Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells: involvement of Cdc2, p21(waf/cip1), p27(kip1), and Cdc25C expression

Genistein, a soy isoflavone, has been reported to inhibit the multiplication of numerous neoplastic cells, including those in the breast. However, there is limited information on the effect of genistein on nonneoplastic human breast cells. In the present studies, genistein inhibited proliferation of...

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Veröffentlicht in:	Biochemical pharmacology 2001-04, Vol.61 (8), p.979-989
Hauptverfasser:	Frey, R S, Li, J, Singletary, K W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology CDC2 Protein Kinase - biosynthesis CDC2 Protein Kinase - physiology cdc25 Phosphatases - biosynthesis cdc25 Phosphatases - physiology Cell Cycle - drug effects Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - physiology Cell Division - drug effects Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclins - biosynthesis Cyclins - physiology Down-Regulation - drug effects Epithelial Cells - drug effects Epithelial Cells - pathology Gene Expression Regulation - drug effects Genistein - pharmacology Humans Mammary Neoplasms, Animal - pathology Microtubule-Associated Proteins - biosynthesis Microtubule-Associated Proteins - physiology Phosphorylation - drug effects Protein Kinases - metabolism Tumor Cells, Cultured Tumor Suppressor Proteins Up-Regulation - drug effects
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