Influence of treatment delay on long-term left ventricular function in patients with acute myocardial infarction successfully treated with primary angioplasty

Background Myocardial salvage has been shown to be dependent on the time elapsed from the onset of acute myocardial infarction (AMI) to reperfusion. The aim of this study was to evaluate the importance of time to reperfusion for left ventricular function recovery after primary angioplasty (percutane...

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Veröffentlicht in:The American heart journal 2001-04, Vol.141 (4), p.603-609
Hauptverfasser: Sheiban, Imad, Fragasso, Gabriele, Lu, Chunzeng, Tonni, Silvia, Trevi, Gian Paolo, Chierchia, Sergio L.
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container_end_page 609
container_issue 4
container_start_page 603
container_title The American heart journal
container_volume 141
creator Sheiban, Imad
Fragasso, Gabriele
Lu, Chunzeng
Tonni, Silvia
Trevi, Gian Paolo
Chierchia, Sergio L.
description Background Myocardial salvage has been shown to be dependent on the time elapsed from the onset of acute myocardial infarction (AMI) to reperfusion. The aim of this study was to evaluate the importance of time to reperfusion for left ventricular function recovery after primary angioplasty (percutaneous transluminal coronary angioplasty [PTCA]) for AMI. Methods Ninety-five patients undergoing long-term successful PTCA for AMI were studied. Echocardiography was performed before and 3, 7, 30, 90, and 180 days after PTCA. End-diastolic volume index (EDVI) and end-systolic volume index (ESVI), ejection fraction, and left ventricular wall motion score index (WMSI) were evaluated. Results Patients were divided into group A, 23 patients reperfused within 2 hours; group B, 32 patients reperfused between 2 and 4 hours; group C, 22 patients reperfused between 4 and 6 hours; and group D, 18 patients reperfused between 6 and 12 hours. Both EDVI and ESVI were reduced in groups A and B at 90 days. Groups C and D did not show any changes of EDVI and ESVI at any stage throughout the study. Ejection fraction improved only in groups A and B at 30, 90, and 180 days. At study entry, WMSI was similar in all groups. After 7 days, in group A and in group B, WMSI was improved, no changes were observed in group C, and a mild deterioration was observed in group D at 3 and 7 days. Subsequent evaluations showed progressive improvement of WMSI in all groups. Conclusions Myocardial salvage is achieved only in patients revascularized within 4 hours from AMI onset. However, revascularization after 6 hours may be worthwhile by preventing ventricular remodeling. (Am Heart J 2001;141:603-9.)
doi_str_mv 10.1067/mhj.2001.113575
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The aim of this study was to evaluate the importance of time to reperfusion for left ventricular function recovery after primary angioplasty (percutaneous transluminal coronary angioplasty [PTCA]) for AMI. Methods Ninety-five patients undergoing long-term successful PTCA for AMI were studied. Echocardiography was performed before and 3, 7, 30, 90, and 180 days after PTCA. End-diastolic volume index (EDVI) and end-systolic volume index (ESVI), ejection fraction, and left ventricular wall motion score index (WMSI) were evaluated. Results Patients were divided into group A, 23 patients reperfused within 2 hours; group B, 32 patients reperfused between 2 and 4 hours; group C, 22 patients reperfused between 4 and 6 hours; and group D, 18 patients reperfused between 6 and 12 hours. Both EDVI and ESVI were reduced in groups A and B at 90 days. Groups C and D did not show any changes of EDVI and ESVI at any stage throughout the study. Ejection fraction improved only in groups A and B at 30, 90, and 180 days. At study entry, WMSI was similar in all groups. After 7 days, in group A and in group B, WMSI was improved, no changes were observed in group C, and a mild deterioration was observed in group D at 3 and 7 days. Subsequent evaluations showed progressive improvement of WMSI in all groups. Conclusions Myocardial salvage is achieved only in patients revascularized within 4 hours from AMI onset. However, revascularization after 6 hours may be worthwhile by preventing ventricular remodeling. (Am Heart J 2001;141:603-9.)</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1067/mhj.2001.113575</identifier><identifier>PMID: 11275927</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Angioplasty, Balloon, Coronary ; Biological and medical sciences ; Cardiology. Vascular system ; Coronary Angiography ; Coronary heart disease ; Female ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Prognosis ; Time Factors ; Ventricular Function, Left</subject><ispartof>The American heart journal, 2001-04, Vol.141 (4), p.603-609</ispartof><rights>2001 Mosby, Inc.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-c4febafd97ec9d150454c2210c53c3ae5ec2c4e59abff27983a695b17368e22d3</citedby><cites>FETCH-LOGICAL-c371t-c4febafd97ec9d150454c2210c53c3ae5ec2c4e59abff27983a695b17368e22d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1067/mhj.2001.113575$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=985099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11275927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheiban, Imad</creatorcontrib><creatorcontrib>Fragasso, Gabriele</creatorcontrib><creatorcontrib>Lu, Chunzeng</creatorcontrib><creatorcontrib>Tonni, Silvia</creatorcontrib><creatorcontrib>Trevi, Gian Paolo</creatorcontrib><creatorcontrib>Chierchia, Sergio L.</creatorcontrib><title>Influence of treatment delay on long-term left ventricular function in patients with acute myocardial infarction successfully treated with primary angioplasty</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Background Myocardial salvage has been shown to be dependent on the time elapsed from the onset of acute myocardial infarction (AMI) to reperfusion. The aim of this study was to evaluate the importance of time to reperfusion for left ventricular function recovery after primary angioplasty (percutaneous transluminal coronary angioplasty [PTCA]) for AMI. Methods Ninety-five patients undergoing long-term successful PTCA for AMI were studied. Echocardiography was performed before and 3, 7, 30, 90, and 180 days after PTCA. End-diastolic volume index (EDVI) and end-systolic volume index (ESVI), ejection fraction, and left ventricular wall motion score index (WMSI) were evaluated. Results Patients were divided into group A, 23 patients reperfused within 2 hours; group B, 32 patients reperfused between 2 and 4 hours; group C, 22 patients reperfused between 4 and 6 hours; and group D, 18 patients reperfused between 6 and 12 hours. Both EDVI and ESVI were reduced in groups A and B at 90 days. Groups C and D did not show any changes of EDVI and ESVI at any stage throughout the study. Ejection fraction improved only in groups A and B at 30, 90, and 180 days. At study entry, WMSI was similar in all groups. After 7 days, in group A and in group B, WMSI was improved, no changes were observed in group C, and a mild deterioration was observed in group D at 3 and 7 days. Subsequent evaluations showed progressive improvement of WMSI in all groups. Conclusions Myocardial salvage is achieved only in patients revascularized within 4 hours from AMI onset. However, revascularization after 6 hours may be worthwhile by preventing ventricular remodeling. (Am Heart J 2001;141:603-9.)</description><subject>Adult</subject><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary Angiography</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - therapy</subject><subject>Prognosis</subject><subject>Time Factors</subject><subject>Ventricular Function, Left</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U1r3DAQBmBRWppN2nNvRVDozRtJtizrWEI_AoFe2rPQjkeJgixvJTnFf6a_tVq8NKeehJhnRoNeQt5xtuesV9fTw-NeMMb3nLdSyRdkx5lWTa-67iXZMcZEMyjWXpDLnB_rtRdD_5pccC6U1ELtyJ_b6MKCEZDOjpaEtkwYCx0x2JXOkYY53jcF00QDukKfajF5WIJN1C0Riq_GR3q0xddSpr99eaAWloJ0WmewafQ2VOFs2nBeADBnt4Swbg_iuHUdk59sWqmN934-BpvL-oa8cjZkfHs-r8jPL59_3Hxr7r5_vb35dNdAq3hpoHN4sG7UCkGPXLJOdiAEZyBbaC1KBAEdSm0Pzgmlh9b2Wh64avsBhRjbK_Jxm3tM868FczGTz4Ah2Ijzko1SjAutZYXXG4Q055zQmfPWhjNzisTUSMwpErNFUjven0cvhwnHZ3_OoIIPZ2Az2OCSjeDzP6cHybSuSm8K6zc8eUwmgz_lNvqEUMw4-_-u8BcyCKyX</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Sheiban, Imad</creator><creator>Fragasso, Gabriele</creator><creator>Lu, Chunzeng</creator><creator>Tonni, Silvia</creator><creator>Trevi, Gian Paolo</creator><creator>Chierchia, Sergio L.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Influence of treatment delay on long-term left ventricular function in patients with acute myocardial infarction successfully treated with primary angioplasty</title><author>Sheiban, Imad ; Fragasso, Gabriele ; Lu, Chunzeng ; Tonni, Silvia ; Trevi, Gian Paolo ; Chierchia, Sergio L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-c4febafd97ec9d150454c2210c53c3ae5ec2c4e59abff27983a695b17368e22d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary Angiography</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - therapy</topic><topic>Prognosis</topic><topic>Time Factors</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheiban, Imad</creatorcontrib><creatorcontrib>Fragasso, Gabriele</creatorcontrib><creatorcontrib>Lu, Chunzeng</creatorcontrib><creatorcontrib>Tonni, Silvia</creatorcontrib><creatorcontrib>Trevi, Gian Paolo</creatorcontrib><creatorcontrib>Chierchia, Sergio L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheiban, Imad</au><au>Fragasso, Gabriele</au><au>Lu, Chunzeng</au><au>Tonni, Silvia</au><au>Trevi, Gian Paolo</au><au>Chierchia, Sergio L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of treatment delay on long-term left ventricular function in patients with acute myocardial infarction successfully treated with primary angioplasty</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>141</volume><issue>4</issue><spage>603</spage><epage>609</epage><pages>603-609</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Background Myocardial salvage has been shown to be dependent on the time elapsed from the onset of acute myocardial infarction (AMI) to reperfusion. The aim of this study was to evaluate the importance of time to reperfusion for left ventricular function recovery after primary angioplasty (percutaneous transluminal coronary angioplasty [PTCA]) for AMI. Methods Ninety-five patients undergoing long-term successful PTCA for AMI were studied. Echocardiography was performed before and 3, 7, 30, 90, and 180 days after PTCA. End-diastolic volume index (EDVI) and end-systolic volume index (ESVI), ejection fraction, and left ventricular wall motion score index (WMSI) were evaluated. Results Patients were divided into group A, 23 patients reperfused within 2 hours; group B, 32 patients reperfused between 2 and 4 hours; group C, 22 patients reperfused between 4 and 6 hours; and group D, 18 patients reperfused between 6 and 12 hours. Both EDVI and ESVI were reduced in groups A and B at 90 days. Groups C and D did not show any changes of EDVI and ESVI at any stage throughout the study. Ejection fraction improved only in groups A and B at 30, 90, and 180 days. At study entry, WMSI was similar in all groups. After 7 days, in group A and in group B, WMSI was improved, no changes were observed in group C, and a mild deterioration was observed in group D at 3 and 7 days. Subsequent evaluations showed progressive improvement of WMSI in all groups. Conclusions Myocardial salvage is achieved only in patients revascularized within 4 hours from AMI onset. However, revascularization after 6 hours may be worthwhile by preventing ventricular remodeling. (Am Heart J 2001;141:603-9.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>11275927</pmid><doi>10.1067/mhj.2001.113575</doi><tpages>7</tpages></addata></record>
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subjects Adult
Aged
Angioplasty, Balloon, Coronary
Biological and medical sciences
Cardiology. Vascular system
Coronary Angiography
Coronary heart disease
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - physiopathology
Myocardial Infarction - therapy
Prognosis
Time Factors
Ventricular Function, Left
title Influence of treatment delay on long-term left ventricular function in patients with acute myocardial infarction successfully treated with primary angioplasty
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