as the experimental model. These mice spontaneously develop a SLE-like illness accompanied by disturbances in spatial learning. Our results suggest a potential role for proinflammatory cytokines in the cognitive aberrations observed in lupus.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(01)01679-2</identifier><identifier>PMID: 11290404</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cell Differentiation - immunology ; Cytokines ; Cytokines - immunology ; Cytokines - metabolism ; DNA, Complementary - immunology ; Gene expression ; Gene Expression Regulation - immunology ; Hippocampus ; Hippocampus - immunology ; Hippocampus - metabolism ; Hippocampus - physiopathology ; Learning Disorders - immunology ; Learning Disorders - metabolism ; Learning Disorders - physiopathology ; Lupus Erythematosus, Systemic - immunology ; Lupus Erythematosus, Systemic - metabolism ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Mutant Strains ; MRL- lpr/lpr mice ; Neuronal Plasticity - immunology ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Systemic lupus erythematosus</subject><ispartof>Neuroscience letters, 2001-04, Vol.302 (2), p.129-132</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-5cb81e26d8f17a1d987bfe5266b8049e7a553341725c82fe2c26f751b6d1a7173</citedby><cites>FETCH-LOGICAL-c420t-5cb81e26d8f17a1d987bfe5266b8049e7a553341725c82fe2c26f751b6d1a7173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394001016792$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=936276$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11290404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tomita, Michiyo</creatorcontrib><creatorcontrib>Holman, Brita J.</creatorcontrib><creatorcontrib>Santoro, Thomas J.</creatorcontrib><title>Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Cytokines are important mediators of immune regulation and have been implicated in the pathogenesis of the neurological disturbances, which occur in up to sixty percent of patients with systemic lupus erythematosus (SLE). SLE is an autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, including native DNA. Cytokines are thought to drive autoantibody production in lupus. Certain of the derangements in memory and learning described in human and experimental SLE map to the hippocampus. The current study examines the expression of cytokine genes in the hippocampus in lupus, using MRL-
lpr/lpr mice as the experimental model. These mice spontaneously develop a SLE-like illness accompanied by disturbances in spatial learning. Our results suggest a potential role for proinflammatory cytokines in the cognitive aberrations observed in lupus.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - immunology</subject><subject>Cytokines</subject><subject>Cytokines - immunology</subject><subject>Cytokines - metabolism</subject><subject>DNA, Complementary - immunology</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - immunology</subject><subject>Hippocampus</subject><subject>Hippocampus - immunology</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - physiopathology</subject><subject>Learning Disorders - immunology</subject><subject>Learning Disorders - metabolism</subject><subject>Learning Disorders - physiopathology</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lupus Erythematosus, Systemic - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Mice, Mutant Strains</subject><subject>MRL- lpr/lpr mice</subject><subject>Neuronal Plasticity - immunology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Systemic lupus erythematosus</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpaTZpf0KDoVCSg9sZ2bLsUwmhSQqBHtqeehCyPG6U-Csau3T_feXdJT0GwQjeeWYkHiHeIXxEwOLTd8ggT7MqhzPA85joKpUvxAZLLVNdaflSbJ6QI3HMfA8AClX-WhwhygpyyDfi10VNIdhhTtx2Hh_8QMlvioX-ToGY_TgkfkjmO0ru_DSNzvbTwmvUL2GFecsz9d4l3bI2KGwj29t55IXfiFet7ZjeHu4T8fPqy4_Lm_T22_XXy4vb1OUS5lS5ukSSRVO2qC02VanrlpQsirqEvCJtlcqyHLVUrpQtSSeLViusiwatRp2diA_7vVMYHxfi2fSeHXWdHWhc2GgNssQMnwWxhHh2oNqDLozMgVozBd_bsDUIZtVvdvrN6tYAmp1-I-Pc6eGBpe6p-T918B2B9wfAsrNdG807z09clRVSF5H6vKcoWvvjKRh2ngZHjQ_kZtOM_pmP_ANDcaGk</recordid><startdate>20010420</startdate><enddate>20010420</enddate><creator>Tomita, Michiyo</creator><creator>Holman, Brita J.</creator><creator>Santoro, Thomas J.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20010420</creationdate><title>Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus</title><author>Tomita, Michiyo ; Holman, Brita J. ; Santoro, Thomas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-5cb81e26d8f17a1d987bfe5266b8049e7a553341725c82fe2c26f751b6d1a7173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - immunology</topic><topic>Cytokines</topic><topic>Cytokines - immunology</topic><topic>Cytokines - metabolism</topic><topic>DNA, Complementary - immunology</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - immunology</topic><topic>Hippocampus</topic><topic>Hippocampus - immunology</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - physiopathology</topic><topic>Learning Disorders - immunology</topic><topic>Learning Disorders - metabolism</topic><topic>Learning Disorders - physiopathology</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Lupus Erythematosus, Systemic - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><topic>Mice, Mutant Strains</topic><topic>MRL- lpr/lpr mice</topic><topic>Neuronal Plasticity - immunology</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tomita, Michiyo</creatorcontrib><creatorcontrib>Holman, Brita J.</creatorcontrib><creatorcontrib>Santoro, Thomas J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tomita, Michiyo</au><au>Holman, Brita J.</au><au>Santoro, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2001-04-20</date><risdate>2001</risdate><volume>302</volume><issue>2</issue><spage>129</spage><epage>132</epage><pages>129-132</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Cytokines are important mediators of immune regulation and have been implicated in the pathogenesis of the neurological disturbances, which occur in up to sixty percent of patients with systemic lupus erythematosus (SLE). SLE is an autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, including native DNA. Cytokines are thought to drive autoantibody production in lupus. Certain of the derangements in memory and learning described in human and experimental SLE map to the hippocampus. The current study examines the expression of cytokine genes in the hippocampus in lupus, using MRL-
lpr/lpr mice as the experimental model. These mice spontaneously develop a SLE-like illness accompanied by disturbances in spatial learning. Our results suggest a potential role for proinflammatory cytokines in the cognitive aberrations observed in lupus.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11290404</pmid><doi>10.1016/S0304-3940(01)01679-2</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cell Differentiation - immunology Cytokines Cytokines - immunology Cytokines - metabolism DNA, Complementary - immunology Gene expression Gene Expression Regulation - immunology Hippocampus Hippocampus - immunology Hippocampus - metabolism Hippocampus - physiopathology Learning Disorders - immunology Learning Disorders - metabolism Learning Disorders - physiopathology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Medical sciences Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Mutant Strains MRL- lpr/lpr mice Neuronal Plasticity - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Systemic lupus erythematosus |
| title | Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus |
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