Mechanism of specific nuclear transport of adriamycin : The mode of nuclear translocation of adriamycin-proteasome complex

Adriamycin (ADM), an anthracycline anticancer agent, is selectively stored in the nuclei of a variety of proliferating cells, but the precise mechanism of specific nuclear transport of ADM is not well known. Recently, we demonstrated that ADM shows high binding affinity to the cytoplasmic proteasome...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2001-03, Vol.61 (6), p.2467-2471
Hauptverfasser:	KIYOMIYA, Ken-Ichi, MATSUO, Saburou, KUREBE, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - physiology Adenosine Triphosphate - metabolism Affinity Labels - chemistry Animals Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - metabolism Antineoplastic agents Biological and medical sciences Cell Membrane Permeability - drug effects Cell Nucleus - metabolism Chemotherapy Cysteine Endopeptidases - chemistry Cysteine Endopeptidases - isolation & purification Cysteine Endopeptidases - metabolism Digitonin - pharmacology Doxorubicin - chemistry Doxorubicin - metabolism Electrophoresis, Polyacrylamide Gel Leukemia L1210 - metabolism Medical sciences Melanoma, Experimental - metabolism Mice Microscopy, Confocal Multienzyme Complexes - chemistry Multienzyme Complexes - isolation & purification Multienzyme Complexes - metabolism Pharmacology. Drug treatments Proteasome Endopeptidase Complex
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