Release of biologically active TGF-beta from airway smooth muscle cells induces autocrine synthesis of collagen

In severe or chronic asthma, there is an increase in airway smooth muscle cell (ASMC) mass as well as an increase in connective tissue proteins in the smooth muscle layer of airways. Transforming growth factor-beta (TGF-beta) exists in three isoforms in mammals and is a potent regulator of connectiv...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2001-05, Vol.280 (5), p.L999-L1008
Hauptverfasser:	Coutts, A, Chen, G, Stephens, N, Hirst, S, Douglas, D, Eichholtz, T, Khalil, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aprotinin - pharmacology Asthma - complications Asthma - metabolism Autocrine Communication - physiology Biological Assay Carrier Proteins - metabolism Cattle Cells, Cultured Collagen - biosynthesis Extracellular Space - metabolism Fibrinolysin - antagonists & inhibitors Fibrinolysin - metabolism Fibrinolysin - pharmacology Fibrosis - etiology Intracellular Signaling Peptides and Proteins Latent TGF-beta Binding Proteins Mink Muscle, Smooth - cytology Muscle, Smooth - drug effects Muscle, Smooth - metabolism Procollagen - biosynthesis Serine Proteinase Inhibitors - pharmacology Trachea Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - secretion
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