Neuropsychological change in schizophrenia after 6 weeks of clozapine
Neuropsychological change after 6 weeks of clozapine treatment was examined in 18 treatment-refractory patients to test anticipated domain-specific cognitive improvements. The first aim of this study was to test the assumption that increased homogeneity of sample and treatment would yield an experim...
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| Veröffentlicht in: | Schizophrenia research 2001-03, Vol.48 (1), p.57-67 |
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| container_title | Schizophrenia research |
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| creator | Purdon, Scot E Labelle, Alain Boulay, Luc |
| description | Neuropsychological change after 6
weeks of clozapine treatment was examined in 18 treatment-refractory patients to test anticipated domain-specific cognitive improvements. The first aim of this study was to test the assumption that increased homogeneity of sample and treatment would yield an experimental design with sufficient sensitivity to detect general intellectual changes with clozapine that were not apparent in one previous investigation. The second aim was to test predictions derived from a domain-specific review of all other investigations with clozapine suggesting salient gains on tests sensitive to motor and mental speed, visual spatial manipulation, and new learning of verbal material. The results showed that the comprehensive neuropsychological test battery was sensitive to general cognitive changes with clozapine, and supported the hypothesized domain-specific gains on tests of motor and mental speed, visual spatial manipulation and new verbal learning. Novel gains were also apparent on tests of new learning with nonverbal material. The results are discussed in relation to aspects of experimental design necessary for the evaluation of prospective medication-induced changes in cognitive skill, particularly in future investigations designed to differentiate between second-generation antipsychotic medications. |
| doi_str_mv | 10.1016/S0920-9964(00)00101-8 |
| format | Article |
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weeks of clozapine treatment was examined in 18 treatment-refractory patients to test anticipated domain-specific cognitive improvements. The first aim of this study was to test the assumption that increased homogeneity of sample and treatment would yield an experimental design with sufficient sensitivity to detect general intellectual changes with clozapine that were not apparent in one previous investigation. The second aim was to test predictions derived from a domain-specific review of all other investigations with clozapine suggesting salient gains on tests sensitive to motor and mental speed, visual spatial manipulation, and new learning of verbal material. The results showed that the comprehensive neuropsychological test battery was sensitive to general cognitive changes with clozapine, and supported the hypothesized domain-specific gains on tests of motor and mental speed, visual spatial manipulation and new verbal learning. 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Drug treatments</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Research Design</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - drug therapy</subject><subject>Sensitivity and Specificity</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MtKAzEUgOEgiq3VR1AGBNHF6EnmkslKpNQLFF2o65BmTtrodDImrdI-vdMLdekqEL7kHH5CTilcU6D5zSsIBrEQeXoJcAXQXsbFHunSjCcxy0Dsk-6OdMhRCB_Qqgz4IelQynhBs7RLBs84964JCz1xlRtbrapIT1Q9xsjWUdATu3TNxGNtVaTMDH2URz-InyFyJtKVW6rG1nhMDoyqAp5szx55vx-89R_j4cvDU_9uGOukELMYDSZmlGBhRlowNCrPjShNRllJS6PKtN2pVCov8iJBxo1SyAWHLNWp5hkrkh652PzbePc1xzCTUxs0VpWq0c2D5Bwog5S1MNtA7V0IHo1svJ0qv5AU5KqfXPeTqzgSQK77ydWAs-2A-WiK5d-rbbAWnG-BCm0r41Wtbdg5kQpa8FbdbhS2Mb4tehm0xVpjaT3qmSyd_WeRX7bEjPk</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Purdon, Scot E</creator><creator>Labelle, Alain</creator><creator>Boulay, Luc</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Neuropsychological change in schizophrenia after 6 weeks of clozapine</title><author>Purdon, Scot E ; Labelle, Alain ; Boulay, Luc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-efe3fb3e8fbc92efa66f9df512d1dfad4815daa68683e27faae797054c4c75283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Clozapine</topic><topic>Clozapine - pharmacology</topic><topic>Cognition</topic><topic>Cognition - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuroleptic</topic><topic>Neuropharmacology</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Antipsychotic Agents - pharmacology Biological and medical sciences Clozapine Clozapine - pharmacology Cognition Cognition - drug effects Female Humans Male Medical sciences Neuroleptic Neuropharmacology Neuropsychological Tests Neuropsychology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Research Design Schizophrenia Schizophrenia - diagnosis Schizophrenia - drug therapy Sensitivity and Specificity |
| title | Neuropsychological change in schizophrenia after 6 weeks of clozapine |
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