The efficacy and safety of a combination benzoyl peroxide/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide/erythromycin combination product
Topical clindamycin and benzoyl peroxide have each demonstrated clinical efficacy in the treatment of acne vulgaris. When used in tandem, they promise greater efficacy than either individual agent through their antibacterial and anti-inflammatory effects. To determine the efficacy and safety of comb...
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| Veröffentlicht in: | Journal of cutaneous medicine and surgery 2001, Vol.5 (1), p.37-42 |
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| creator | LEYDEN, James J HICKMAN, Janet G JARRATT, Michael T STEWART, Daniel M LEVY, Sharon F |
| description | Topical clindamycin and benzoyl peroxide have each demonstrated clinical efficacy in the treatment of acne vulgaris. When used in tandem, they promise greater efficacy than either individual agent through their antibacterial and anti-inflammatory effects.
To determine the efficacy and safety of combination benzoyl peroxide/ clindamycin compared with benzoyl peroxide or benzoyl peroxide/erythromycin in the treatment of acne.
In this randomized, 10-week, multicenter, single-blind trial, 492 patients with moderate to moderately severe acne were treated twice daily with 5% benzoyl peroxide/1% clindamycin, 5% benzoyl peroxide, or 5% benzoyl peroxide/3% erythromycin and assessed every 2 weeks.
Compared with benzoyl peroxide, benzoyl peroxide/clindamycin demonstrated significantly greater reductions in inflammatory lesions (p = 0.04) and significantly greater overall improvement as assessed by physicians (p < or = 0.04) and patients (p < 0.001). Benzoyl peroxide/clindamycin demonstrated a nonsignificant trend for greater efficacy compared to benzoyl peroxide/erythromycin. Dry skin was the most frequent (< or = 7.3%) adverse event with all three therapies.
Benzoyl peroxide/clindamycin demonstrated improved efficacy and similar tolerability; to benzoyl peroxide used alone and was similar to benzoyl peroxide/ erythromycin, making this combination product an effective alternative antimicrobial therapy for acne. |
| doi_str_mv | 10.1177/120347540100500109 |
| format | Article |
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To determine the efficacy and safety of combination benzoyl peroxide/ clindamycin compared with benzoyl peroxide or benzoyl peroxide/erythromycin in the treatment of acne.
In this randomized, 10-week, multicenter, single-blind trial, 492 patients with moderate to moderately severe acne were treated twice daily with 5% benzoyl peroxide/1% clindamycin, 5% benzoyl peroxide, or 5% benzoyl peroxide/3% erythromycin and assessed every 2 weeks.
Compared with benzoyl peroxide, benzoyl peroxide/clindamycin demonstrated significantly greater reductions in inflammatory lesions (p = 0.04) and significantly greater overall improvement as assessed by physicians (p < or = 0.04) and patients (p < 0.001). Benzoyl peroxide/clindamycin demonstrated a nonsignificant trend for greater efficacy compared to benzoyl peroxide/erythromycin. Dry skin was the most frequent (< or = 7.3%) adverse event with all three therapies.
Benzoyl peroxide/clindamycin demonstrated improved efficacy and similar tolerability; to benzoyl peroxide used alone and was similar to benzoyl peroxide/ erythromycin, making this combination product an effective alternative antimicrobial therapy for acne.</description><identifier>ISSN: 1203-4754</identifier><identifier>EISSN: 1615-7109</identifier><identifier>DOI: 10.1177/120347540100500109</identifier><identifier>PMID: 11281433</identifier><language>eng</language><publisher>Hamilton, ON: Decker</publisher><subject>Acne Vulgaris - drug therapy ; Administration, Topical ; Adolescent ; Anti-Bacterial Agents - administration & dosage ; Benzoyl Peroxide - administration & dosage ; Biological and medical sciences ; Clindamycin - administration & dosage ; Drug Combinations ; Erythromycin - administration & dosage ; Female ; Gels ; Humans ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Single-Blind Method ; Skin, nail, hair, dermoskeleton</subject><ispartof>Journal of cutaneous medicine and surgery, 2001, Vol.5 (1), p.37-42</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Springer Science & Business Media Jan 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,4036,4037,23911,23912,25120,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13605765$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11281433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEYDEN, James J</creatorcontrib><creatorcontrib>HICKMAN, Janet G</creatorcontrib><creatorcontrib>JARRATT, Michael T</creatorcontrib><creatorcontrib>STEWART, Daniel M</creatorcontrib><creatorcontrib>LEVY, Sharon F</creatorcontrib><title>The efficacy and safety of a combination benzoyl peroxide/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide/erythromycin combination product</title><title>Journal of cutaneous medicine and surgery</title><addtitle>J Cutan Med Surg</addtitle><description>Topical clindamycin and benzoyl peroxide have each demonstrated clinical efficacy in the treatment of acne vulgaris. When used in tandem, they promise greater efficacy than either individual agent through their antibacterial and anti-inflammatory effects.
To determine the efficacy and safety of combination benzoyl peroxide/ clindamycin compared with benzoyl peroxide or benzoyl peroxide/erythromycin in the treatment of acne.
In this randomized, 10-week, multicenter, single-blind trial, 492 patients with moderate to moderately severe acne were treated twice daily with 5% benzoyl peroxide/1% clindamycin, 5% benzoyl peroxide, or 5% benzoyl peroxide/3% erythromycin and assessed every 2 weeks.
Compared with benzoyl peroxide, benzoyl peroxide/clindamycin demonstrated significantly greater reductions in inflammatory lesions (p = 0.04) and significantly greater overall improvement as assessed by physicians (p < or = 0.04) and patients (p < 0.001). Benzoyl peroxide/clindamycin demonstrated a nonsignificant trend for greater efficacy compared to benzoyl peroxide/erythromycin. Dry skin was the most frequent (< or = 7.3%) adverse event with all three therapies.
Benzoyl peroxide/clindamycin demonstrated improved efficacy and similar tolerability; to benzoyl peroxide used alone and was similar to benzoyl peroxide/ erythromycin, making this combination product an effective alternative antimicrobial therapy for acne.</description><subject>Acne Vulgaris - drug therapy</subject><subject>Administration, Topical</subject><subject>Adolescent</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Benzoyl Peroxide - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Clindamycin - administration & dosage</subject><subject>Drug Combinations</subject><subject>Erythromycin - administration & dosage</subject><subject>Female</subject><subject>Gels</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Single-Blind Method</subject><subject>Skin, nail, hair, dermoskeleton</subject><issn>1203-4754</issn><issn>1615-7109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkctu1jAQhS0EoqXwAiyQhQS7UF_jeFlVXCpVYlPWkWOP-V0ldmonasND9Rnr0h-1opuZWXxzzugMQu8p-UKpUseUES6UFIQSIkmt-gU6pC2VjarzyzpXoLknDtCbUi5JZagUr9EBpayjgvNDdHuxAwzeB2vshk10uBgPy4aTxwbbNA0hmiWkiAeIf9I24hlyugkOju0YojPTZkPES5qrwoh_w3i_NJsMDl-HZfdsDZsxRfjrZJ5rQt6WXU4Pok_d55zcape36JU3Y4F3-36Efn37enH6ozn_-f3s9OS8manSS8M187ptKaNGcyE717VgBUgnpCYDtdZ7wWQL0oAeiDLSgaAcrPYtcMUYP0KfH3Sr79UKZemnUCyMo4mQ1tIrVaOsWVbw43_gZVpzrLf1jOmuk53kFfqwh9ZhAtfPOUwmb_2_N1Tg0x4wpcbos4k2lEeOt0SqVvI7qXSbEg</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>LEYDEN, James J</creator><creator>HICKMAN, Janet G</creator><creator>JARRATT, Michael T</creator><creator>STEWART, Daniel M</creator><creator>LEVY, Sharon F</creator><general>Decker</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>The efficacy and safety of a combination benzoyl peroxide/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide/erythromycin combination product</title><author>LEYDEN, James J ; HICKMAN, Janet G ; JARRATT, Michael T ; STEWART, Daniel M ; LEVY, Sharon F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p179t-392f966121a93458d86ec4e5d4590b1ccff4256e5ae9b07a5de413ec9f6e37223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acne Vulgaris - drug therapy</topic><topic>Administration, Topical</topic><topic>Adolescent</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Benzoyl Peroxide - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Clindamycin - administration & dosage</topic><topic>Drug Combinations</topic><topic>Erythromycin - administration & dosage</topic><topic>Female</topic><topic>Gels</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Single-Blind Method</topic><topic>Skin, nail, hair, dermoskeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEYDEN, James J</creatorcontrib><creatorcontrib>HICKMAN, Janet G</creatorcontrib><creatorcontrib>JARRATT, Michael T</creatorcontrib><creatorcontrib>STEWART, Daniel M</creatorcontrib><creatorcontrib>LEVY, Sharon F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEYDEN, James J</au><au>HICKMAN, Janet G</au><au>JARRATT, Michael T</au><au>STEWART, Daniel M</au><au>LEVY, Sharon F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The efficacy and safety of a combination benzoyl peroxide/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide/erythromycin combination product</atitle><jtitle>Journal of cutaneous medicine and surgery</jtitle><addtitle>J Cutan Med Surg</addtitle><date>2001</date><risdate>2001</risdate><volume>5</volume><issue>1</issue><spage>37</spage><epage>42</epage><pages>37-42</pages><issn>1203-4754</issn><eissn>1615-7109</eissn><abstract>Topical clindamycin and benzoyl peroxide have each demonstrated clinical efficacy in the treatment of acne vulgaris. When used in tandem, they promise greater efficacy than either individual agent through their antibacterial and anti-inflammatory effects.
To determine the efficacy and safety of combination benzoyl peroxide/ clindamycin compared with benzoyl peroxide or benzoyl peroxide/erythromycin in the treatment of acne.
In this randomized, 10-week, multicenter, single-blind trial, 492 patients with moderate to moderately severe acne were treated twice daily with 5% benzoyl peroxide/1% clindamycin, 5% benzoyl peroxide, or 5% benzoyl peroxide/3% erythromycin and assessed every 2 weeks.
Compared with benzoyl peroxide, benzoyl peroxide/clindamycin demonstrated significantly greater reductions in inflammatory lesions (p = 0.04) and significantly greater overall improvement as assessed by physicians (p < or = 0.04) and patients (p < 0.001). Benzoyl peroxide/clindamycin demonstrated a nonsignificant trend for greater efficacy compared to benzoyl peroxide/erythromycin. Dry skin was the most frequent (< or = 7.3%) adverse event with all three therapies.
Benzoyl peroxide/clindamycin demonstrated improved efficacy and similar tolerability; to benzoyl peroxide used alone and was similar to benzoyl peroxide/ erythromycin, making this combination product an effective alternative antimicrobial therapy for acne.</abstract><cop>Hamilton, ON</cop><pub>Decker</pub><pmid>11281433</pmid><doi>10.1177/120347540100500109</doi><tpages>6</tpages></addata></record> |
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| subjects | Acne Vulgaris - drug therapy Administration, Topical Adolescent Anti-Bacterial Agents - administration & dosage Benzoyl Peroxide - administration & dosage Biological and medical sciences Clindamycin - administration & dosage Drug Combinations Erythromycin - administration & dosage Female Gels Humans Male Medical sciences Pharmacology. Drug treatments Single-Blind Method Skin, nail, hair, dermoskeleton |
| title | The efficacy and safety of a combination benzoyl peroxide/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide/erythromycin combination product |
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