The BBXB Motif of RANTES Is the Principal Site for Heparin Binding and Controls Receptor Selectivity

The chemokine RANTES (regulated on activation normal T cell expressed and secreted; CCL5) binds selectively to glycosaminoglycans (GAGs) such as heparin, chondroitin sulfate, and dermatan sulfate. The primary sequence of RANTES contains two clusters of basic residues, 44RKNR47 and55KKWVR59. The firs...

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Veröffentlicht in:	The Journal of biological chemistry 2001-04, Vol.276 (14), p.10620-10626
Hauptverfasser:	Proudfoot, Amanda E.I., Fritchley, Sarah, Borlat, Frédéric, Shaw, Jeffrey P., Vilbois, Francis, Zwahlen, Catherine, Trkola, Alexandra, Marchant, David, Clapham, Paul R., Wells, Timothy N.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - genetics Chemokine CCL5 - chemistry Chemokine CCL5 - genetics Chemokine CCL5 - metabolism CHO Cells Cricetinae Heparin - metabolism Mutation Protein Binding - genetics Receptors, CCR5 Receptors, Chemokine - chemistry Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Transfection
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