Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. The actin–myosin system has been proposed to be the source of contractile force that drives bleb formation, although the biochemical pathway that promotes actin–myos...

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Veröffentlicht in:	Nature cell biology 2001-04, Vol.3 (4), p.339-345
Hauptverfasser:	Coleman, Mathew L., Sahai, Erik A., Yeo, Margaret, Bosch, Marta, Dewar, Ann, Olson, Michael F.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Apoptosis Biomedical and Life Sciences Cancer Research Caspase Inhibitors Caspases - metabolism Cell Biology Cell Membrane - pathology Cell morphology Deoxyribonucleic acid Developmental Biology DNA DNA - metabolism DNA Fragmentation Enzyme Activation Fibroblasts Humans Intracellular Signaling Peptides and Proteins Kinases Life Sciences Membranes Mice Morphology Phosphorylation Physiological aspects Protein kinases Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Recombinant Fusion Proteins - genetics rho-Associated Kinases Rocks Stem Cells Tumor Cells, Cultured
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