Pharmacological profile of adenosine A2 receptor in PC12 cells

The PC12 cell line, a clone isolated from a pheochromocytoma tumor of rat adrenal medulla, was shown to exclusively contain stimulatory adenosine (A2) receptors linked to adenylate cyclase (AC). AC was stimulated 6-7 fold by several agonists with a rank order of potency of 5'-N-Ethyl carboxamid...

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Veröffentlicht in:	Life sciences (1973) 1986-09, Vol.39 (12), p.1059-1067
Hauptverfasser:	NORONHA-BLOB, L, MARSHALL, R. P, KINNIER, W. J, U'PRICHARD, D. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenylyl Cyclase Inhibitors Adenylyl Cyclases - analysis Adrenal Gland Neoplasms - analysis Animal tumors. Experimental tumors Animals Biological and medical sciences Cell Line Cell Membrane - enzymology Colforsin - antagonists & inhibitors Colforsin - pharmacology Experimental endocrine tumors Medical sciences Membrane Proteins - analysis Neoplasm Proteins - analysis Pheochromocytoma - analysis Rats Receptors, Cell Surface - classification Receptors, Cell Surface - drug effects Receptors, Purinergic Stimulation, Chemical Tumors
Online-Zugang:	Volltext
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