Invasion activating caveolin-1 mutation in human scirrhous breast cancers
We looked for mutations in the caveolin-1 gene, encoding a critical molecule for membrane signaling to cell growth, in 92 primary human breast cancers, and we report here the identification of a mutation in caveolin-1 at codon 132 (P132L) in 16% of cases. The mutation-positive cases were mostly inva...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2001-03, Vol.61 (6), p.2361-2364 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | HAYASHI, Kazuhiko MATSUDA, Satoru MACHIDA, Kazuya YAMAMOTO, Tatsuyoshi FUKUDA, Yoshihide NIMURA, Yuji HAYAKAWA, Tetsuo HAMAGUCHI, Michinari |
| description | We looked for mutations in the caveolin-1 gene, encoding a critical molecule for membrane signaling to cell growth, in 92 primary human breast cancers, and we report here the identification of a mutation in caveolin-1 at codon 132 (P132L) in 16% of cases. The mutation-positive cases were mostly invasive scirrhous carcinomas. In cell lines expressing the same mutant of caveolin-1, we observed that the mutant Caveolin-1 expression seemed to induce cellular transformation and activation of mitogen-activated protein kinase-signaling pathway and to promote invasion-ability as well as altered actin networks in the cells. These results provide, for the first time, genetic evidence that a functioning Caveolin-1 mutation may have a role in the malignant progression of human breast cancer. |
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The mutation-positive cases were mostly invasive scirrhous carcinomas. In cell lines expressing the same mutant of caveolin-1, we observed that the mutant Caveolin-1 expression seemed to induce cellular transformation and activation of mitogen-activated protein kinase-signaling pathway and to promote invasion-ability as well as altered actin networks in the cells. These results provide, for the first time, genetic evidence that a functioning Caveolin-1 mutation may have a role in the malignant progression of human breast cancer.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 11289096</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>3T3 Cells ; Adenocarcinoma, Scirrhous - genetics ; Adenocarcinoma, Scirrhous - pathology ; Amino Acid Sequence ; Animals ; Biological and medical sciences ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Caveolin 1 ; Caveolins - genetics ; Cell Transformation, Neoplastic - genetics ; Codon ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; MAP Kinase Signaling System - genetics ; Medical sciences ; Mice ; Molecular Sequence Data ; Mutation ; Neoplasm Invasiveness ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Sequence Homology, Amino Acid ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 2001-03, Vol.61 (6), p.2361-2364</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=927947$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11289096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAYASHI, Kazuhiko</creatorcontrib><creatorcontrib>MATSUDA, Satoru</creatorcontrib><creatorcontrib>MACHIDA, Kazuya</creatorcontrib><creatorcontrib>YAMAMOTO, Tatsuyoshi</creatorcontrib><creatorcontrib>FUKUDA, Yoshihide</creatorcontrib><creatorcontrib>NIMURA, Yuji</creatorcontrib><creatorcontrib>HAYAKAWA, Tetsuo</creatorcontrib><creatorcontrib>HAMAGUCHI, Michinari</creatorcontrib><title>Invasion activating caveolin-1 mutation in human scirrhous breast cancers</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>We looked for mutations in the caveolin-1 gene, encoding a critical molecule for membrane signaling to cell growth, in 92 primary human breast cancers, and we report here the identification of a mutation in caveolin-1 at codon 132 (P132L) in 16% of cases. The mutation-positive cases were mostly invasive scirrhous carcinomas. In cell lines expressing the same mutant of caveolin-1, we observed that the mutant Caveolin-1 expression seemed to induce cellular transformation and activation of mitogen-activated protein kinase-signaling pathway and to promote invasion-ability as well as altered actin networks in the cells. These results provide, for the first time, genetic evidence that a functioning Caveolin-1 mutation may have a role in the malignant progression of human breast cancer.</description><subject>3T3 Cells</subject><subject>Adenocarcinoma, Scirrhous - genetics</subject><subject>Adenocarcinoma, Scirrhous - pathology</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Caveolin 1</subject><subject>Caveolins - genetics</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Codon</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>MAP Kinase Signaling System - genetics</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Neoplasm Invasiveness</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Sequence Homology, Amino Acid</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j1tLxDAQhYMo7rr6F6Qg-FZI2sntURYvCwu-6HOZZFMbadM1aRf89wasPg0z853DOWdkzXitSgnAz8maUqpKDrJakauUPvPKGeWXZMVYpTTVYk12u3DC5MdQoJ38CScfPgqLJzf2PpSsGOYp3_Lbh6KbBwxFsj7GbpxTYaLDNGU6WBfTNblosU_uZpkb8v70-LZ9Kfevz7vtw77sKqGm0oJhYIAzC62kRmtFHXdMWMppbZBLnqNZR1EBUwBOHATPCs5Q6NZUqt6Q-1_fYxy_ZpemZvDJur7H4HKqRkpagQSRwdsFnM3gDs0x-gHjd_NXPgN3C4DJYt_GXMSnf05XUoOsfwDlc2Kx</recordid><startdate>20010315</startdate><enddate>20010315</enddate><creator>HAYASHI, Kazuhiko</creator><creator>MATSUDA, Satoru</creator><creator>MACHIDA, Kazuya</creator><creator>YAMAMOTO, Tatsuyoshi</creator><creator>FUKUDA, Yoshihide</creator><creator>NIMURA, Yuji</creator><creator>HAYAKAWA, Tetsuo</creator><creator>HAMAGUCHI, Michinari</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20010315</creationdate><title>Invasion activating caveolin-1 mutation in human scirrhous breast cancers</title><author>HAYASHI, Kazuhiko ; MATSUDA, Satoru ; MACHIDA, Kazuya ; YAMAMOTO, Tatsuyoshi ; FUKUDA, Yoshihide ; NIMURA, Yuji ; HAYAKAWA, Tetsuo ; HAMAGUCHI, Michinari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h268t-c4b14b451c4f70b9980e5e16c0503ba575289ce0a841844e6d65b1451a69fb283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>3T3 Cells</topic><topic>Adenocarcinoma, Scirrhous - genetics</topic><topic>Adenocarcinoma, Scirrhous - pathology</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Caveolin 1</topic><topic>Caveolins - genetics</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Codon</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>MAP Kinase Signaling System - genetics</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Neoplasm Invasiveness</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Sequence Homology, Amino Acid</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAYASHI, Kazuhiko</creatorcontrib><creatorcontrib>MATSUDA, Satoru</creatorcontrib><creatorcontrib>MACHIDA, Kazuya</creatorcontrib><creatorcontrib>YAMAMOTO, Tatsuyoshi</creatorcontrib><creatorcontrib>FUKUDA, Yoshihide</creatorcontrib><creatorcontrib>NIMURA, Yuji</creatorcontrib><creatorcontrib>HAYAKAWA, Tetsuo</creatorcontrib><creatorcontrib>HAMAGUCHI, Michinari</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAYASHI, Kazuhiko</au><au>MATSUDA, Satoru</au><au>MACHIDA, Kazuya</au><au>YAMAMOTO, Tatsuyoshi</au><au>FUKUDA, Yoshihide</au><au>NIMURA, Yuji</au><au>HAYAKAWA, Tetsuo</au><au>HAMAGUCHI, Michinari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Invasion activating caveolin-1 mutation in human scirrhous breast cancers</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>2001-03-15</date><risdate>2001</risdate><volume>61</volume><issue>6</issue><spage>2361</spage><epage>2364</epage><pages>2361-2364</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>We looked for mutations in the caveolin-1 gene, encoding a critical molecule for membrane signaling to cell growth, in 92 primary human breast cancers, and we report here the identification of a mutation in caveolin-1 at codon 132 (P132L) in 16% of cases. The mutation-positive cases were mostly invasive scirrhous carcinomas. In cell lines expressing the same mutant of caveolin-1, we observed that the mutant Caveolin-1 expression seemed to induce cellular transformation and activation of mitogen-activated protein kinase-signaling pathway and to promote invasion-ability as well as altered actin networks in the cells. These results provide, for the first time, genetic evidence that a functioning Caveolin-1 mutation may have a role in the malignant progression of human breast cancer.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>11289096</pmid><tpages>4</tpages></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | 3T3 Cells Adenocarcinoma, Scirrhous - genetics Adenocarcinoma, Scirrhous - pathology Amino Acid Sequence Animals Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - pathology Caveolin 1 Caveolins - genetics Cell Transformation, Neoplastic - genetics Codon Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases MAP Kinase Signaling System - genetics Medical sciences Mice Molecular Sequence Data Mutation Neoplasm Invasiveness Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Sequence Homology, Amino Acid Tumors |
| title | Invasion activating caveolin-1 mutation in human scirrhous breast cancers |
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