Paradoxical effect of trifluoperazine, a calmodulin antagonist, on pepsinogen secretion

Pepsinogen secretion (PS) is modulated at the intracellular level by both cAMP and calcium ion. Cholecystokinin octapeptide (CCK-8), a potent stimulus for PS, is believed to act through calcium. The most extensively studied pathway for calcium-mediated modulation involves the formation of calcium/ca...

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Veröffentlicht in:	The Journal of surgical research 1986-06, Vol.40 (6), p.624-631
Hauptverfasser:	Modlin, I.M., Fratesi, G.R., Schafer, D.E., Zdon, M.J., Ballantyne, G.H., Tyshkov, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calmodulin - antagonists & inhibitors Colforsin - pharmacology Cyclic AMP - metabolism Dogs Dose-Response Relationship, Drug Gastric Mucosa - drug effects Gastric Mucosa - metabolism L-Lactate Dehydrogenase - metabolism Pepsinogens - metabolism Rabbits Sincalide - pharmacology Trifluoperazine - pharmacology
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