Vasoactive intestinal peptide augmentation of cholecystokinin-8-stimulated pepsinogen secretion: Evidence for dual modulation of chief cell function

Pepsinogen (PPG) secretion from chief cells (CC) is dually modulated by adenosine 3′: 5′-monophosphate (cAMP) and calcium second messenger systems. Vasoactive intestinal peptide (VIP) stimulates cellular function by elevating intracellular levels of cAMP. In contrast, cholecystokinin-8 (CCK-8) acts...

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Veröffentlicht in:	The Journal of surgical research 1986-06, Vol.40 (6), p.617-623
Hauptverfasser:	Ballantyne, G.H., Zdon, M.J., Zucker, K.A., Tyskoff, M., Fratesi, G.R., Schafer, D.E., Modlin, I.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - physiology Cyclic AMP - physiology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Gastric Mucosa - cytology Gastric Mucosa - drug effects Gastric Mucosa - metabolism Humans Pepsinogens - metabolism Rabbits Sincalide - pharmacology Stomach Vasoactive Intestinal Peptide - pharmacology Vertebrates: digestive system
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