Gene regulation mediated by calcium signals in T lymphocytes

Modulation of many signaling pathways in antigen-stimulated T and B cells results in global changes in gene expression. Here we investigate the contribution of calcium signaling to gene expression in T cells using cell lines from two severe-combined immunodeficiency patients with several cytokine de...

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Veröffentlicht in:	Nature immunology 2001-04, Vol.2 (4), p.316-324
Hauptverfasser:	Feske, Stefan, Giltnane, Jena, Dolmetsch, Ricardo, Staudt, Louis M., Rao, Anjana
Format:	Artikel
Sprache:	eng
Schlagworte:	B-Lymphocytes - metabolism Biomedical and Life Sciences Biomedicine Calcineurin - metabolism Calcium Calcium Signaling Cell Line Cytokines - deficiency Deoxyribonucleic acid DNA DNA-Binding Proteins - metabolism Fibroblasts - metabolism Gene Expression Profiling Gene Expression Regulation Humans Immunology Infectious Diseases Lymphocyte Activation Lymphocytes NF-AT protein NFATC Transcription Factors Nuclear Proteins Oligonucleotide Array Sequence Analysis Severe Combined Immunodeficiency - genetics Severe Combined Immunodeficiency - immunology Severe Combined Immunodeficiency - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism Transcription Factors - metabolism
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