Modification of experimental post-subarachnoid hemorrhage vasculopathy with intracisternal plasmin
Utilizing a double subarachnoid blood injection model in pigs, we have evaluated the protective effect of the intracisternal injection of the thrombolytic agent, plasmin, in preventing the secondary intracranial arteriopathy seen after artificial subarachnoid hemorrhage in untreated animals. Twelve...
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| Veröffentlicht in: | Neurosurgery 1986-07, Vol.19 (1), p.20-25 |
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| container_title | Neurosurgery |
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| creator | ALKSNE, J. F BRANSON, P. J BAILEY, M |
| description | Utilizing a double subarachnoid blood injection model in pigs, we have evaluated the protective effect of the intracisternal injection of the thrombolytic agent, plasmin, in preventing the secondary intracranial arteriopathy seen after artificial subarachnoid hemorrhage in untreated animals. Twelve animals injected with plasmin revealed markedly less intimal proliferation and medial necrosis than were seen in control animals. These observations support the hypothesis that the persistence of clotted blood around the intracranial arteries is the cause of the vasculopathy. |
| doi_str_mv | 10.1227/00006123-198607000-00003 |
| format | Article |
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F ; BRANSON, P. J ; BAILEY, M</creator><creatorcontrib>ALKSNE, J. F ; BRANSON, P. J ; BAILEY, M</creatorcontrib><description>Utilizing a double subarachnoid blood injection model in pigs, we have evaluated the protective effect of the intracisternal injection of the thrombolytic agent, plasmin, in preventing the secondary intracranial arteriopathy seen after artificial subarachnoid hemorrhage in untreated animals. Twelve animals injected with plasmin revealed markedly less intimal proliferation and medial necrosis than were seen in control animals. These observations support the hypothesis that the persistence of clotted blood around the intracranial arteries is the cause of the vasculopathy.</description><identifier>ISSN: 0148-396X</identifier><identifier>EISSN: 1524-4040</identifier><identifier>DOI: 10.1227/00006123-198607000-00003</identifier><identifier>PMID: 2944029</identifier><identifier>CODEN: NRSRDY</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Cerebral Arterial Diseases - drug therapy ; Cerebral Arterial Diseases - pathology ; Cerebral Arterial Diseases - physiopathology ; Cisterna Magna ; Female ; Fibrinolysin - administration & dosage ; Fibrinolysin - therapeutic use ; Medical sciences ; Microscopy, Electron ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Subarachnoid Hemorrhage - drug therapy ; Subarachnoid Hemorrhage - pathology ; Subarachnoid Hemorrhage - physiopathology ; Swine</subject><ispartof>Neurosurgery, 1986-07, Vol.19 (1), p.20-25</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-91eeed7ff44ba9185b084adc9d5632d2e668d31a1185379a7460f76722c0e1703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>310,311,315,781,785,790,791,23935,23936,25145,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7895148$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2944029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ALKSNE, J. F</creatorcontrib><creatorcontrib>BRANSON, P. J</creatorcontrib><creatorcontrib>BAILEY, M</creatorcontrib><title>Modification of experimental post-subarachnoid hemorrhage vasculopathy with intracisternal plasmin</title><title>Neurosurgery</title><addtitle>Neurosurgery</addtitle><description>Utilizing a double subarachnoid blood injection model in pigs, we have evaluated the protective effect of the intracisternal injection of the thrombolytic agent, plasmin, in preventing the secondary intracranial arteriopathy seen after artificial subarachnoid hemorrhage in untreated animals. Twelve animals injected with plasmin revealed markedly less intimal proliferation and medial necrosis than were seen in control animals. These observations support the hypothesis that the persistence of clotted blood around the intracranial arteries is the cause of the vasculopathy.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cerebral Arterial Diseases - drug therapy</subject><subject>Cerebral Arterial Diseases - pathology</subject><subject>Cerebral Arterial Diseases - physiopathology</subject><subject>Cisterna Magna</subject><subject>Female</subject><subject>Fibrinolysin - administration & dosage</subject><subject>Fibrinolysin - therapeutic use</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Subarachnoid Hemorrhage - drug therapy</subject><subject>Subarachnoid Hemorrhage - pathology</subject><subject>Subarachnoid Hemorrhage - physiopathology</subject><subject>Swine</subject><issn>0148-396X</issn><issn>1524-4040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUtLxTAQhYMoen38BKELcVfN6ybNUsQXKG4U3JVpO7WRtqlJ6uPfm6vXm03InHNmmC-EZIyeMc71OU1HMS5yZgpFdXrlq5LYIgu25DKXVNJtsqBMFrkw6mWP7IfwRilTUhe7ZJcbKSk3C1I9uMa2toZo3Zi5NsOvCb0dcIzQZ5MLMQ9zBR7qbnS2yTocnPcdvGL2AaGeezdB7L6zTxu7zI4xGW2I6MdVuocw2PGQ7LTQBzxa3wfk-frq6fI2v3-8ubu8uM9rIUzMDUPERretlBUYViwrWkhoatMsleANR6WKRjBgSRLagJaKtlppzmuKTFNxQE7_-k7evc8YYjnYUGPfw4huDqXWaX1lZDIWf8bauxA8tuWUNgb_XTJarvCW_3jLDd7fkkjR4_WMuRqw2QTXPJN-stYTHOhbD2PisbHpwizTl4gf_IeEKg</recordid><startdate>19860701</startdate><enddate>19860701</enddate><creator>ALKSNE, J. F</creator><creator>BRANSON, P. J</creator><creator>BAILEY, M</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860701</creationdate><title>Modification of experimental post-subarachnoid hemorrhage vasculopathy with intracisternal plasmin</title><author>ALKSNE, J. F ; BRANSON, P. J ; BAILEY, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-91eeed7ff44ba9185b084adc9d5632d2e668d31a1185379a7460f76722c0e1703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cerebral Arterial Diseases - drug therapy</topic><topic>Cerebral Arterial Diseases - pathology</topic><topic>Cerebral Arterial Diseases - physiopathology</topic><topic>Cisterna Magna</topic><topic>Female</topic><topic>Fibrinolysin - administration & dosage</topic><topic>Fibrinolysin - therapeutic use</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Subarachnoid Hemorrhage - drug therapy</topic><topic>Subarachnoid Hemorrhage - pathology</topic><topic>Subarachnoid Hemorrhage - physiopathology</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALKSNE, J. F</creatorcontrib><creatorcontrib>BRANSON, P. J</creatorcontrib><creatorcontrib>BAILEY, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ALKSNE, J. F</au><au>BRANSON, P. J</au><au>BAILEY, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modification of experimental post-subarachnoid hemorrhage vasculopathy with intracisternal plasmin</atitle><jtitle>Neurosurgery</jtitle><addtitle>Neurosurgery</addtitle><date>1986-07-01</date><risdate>1986</risdate><volume>19</volume><issue>1</issue><spage>20</spage><epage>25</epage><pages>20-25</pages><issn>0148-396X</issn><eissn>1524-4040</eissn><coden>NRSRDY</coden><abstract>Utilizing a double subarachnoid blood injection model in pigs, we have evaluated the protective effect of the intracisternal injection of the thrombolytic agent, plasmin, in preventing the secondary intracranial arteriopathy seen after artificial subarachnoid hemorrhage in untreated animals. Twelve animals injected with plasmin revealed markedly less intimal proliferation and medial necrosis than were seen in control animals. These observations support the hypothesis that the persistence of clotted blood around the intracranial arteries is the cause of the vasculopathy.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>2944029</pmid><doi>10.1227/00006123-198607000-00003</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-396X |
| ispartof | Neurosurgery, 1986-07, Vol.19 (1), p.20-25 |
| issn | 0148-396X 1524-4040 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77016694 |
| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals Behavior, Animal - drug effects Biological and medical sciences Cerebral Arterial Diseases - drug therapy Cerebral Arterial Diseases - pathology Cerebral Arterial Diseases - physiopathology Cisterna Magna Female Fibrinolysin - administration & dosage Fibrinolysin - therapeutic use Medical sciences Microscopy, Electron Nervous system involvement in other diseases. Miscellaneous Neurology Subarachnoid Hemorrhage - drug therapy Subarachnoid Hemorrhage - pathology Subarachnoid Hemorrhage - physiopathology Swine |
| title | Modification of experimental post-subarachnoid hemorrhage vasculopathy with intracisternal plasmin |
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