Caspase-Dependent Cytosolic Release of Cytochrome c and Membrane Translocation of Bax in p53-Induced Apoptosis

Activation of p53 induces apoptosis in various cell types. However, the mechanism by which p53 induces apoptosis is still unclear. We reported previously that the activation of a temperature-sensitive mutant p53 (p53138Val) induced activation of caspase 3 and apoptosis in Jurkat cells. To elucidate...

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