Mutations in the pfmdr1, dhfr and dhps genes of Plasmodium falciparum are associated with in-vivo drug resistance in West Papua, Indonesia

This study (conducted in 1996–1999) examines the association of mutations in pfmdr1, dihydrofolate reductase ( dhfr) and dihydropteroate synthase ( dhps) genes of Plasmodium falciparum with in-vivo drug resistance in West Papua, Indonesia. Initially, 85 patients infected with P. falciparum were trea...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Transactions of the Royal Society of Tropical Medicine and Hygiene 2001, Vol.95 (1), p.43-49
Hauptverfasser:	Nagesha, Hadya S., Din-Syafruddin, Casey, Gerard J., Susanti, Augustina I., Fryauff, David J., Reeder, John C., Cowman, Alan F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - therapeutic use ATP-Binding Cassette Transporters Biological and medical sciences chloroquine dhfr dhps Dihydropteroate Synthase - genetics Drug Combinations drug resistance Drug Resistance, Microbial Human protozoal diseases Indonesia Indonesia - epidemiology Infectious diseases Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - epidemiology Malaria, Falciparum - genetics Medical sciences Mutation - genetics Parasitic diseases pfmdr1 Plasmodium falciparum Plasmodium falciparum - genetics Polymerase Chain Reaction - methods Polymorphism, Restriction Fragment Length Protozoal diseases Protozoan Proteins - genetics Pyrimethamine - therapeutic use pyrimethamine-sulfadoxine Sulfadoxine - therapeutic use Tetrahydrofolate Dehydrogenase - genetics Tropical medicine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!