Regional Comparison of Technetium-99m DTPA Aerosol and Radioactive Gas Ventilation (Xenon and Krypton) Studies in Patients with Suspected Pulmonary Embolism

The regional distribution of [99mTc]DTPA aerosol was compared with that of 133Xe (n = 30) and krypton (n = 24) in a group of patients with suspected pulmonary embolism. All patients had an aerosol study using a recently available commercial generator system, a ventilation study with one of the gases...

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Veröffentlicht in:The Journal of nuclear medicine (1978) 1986-09, Vol.27 (9), p.1391-1396
Hauptverfasser: Ramanna, Lalitha, Alderson, Philip O, Waxman, Alan D, Berman, Daniel S, Brachman, Michael B, Kroop, Steven A, Goldsmith, Mark, Tanasescu, Doina E
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container_end_page 1396
container_issue 9
container_start_page 1391
container_title The Journal of nuclear medicine (1978)
container_volume 27
creator Ramanna, Lalitha
Alderson, Philip O
Waxman, Alan D
Berman, Daniel S
Brachman, Michael B
Kroop, Steven A
Goldsmith, Mark
Tanasescu, Doina E
description The regional distribution of [99mTc]DTPA aerosol was compared with that of 133Xe (n = 30) and krypton (n = 24) in a group of patients with suspected pulmonary embolism. All patients had an aerosol study using a recently available commercial generator system, a ventilation study with one of the gases, and perfusion imaging. Regional information was assessed visually on xenon, krypton, and aerosol studies independently by considering each lung as three equal-sized zones. In addition, gas ventilation findings peripheral to regions of aerosol turbulence ("hot spots") were evaluated. Only 64% of the zones were in complete agreement on xenon and aerosol. Most of the discordance between xenon and aerosol was accounted for by minor degrees of 133Xe washout retention in zones that appeared normal in the aerosol study. An agreement rate of 85% was noted between 81mKr and aerosol regionally. The regions of discordance between aerosol and gas studies, however, usually were associated with unimpressive perfusion defects that did not change the scintigraphic probability for pulmonary embolism in any patient. Regarding zones of aerosol hyperdeposition, 76% had associated washout abnormalities on xenon; however, there was no correlation between the presence of these abnormalities or perfusion abnormalities. The results confirm the high sensitivity of 133Xe washout imaging, but suggest that radioaerosol imaging will detect most parenchymal abnormalities associated with perfusion defects of significance.
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Regarding zones of aerosol hyperdeposition, 76% had associated washout abnormalities on xenon; however, there was no correlation between the presence of these abnormalities or perfusion abnormalities. 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source MEDLINE; EZB-FREE-00999 freely available EZB journals
subjects Adult
Aerosols
Aged
Female
Humans
Krypton
Male
Middle Aged
Pentetic Acid
Pulmonary Embolism - diagnostic imaging
Radioisotopes
Radionuclide Imaging
Technetium
Technetium Tc 99m Pentetate
Ventilation-Perfusion Ratio
Xenon Radioisotopes
title Regional Comparison of Technetium-99m DTPA Aerosol and Radioactive Gas Ventilation (Xenon and Krypton) Studies in Patients with Suspected Pulmonary Embolism
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