Comparison of Amniotic Fluid Disaturated Phosphatidylcholine and the Lecithin- Sphingomyelin Ratio in the Prediction of Fetal Lung Maturity
Although use of the lecithin-sphingomyelin (L/S) ratio has contributed to a reduction in the frequency of respiratory distress syndrome (RDS), its accuracy in pregnancies complicated by fetomaternal disease has been questioned. Disaturated phosphatidylcholine is the major active component of surfact...
Gespeichert in:
| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1986-10, Vol.68 (4), p.541-545 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 545 |
|---|---|
| container_issue | 4 |
| container_start_page | 541 |
| container_title | Obstetrics and gynecology (New York. 1953) |
| container_volume | 68 |
| creator | NUGENT, CLARK E AYERS, JONATHAN W. T MENON, K M J |
| description | Although use of the lecithin-sphingomyelin (L/S) ratio has contributed to a reduction in the frequency of respiratory distress syndrome (RDS), its accuracy in pregnancies complicated by fetomaternal disease has been questioned. Disaturated phosphatidylcholine is the major active component of surfactant and has been advocated as being a more specific indicator of fetal lung maturity. A study of 105 pregnancies in which a L/S ratio and disaturated phosphatidylcholine assay were performed on amniotic fluid was carried out to ascertain if amniotic fluid disaturated phosphatidylcholine is indeed a more accurate predictor of RDS. The results of this investigation reveal no significant difference in the reliability of these two tests in predicting neonatal RDS. Five infants developed RDS with a mature L/S ratio ranging from 2.0 to 3.36, suggesting that the disaturated phosphatidylcholine assay may be a helpful adjunctive test in instances in which the L/S ratio is less than 3.5. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_77023029</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77023029</sourcerecordid><originalsourceid>FETCH-LOGICAL-p2802-76526125ab550b1b6eb4d8d3cef8376ba0ad1bafbfe0f9da753814ef2731426f3</originalsourceid><addsrcrecordid>eNo9kc1q3DAQx01JSLZJHqGgQ8nNoA_L8h7DNpsUtjQ0LfRmxtYoVitbjiQT9hn60tEmSw_Dfz5-zAwzH4oVa5QouRC_T4oVpXxdqqaqzouPMf6hlLJ6Lc6KM6GqRlK5Kv5t_DhDsNFPxBtyM07WJ9uTrVusJl9shLQESKjJw-DjPECyeu_6wTs7IYFJkzQg2WFv02CnkjzOWZ78uMcMkB8Z9yQ7B-ghoLZ9TrxN2mICR3bL9ES-HWbYtL8sTg24iFdHvSh-bW9_bu7L3fe7r5ubXTnzhvJS1ZLXjEvopKQd62rsKt1o0aNphKo7oKBZB6YzSM1ag5KiYRUargSreG3ERXH93ncO_nnBmNrRxh6dgwn9ElulKBf5chn8dASXbkTdzsGOEPbt8Xq5_vlYh9iDMwGm3sb_WF5WMMkyVr1jL94lDPGvW14wtAOCS0Obn0JrLmnJ1k3NDlGZjXPxCrG_iz8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77023029</pqid></control><display><type>article</type><title>Comparison of Amniotic Fluid Disaturated Phosphatidylcholine and the Lecithin- Sphingomyelin Ratio in the Prediction of Fetal Lung Maturity</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>NUGENT, CLARK E ; AYERS, JONATHAN W. T ; MENON, K M J</creator><creatorcontrib>NUGENT, CLARK E ; AYERS, JONATHAN W. T ; MENON, K M J</creatorcontrib><description>Although use of the lecithin-sphingomyelin (L/S) ratio has contributed to a reduction in the frequency of respiratory distress syndrome (RDS), its accuracy in pregnancies complicated by fetomaternal disease has been questioned. Disaturated phosphatidylcholine is the major active component of surfactant and has been advocated as being a more specific indicator of fetal lung maturity. A study of 105 pregnancies in which a L/S ratio and disaturated phosphatidylcholine assay were performed on amniotic fluid was carried out to ascertain if amniotic fluid disaturated phosphatidylcholine is indeed a more accurate predictor of RDS. The results of this investigation reveal no significant difference in the reliability of these two tests in predicting neonatal RDS. Five infants developed RDS with a mature L/S ratio ranging from 2.0 to 3.36, suggesting that the disaturated phosphatidylcholine assay may be a helpful adjunctive test in instances in which the L/S ratio is less than 3.5.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 3748505</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Amniotic Fluid - analysis ; Biological and medical sciences ; Fetal Organ Maturity ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Lung - embryology ; Management. Prenatal diagnosis ; Medical sciences ; Phosphatidylcholines - analysis ; Pregnancy. Fetus. Placenta ; Prognosis ; Respiratory Distress Syndrome, Newborn - diagnosis ; Sphingomyelins - analysis</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1986-10, Vol.68 (4), p.541-545</ispartof><rights>1986 The American College of Obstetricians and Gynecologists</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8023151$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3748505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NUGENT, CLARK E</creatorcontrib><creatorcontrib>AYERS, JONATHAN W. T</creatorcontrib><creatorcontrib>MENON, K M J</creatorcontrib><title>Comparison of Amniotic Fluid Disaturated Phosphatidylcholine and the Lecithin- Sphingomyelin Ratio in the Prediction of Fetal Lung Maturity</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Although use of the lecithin-sphingomyelin (L/S) ratio has contributed to a reduction in the frequency of respiratory distress syndrome (RDS), its accuracy in pregnancies complicated by fetomaternal disease has been questioned. Disaturated phosphatidylcholine is the major active component of surfactant and has been advocated as being a more specific indicator of fetal lung maturity. A study of 105 pregnancies in which a L/S ratio and disaturated phosphatidylcholine assay were performed on amniotic fluid was carried out to ascertain if amniotic fluid disaturated phosphatidylcholine is indeed a more accurate predictor of RDS. The results of this investigation reveal no significant difference in the reliability of these two tests in predicting neonatal RDS. Five infants developed RDS with a mature L/S ratio ranging from 2.0 to 3.36, suggesting that the disaturated phosphatidylcholine assay may be a helpful adjunctive test in instances in which the L/S ratio is less than 3.5.</description><subject>Amniotic Fluid - analysis</subject><subject>Biological and medical sciences</subject><subject>Fetal Organ Maturity</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Lung - embryology</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Phosphatidylcholines - analysis</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prognosis</subject><subject>Respiratory Distress Syndrome, Newborn - diagnosis</subject><subject>Sphingomyelins - analysis</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1q3DAQx01JSLZJHqGgQ8nNoA_L8h7DNpsUtjQ0LfRmxtYoVitbjiQT9hn60tEmSw_Dfz5-zAwzH4oVa5QouRC_T4oVpXxdqqaqzouPMf6hlLJ6Lc6KM6GqRlK5Kv5t_DhDsNFPxBtyM07WJ9uTrVusJl9shLQESKjJw-DjPECyeu_6wTs7IYFJkzQg2WFv02CnkjzOWZ78uMcMkB8Z9yQ7B-ghoLZ9TrxN2mICR3bL9ES-HWbYtL8sTg24iFdHvSh-bW9_bu7L3fe7r5ubXTnzhvJS1ZLXjEvopKQd62rsKt1o0aNphKo7oKBZB6YzSM1ag5KiYRUargSreG3ERXH93ncO_nnBmNrRxh6dgwn9ElulKBf5chn8dASXbkTdzsGOEPbt8Xq5_vlYh9iDMwGm3sb_WF5WMMkyVr1jL94lDPGvW14wtAOCS0Obn0JrLmnJ1k3NDlGZjXPxCrG_iz8</recordid><startdate>198610</startdate><enddate>198610</enddate><creator>NUGENT, CLARK E</creator><creator>AYERS, JONATHAN W. T</creator><creator>MENON, K M J</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198610</creationdate><title>Comparison of Amniotic Fluid Disaturated Phosphatidylcholine and the Lecithin- Sphingomyelin Ratio in the Prediction of Fetal Lung Maturity</title><author>NUGENT, CLARK E ; AYERS, JONATHAN W. T ; MENON, K M J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2802-76526125ab550b1b6eb4d8d3cef8376ba0ad1bafbfe0f9da753814ef2731426f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Amniotic Fluid - analysis</topic><topic>Biological and medical sciences</topic><topic>Fetal Organ Maturity</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Lung - embryology</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Phosphatidylcholines - analysis</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prognosis</topic><topic>Respiratory Distress Syndrome, Newborn - diagnosis</topic><topic>Sphingomyelins - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NUGENT, CLARK E</creatorcontrib><creatorcontrib>AYERS, JONATHAN W. T</creatorcontrib><creatorcontrib>MENON, K M J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NUGENT, CLARK E</au><au>AYERS, JONATHAN W. T</au><au>MENON, K M J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Amniotic Fluid Disaturated Phosphatidylcholine and the Lecithin- Sphingomyelin Ratio in the Prediction of Fetal Lung Maturity</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1986-10</date><risdate>1986</risdate><volume>68</volume><issue>4</issue><spage>541</spage><epage>545</epage><pages>541-545</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Although use of the lecithin-sphingomyelin (L/S) ratio has contributed to a reduction in the frequency of respiratory distress syndrome (RDS), its accuracy in pregnancies complicated by fetomaternal disease has been questioned. Disaturated phosphatidylcholine is the major active component of surfactant and has been advocated as being a more specific indicator of fetal lung maturity. A study of 105 pregnancies in which a L/S ratio and disaturated phosphatidylcholine assay were performed on amniotic fluid was carried out to ascertain if amniotic fluid disaturated phosphatidylcholine is indeed a more accurate predictor of RDS. The results of this investigation reveal no significant difference in the reliability of these two tests in predicting neonatal RDS. Five infants developed RDS with a mature L/S ratio ranging from 2.0 to 3.36, suggesting that the disaturated phosphatidylcholine assay may be a helpful adjunctive test in instances in which the L/S ratio is less than 3.5.</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>3748505</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 1986-10, Vol.68 (4), p.541-545 |
| issn | 0029-7844 1873-233X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77023029 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Amniotic Fluid - analysis Biological and medical sciences Fetal Organ Maturity Gynecology. Andrology. Obstetrics Humans Infant, Newborn Lung - embryology Management. Prenatal diagnosis Medical sciences Phosphatidylcholines - analysis Pregnancy. Fetus. Placenta Prognosis Respiratory Distress Syndrome, Newborn - diagnosis Sphingomyelins - analysis |
| title | Comparison of Amniotic Fluid Disaturated Phosphatidylcholine and the Lecithin- Sphingomyelin Ratio in the Prediction of Fetal Lung Maturity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-02T10%3A54%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20Amniotic%20Fluid%20Disaturated%20Phosphatidylcholine%20and%20the%20Lecithin-%20Sphingomyelin%20Ratio%20in%20the%20Prediction%20of%20Fetal%20Lung%20Maturity&rft.jtitle=Obstetrics%20and%20gynecology%20(New%20York.%201953)&rft.au=NUGENT,%20CLARK%20E&rft.date=1986-10&rft.volume=68&rft.issue=4&rft.spage=541&rft.epage=545&rft.pages=541-545&rft.issn=0029-7844&rft.eissn=1873-233X&rft.coden=OBGNAS&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E77023029%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77023029&rft_id=info:pmid/3748505&rfr_iscdi=true |