Adenoviral Gene Transfer Restores Lysyl Hydroxylase Activity in Type VI Ehlers-Danlos Syndrome

Type VI Ehlers-Danlos syndrome is a disease characterized by disturbed lysine hydroxylation of collagen. The disease is caused by mutations in lysyl hydroxylase 1 gene and it affects several organs including the cardiovascular system, the joint and musculoskeletal system, and the skin. The skin of t...

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Veröffentlicht in:	Journal of investigative dermatology 2001-04, Vol.116 (4), p.602-605
Hauptverfasser:	Rauma, Tanja, Kumpumäki, Sanna, Anderson, Richard, Davidson, Beverly L., Ruotsalainen, Heli, Myllylä, Raili, Hautala, Timo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Biological and medical sciences collagen connective tissue Ehlers-Danlos Syndrome - classification Ehlers-Danlos Syndrome - enzymology Ehlers-Danlos Syndrome - pathology Fibroblasts - enzymology Galactosidases - genetics Gene Transfer Techniques Humans Hydroxylysine - metabolism inherited disease Medical sciences Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - genetics Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - metabolism RNA, Messenger - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin - enzymology Skin - metabolism Skin - pathology Skin - physiopathology
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