Determination of captopril in pharmaceutical tablets by anion-exchange HPLC using indirect photometric detection; a study in systematic method development
The development and validation of a significantly cost effective and simpler anion-exchange high performance liquid chromatorgaphic (HPLC) procedure than the compendial methods for the analysis of captopril in tablet dosage forms using indirect photometric detection is described. A low capacity anio...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2001-04, Vol.25 (1), p.39-52 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Mirza, Tahseen Tan, Henry S.I |
| description | The development and validation of a significantly cost effective and simpler anion-exchange high performance liquid chromatorgaphic (HPLC) procedure than the compendial methods for the analysis of captopril in tablet dosage forms using indirect photometric detection is described. A low capacity anion-exchange column was used with potassium phthalate as the mobile phase marker and indirect detection at 280 nm. The chromatographic conditions were optimized using the Box and Behnken factorial experimental design. The method was precise and accurate with percent recovery (±%R.S.D.) of 99.8±0.7% (
n=12) with the spiked concentrations ranging between ±30% of the assay level. Youden and Steiner's robustness test, involving seven chosen variables, showed that the method is robust. Using the developed method, commercially available captopril tablets were assayed and the results were found to be comparable with those obtained by the compendial method. |
| doi_str_mv | 10.1016/S0731-7085(00)00462-3 |
| format | Article |
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n=12) with the spiked concentrations ranging between ±30% of the assay level. Youden and Steiner's robustness test, involving seven chosen variables, showed that the method is robust. Using the developed method, commercially available captopril tablets were assayed and the results were found to be comparable with those obtained by the compendial method.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/S0731-7085(00)00462-3</identifier><identifier>PMID: 11274857</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Angiotensin-Converting Enzyme Inhibitors - analysis ; Biological and medical sciences ; Captopril ; Captopril - analysis ; Chemistry, Pharmaceutical ; Chromatography, High Pressure Liquid - methods ; Chromatography, Ion Exchange - methods ; General pharmacology ; Indirect photometric detection ; Ion-exchange chromatography ; Medical sciences ; Pharmaceutical tablets ; Pharmacology. Drug treatments ; Photometry - methods ; Quality Control ; Reference Standards ; Reproducibility of Results ; Tablets - chemistry</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2001-04, Vol.25 (1), p.39-52</ispartof><rights>2001 Elsevier Science B.V.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-437f3539562c2c3fe9273b48724d4aeb581d57b33f501f04fdbafeaff7d9785c3</citedby><cites>FETCH-LOGICAL-c389t-437f3539562c2c3fe9273b48724d4aeb581d57b33f501f04fdbafeaff7d9785c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0731-7085(00)00462-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=925663$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11274857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mirza, Tahseen</creatorcontrib><creatorcontrib>Tan, Henry S.I</creatorcontrib><title>Determination of captopril in pharmaceutical tablets by anion-exchange HPLC using indirect photometric detection; a study in systematic method development</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>The development and validation of a significantly cost effective and simpler anion-exchange high performance liquid chromatorgaphic (HPLC) procedure than the compendial methods for the analysis of captopril in tablet dosage forms using indirect photometric detection is described. A low capacity anion-exchange column was used with potassium phthalate as the mobile phase marker and indirect detection at 280 nm. The chromatographic conditions were optimized using the Box and Behnken factorial experimental design. The method was precise and accurate with percent recovery (±%R.S.D.) of 99.8±0.7% (
n=12) with the spiked concentrations ranging between ±30% of the assay level. Youden and Steiner's robustness test, involving seven chosen variables, showed that the method is robust. Using the developed method, commercially available captopril tablets were assayed and the results were found to be comparable with those obtained by the compendial method.</description><subject>Analysis</subject><subject>Angiotensin-Converting Enzyme Inhibitors - analysis</subject><subject>Biological and medical sciences</subject><subject>Captopril</subject><subject>Captopril - analysis</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, Ion Exchange - methods</subject><subject>General pharmacology</subject><subject>Indirect photometric detection</subject><subject>Ion-exchange chromatography</subject><subject>Medical sciences</subject><subject>Pharmaceutical tablets</subject><subject>Pharmacology. Drug treatments</subject><subject>Photometry - methods</subject><subject>Quality Control</subject><subject>Reference Standards</subject><subject>Reproducibility of Results</subject><subject>Tablets - chemistry</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-L1DAUxYMo7uzqR1ACgqwP1aRpmhQfRMY_KwwoqOBbSJObnUjb1CRdnK_ipzXdGdZHn-7L75xzOQehJ5S8pIS2r74SwWgliOSXhLwgpGnrit1DGyoFq-q2-XEfbe6QM3Se0k9CCKdd8xCdUVqLRnKxQX_eQYY4-klnHyYcHDZ6zmGOfsB-wvNex1EbWLI3esBZ9wPkhPsD1lPhK_ht9nq6Bnz1ZbfFS_LTdZFZH8HkIg45jJCjN9iWGLNGvMYap7zYw2qfDinDWKINLtw-2MLdwBDmEab8CD1wekjw-HQv0PcP779tr6rd54-ftm93lWGyy1XDhGOcdbytTW2Yg64WrG-kqBvbaOi5pJaLnjHHCXWkcbbXDrRzwnZCcsMu0POj7xzDrwVSVqNPBoZBTxCWpIQgRMpOFpAfQRNDShGcKjWNOh4UJWodRd2OotbGFSHqdhTFiu7pKWDpR7D_VKcVCvDsBOhUanZRT8anO66reduuNm-OFJQybjxElYyHycCxbmWD_88jfwGBBqyg</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Mirza, Tahseen</creator><creator>Tan, Henry S.I</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Determination of captopril in pharmaceutical tablets by anion-exchange HPLC using indirect photometric detection; a study in systematic method development</title><author>Mirza, Tahseen ; Tan, Henry S.I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-437f3539562c2c3fe9273b48724d4aeb581d57b33f501f04fdbafeaff7d9785c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Analysis</topic><topic>Angiotensin-Converting Enzyme Inhibitors - analysis</topic><topic>Biological and medical sciences</topic><topic>Captopril</topic><topic>Captopril - analysis</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Chromatography, Ion Exchange - methods</topic><topic>General pharmacology</topic><topic>Indirect photometric detection</topic><topic>Ion-exchange chromatography</topic><topic>Medical sciences</topic><topic>Pharmaceutical tablets</topic><topic>Pharmacology. Drug treatments</topic><topic>Photometry - methods</topic><topic>Quality Control</topic><topic>Reference Standards</topic><topic>Reproducibility of Results</topic><topic>Tablets - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mirza, Tahseen</creatorcontrib><creatorcontrib>Tan, Henry S.I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mirza, Tahseen</au><au>Tan, Henry S.I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of captopril in pharmaceutical tablets by anion-exchange HPLC using indirect photometric detection; a study in systematic method development</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>25</volume><issue>1</issue><spage>39</spage><epage>52</epage><pages>39-52</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>The development and validation of a significantly cost effective and simpler anion-exchange high performance liquid chromatorgaphic (HPLC) procedure than the compendial methods for the analysis of captopril in tablet dosage forms using indirect photometric detection is described. 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n=12) with the spiked concentrations ranging between ±30% of the assay level. Youden and Steiner's robustness test, involving seven chosen variables, showed that the method is robust. Using the developed method, commercially available captopril tablets were assayed and the results were found to be comparable with those obtained by the compendial method.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11274857</pmid><doi>10.1016/S0731-7085(00)00462-3</doi><tpages>14</tpages></addata></record> |
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| issn | 0731-7085 1873-264X |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Analysis Angiotensin-Converting Enzyme Inhibitors - analysis Biological and medical sciences Captopril Captopril - analysis Chemistry, Pharmaceutical Chromatography, High Pressure Liquid - methods Chromatography, Ion Exchange - methods General pharmacology Indirect photometric detection Ion-exchange chromatography Medical sciences Pharmaceutical tablets Pharmacology. Drug treatments Photometry - methods Quality Control Reference Standards Reproducibility of Results Tablets - chemistry |
| title | Determination of captopril in pharmaceutical tablets by anion-exchange HPLC using indirect photometric detection; a study in systematic method development |
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