How antidepressants work: New perspectives on the pathophysiology of depressive disorder
New research in animals is beginning to change radically our understanding of the biology of stress and the effects of antidepressant agents. To relate recent findings from the basic neurosciences to the pathophysiology of depressive disorder. Drawing together findings from molecular and physiologic...
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| Veröffentlicht in: | British journal of psychiatry 2001-04, Vol.178 (4), p.299-303 |
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| container_title | British journal of psychiatry |
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| creator | REID, IAN C STEWART, CAROLINE A |
| description | New research in animals is beginning to change radically our understanding of the biology of stress and the effects of antidepressant agents.
To relate recent findings from the basic neurosciences to the pathophysiology of depressive disorder.
Drawing together findings from molecular and physiological studies in rats, social studies in primates and neuropsychological studies in humans, we review the neurotrophic and neuroplastic effects of antidepressants and stress.
Stress and antidepressants have reciprocal actions on neuronal growth and vulnerability (mediated by the expression of neurotrophins) and synaptic plasticity (mediated by excitatory amino acid neurotransmission) in the hippocampus and other brain structures. Stressors have the capacity to progressively disrupt both the activities of individual cells and the operating characteristics of networks of neurons throughout the life cycle, while antidepressant treatments act to reverse such injurious effects.
We propose a central role for the regulation of synaptic connectivity in the pathophysiology of depressive disorder. |
| doi_str_mv | 10.1192/bjp.178.4.299 |
| format | Article |
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To relate recent findings from the basic neurosciences to the pathophysiology of depressive disorder.
Drawing together findings from molecular and physiological studies in rats, social studies in primates and neuropsychological studies in humans, we review the neurotrophic and neuroplastic effects of antidepressants and stress.
Stress and antidepressants have reciprocal actions on neuronal growth and vulnerability (mediated by the expression of neurotrophins) and synaptic plasticity (mediated by excitatory amino acid neurotransmission) in the hippocampus and other brain structures. Stressors have the capacity to progressively disrupt both the activities of individual cells and the operating characteristics of networks of neurons throughout the life cycle, while antidepressant treatments act to reverse such injurious effects.
We propose a central role for the regulation of synaptic connectivity in the pathophysiology of depressive disorder.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.178.4.299</identifier><identifier>PMID: 11282807</identifier><language>eng</language><publisher>England: RCP</publisher><subject>Alzheimer's disease ; Amino acids ; Animal cognition ; Animals ; Antidepressants ; Antidepressive Agents - pharmacology ; Biology ; Brain - drug effects ; Brain - physiopathology ; Brain research ; Brain structure ; Brain-derived neurotrophic factor ; Depressive Disorder - drug therapy ; Depressive Disorder - physiopathology ; Depressive personality disorders ; Gene expression ; Hippocampus ; Humans ; Hypotheses ; Kinases ; Laboratories ; Life cycles ; Mental depression ; Nerve Net - physiopathology ; Neural networks ; Neurobiology ; Neuronal Plasticity - physiology ; Neurons ; Neurosciences ; Neurotransmission ; Neurotrophic factors ; Pathophysiology ; Plasticity ; Primates ; Proteins ; Psychiatry ; Rats ; Signal transduction ; Social studies ; Stress ; Stress, Psychological - physiopathology ; Synaptic plasticity ; Vulnerability</subject><ispartof>British journal of psychiatry, 2001-04, Vol.178 (4), p.299-303</ispartof><rights>Copyright © 2001 The Royal College of Psychiatrists</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-d95da7375e1c26292b1f6b27295a70542813e367c86de75630029cbe28d88c133</citedby><cites>FETCH-LOGICAL-c382t-d95da7375e1c26292b1f6b27295a70542813e367c86de75630029cbe28d88c133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,12846,27924,27925,30999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11282807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>REID, IAN C</creatorcontrib><creatorcontrib>STEWART, CAROLINE A</creatorcontrib><title>How antidepressants work: New perspectives on the pathophysiology of depressive disorder</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>New research in animals is beginning to change radically our understanding of the biology of stress and the effects of antidepressant agents.
To relate recent findings from the basic neurosciences to the pathophysiology of depressive disorder.
Drawing together findings from molecular and physiological studies in rats, social studies in primates and neuropsychological studies in humans, we review the neurotrophic and neuroplastic effects of antidepressants and stress.
Stress and antidepressants have reciprocal actions on neuronal growth and vulnerability (mediated by the expression of neurotrophins) and synaptic plasticity (mediated by excitatory amino acid neurotransmission) in the hippocampus and other brain structures. Stressors have the capacity to progressively disrupt both the activities of individual cells and the operating characteristics of networks of neurons throughout the life cycle, while antidepressant treatments act to reverse such injurious effects.
We propose a central role for the regulation of synaptic connectivity in the pathophysiology of depressive disorder.</description><subject>Alzheimer's disease</subject><subject>Amino acids</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - pharmacology</subject><subject>Biology</subject><subject>Brain - drug effects</subject><subject>Brain - physiopathology</subject><subject>Brain research</subject><subject>Brain structure</subject><subject>Brain-derived neurotrophic factor</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - physiopathology</subject><subject>Depressive personality disorders</subject><subject>Gene expression</subject><subject>Hippocampus</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Life cycles</subject><subject>Mental depression</subject><subject>Nerve Net - physiopathology</subject><subject>Neural networks</subject><subject>Neurobiology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neurons</subject><subject>Neurosciences</subject><subject>Neurotransmission</subject><subject>Neurotrophic factors</subject><subject>Pathophysiology</subject><subject>Plasticity</subject><subject>Primates</subject><subject>Proteins</subject><subject>Psychiatry</subject><subject>Rats</subject><subject>Signal transduction</subject><subject>Social studies</subject><subject>Stress</subject><subject>Stress, Psychological - physiopathology</subject><subject>Synaptic plasticity</subject><subject>Vulnerability</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0E1LAzEQBuAgitaPo1eJCN62JpPNJutNxC8oelHwFnaz0-7WtonJ1tJ_b6QFxVMm8MzL8BJyytmQ8xKu6qkfcqWH-RDKcocMeK4g43khd8mAMaYyDpIdkMMYp-krclD75IBz0KCZGpD3R7ei1aLvGvQBY0xjpCsXPq7pM66oxxA92r77wkjdgvYtUl_1rfPtOnZu5iZr6sZ0u5wUbbroQoPhmOyNq1nEk-17RN7u715vH7PRy8PT7c0os0JDnzWlbCollERuoYASaj4ualBQykoxmYPmAkWhrC4aVLIQjEFpawTdaG25EEfkcpPrg_tcYuzNvIsWZ7NqgW4ZjVKMl0LlCV78g1O3DIt0mwHBpdS6AEgq2ygbXIwBx8aHbl6FteHM_BRuUuEmFW5ykwpP_mybuqzn2PzqbcMJnG9A203aVRfQBOvj2rZ_Qr4BaxeG7A</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>REID, IAN C</creator><creator>STEWART, CAROLINE A</creator><general>RCP</general><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7TK</scope><scope>7XB</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>How antidepressants work: New perspectives on the pathophysiology of depressive disorder</title><author>REID, IAN C ; STEWART, CAROLINE A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-d95da7375e1c26292b1f6b27295a70542813e367c86de75630029cbe28d88c133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Alzheimer's disease</topic><topic>Amino acids</topic><topic>Animal cognition</topic><topic>Animals</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - pharmacology</topic><topic>Biology</topic><topic>Brain - drug effects</topic><topic>Brain - physiopathology</topic><topic>Brain research</topic><topic>Brain structure</topic><topic>Brain-derived neurotrophic factor</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - physiopathology</topic><topic>Depressive personality disorders</topic><topic>Gene expression</topic><topic>Hippocampus</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Life cycles</topic><topic>Mental depression</topic><topic>Nerve Net - physiopathology</topic><topic>Neural networks</topic><topic>Neurobiology</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neurons</topic><topic>Neurosciences</topic><topic>Neurotransmission</topic><topic>Neurotrophic factors</topic><topic>Pathophysiology</topic><topic>Plasticity</topic><topic>Primates</topic><topic>Proteins</topic><topic>Psychiatry</topic><topic>Rats</topic><topic>Signal transduction</topic><topic>Social studies</topic><topic>Stress</topic><topic>Stress, Psychological - physiopathology</topic><topic>Synaptic plasticity</topic><topic>Vulnerability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>REID, IAN C</creatorcontrib><creatorcontrib>STEWART, CAROLINE A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>Psychology Database</collection><collection>ProQuest Research Library</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>REID, IAN C</au><au>STEWART, CAROLINE A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How antidepressants work: New perspectives on the pathophysiology of depressive disorder</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>178</volume><issue>4</issue><spage>299</spage><epage>303</epage><pages>299-303</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><abstract>New research in animals is beginning to change radically our understanding of the biology of stress and the effects of antidepressant agents.
To relate recent findings from the basic neurosciences to the pathophysiology of depressive disorder.
Drawing together findings from molecular and physiological studies in rats, social studies in primates and neuropsychological studies in humans, we review the neurotrophic and neuroplastic effects of antidepressants and stress.
Stress and antidepressants have reciprocal actions on neuronal growth and vulnerability (mediated by the expression of neurotrophins) and synaptic plasticity (mediated by excitatory amino acid neurotransmission) in the hippocampus and other brain structures. Stressors have the capacity to progressively disrupt both the activities of individual cells and the operating characteristics of networks of neurons throughout the life cycle, while antidepressant treatments act to reverse such injurious effects.
We propose a central role for the regulation of synaptic connectivity in the pathophysiology of depressive disorder.</abstract><cop>England</cop><pub>RCP</pub><pmid>11282807</pmid><doi>10.1192/bjp.178.4.299</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Cambridge Journals Online; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Alzheimer's disease Amino acids Animal cognition Animals Antidepressants Antidepressive Agents - pharmacology Biology Brain - drug effects Brain - physiopathology Brain research Brain structure Brain-derived neurotrophic factor Depressive Disorder - drug therapy Depressive Disorder - physiopathology Depressive personality disorders Gene expression Hippocampus Humans Hypotheses Kinases Laboratories Life cycles Mental depression Nerve Net - physiopathology Neural networks Neurobiology Neuronal Plasticity - physiology Neurons Neurosciences Neurotransmission Neurotrophic factors Pathophysiology Plasticity Primates Proteins Psychiatry Rats Signal transduction Social studies Stress Stress, Psychological - physiopathology Synaptic plasticity Vulnerability |
| title | How antidepressants work: New perspectives on the pathophysiology of depressive disorder |
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