Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat

In this study, phosphatidylethanol formed by phospholipase D catalysed transphosphatidylation of phosphatidylcholine was employed as a component for preparation of liposomal carrier for oral delivery of insulin. Thermotropic behaviour of liposomes from mixtures of dipalmitoyl phosphatidylcholine and...

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Veröffentlicht in:	International journal of pharmaceutics 2001-03, Vol.216 (1), p.105-114
Hauptverfasser:	Kisel, M.A., Kulik, L.N., Tsybovsky, I.S., Vlasov, A.P., Vorob'yov, M.S., Kholodova, E.A., Zabarovskaya, Z.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Alloxan diabetes Animals Biological and medical sciences Calorimetry, Differential Scanning Chemistry, Pharmaceutical Diabetes Mellitus, Experimental - drug therapy Drug Carriers General and cellular metabolism. Vitamins General pharmacology Glycerophospholipids - chemistry Hydrolysis - drug effects Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - therapeutic use Insulin Insulin - administration & dosage Insulin - therapeutic use Liposomes Male Medical sciences Oral administration Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phosphatidylethanol Phospholipases A - chemistry Rats Rats, Wistar
Online-Zugang:	Volltext
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