Three New Triterpenes from the Seeds of Combretum quadrangulare and Their Hepatoprotective Activity
Three new triterpenes of the lupane type, 2α,6β-dihydroxybetulinic acid (1) and 6β-hydroxyhovenic acid (2), and an oleanane type, 6β-hydroxyarjunic acid (3), together with several known compounds, have been isolated from the MeOH extract of the seeds of Combretum quadrangulare. The structures of the...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2001-03, Vol.64 (3), p.360-363 |
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| container_end_page | 363 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 64 |
| creator | Adnyana, I Ketut Tezuka, Yasuhiro Banskota, Arjun H Tran, Kim Qui Kadota, Shigetoshi |
| description | Three new triterpenes of the lupane type, 2α,6β-dihydroxybetulinic acid (1) and 6β-hydroxyhovenic acid (2), and an oleanane type, 6β-hydroxyarjunic acid (3), together with several known compounds, have been isolated from the MeOH extract of the seeds of Combretum quadrangulare. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and their hepatoprotective activities were tested for d-GalN/TNF-α-induced cell death in primary cultured mouse hepatocytes. |
| doi_str_mv | 10.1021/np000486x |
| format | Article |
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Nat. Prod</addtitle><description>Three new triterpenes of the lupane type, 2α,6β-dihydroxybetulinic acid (1) and 6β-hydroxyhovenic acid (2), and an oleanane type, 6β-hydroxyarjunic acid (3), together with several known compounds, have been isolated from the MeOH extract of the seeds of Combretum quadrangulare. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and their hepatoprotective activities were tested for d-GalN/TNF-α-induced cell death in primary cultured mouse hepatocytes.</description><subject>Asia</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Liver - drug effects</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2001-03, Vol.64 (3), p.360-363 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Asia Biological and medical sciences General pharmacology Liver - drug effects Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Protective Agents Rosales - chemistry Seeds - chemistry Trees - chemistry Triterpenes - isolation & purification |
| title | Three New Triterpenes from the Seeds of Combretum quadrangulare and Their Hepatoprotective Activity |
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