Insulin-like growth factors I and II in evaluation of growth retardation
Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level
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| Veröffentlicht in: | The Journal of pediatrics 1986-09, Vol.109 (3), p.428-433 |
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| container_end_page | 433 |
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| container_issue | 3 |
| container_start_page | 428 |
| container_title | The Journal of pediatrics |
| container_volume | 109 |
| creator | Rosenfeld, Ron G. Wilson, Darrell M. Lee, Phillip D.K. Hintz, Raymond L. |
| description | Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level |
| doi_str_mv | 10.1016/S0022-3476(86)80112-3 |
| format | Article |
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Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(86)80112-3</identifier><identifier>PMID: 3746530</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Biological and medical sciences ; Child ; Child, Preschool ; Endocrinopathies ; Female ; Growth Disorders - blood ; Humans ; Hypothalamus. Hypophysis. Epiphysis (diseases) ; Infant ; Insulin-Like Growth Factor I - blood ; Insulin-Like Growth Factor II - blood ; Male ; Malignant tumors ; Medical sciences ; Somatomedins - blood ; Somatomedins - deficiency</subject><ispartof>The Journal of pediatrics, 1986-09, Vol.109 (3), p.428-433</ispartof><rights>1986 The C. V. Mosby Company</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-e8ec4dafafa0e23f258fd49689411f02e2c015dfb79fea6ffe45aeab283c68b73</citedby><cites>FETCH-LOGICAL-c370t-e8ec4dafafa0e23f258fd49689411f02e2c015dfb79fea6ffe45aeab283c68b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(86)80112-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8165124$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3746530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenfeld, Ron G.</creatorcontrib><creatorcontrib>Wilson, Darrell M.</creatorcontrib><creatorcontrib>Lee, Phillip D.K.</creatorcontrib><creatorcontrib>Hintz, Raymond L.</creatorcontrib><title>Insulin-like growth factors I and II in evaluation of growth retardation</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level <7 ng/ml), 44 normal short children, and 197 children with normal height were asseyed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Growth Disorders - blood</subject><subject>Humans</subject><subject>Hypothalamus. Hypophysis. Epiphysis (diseases)</subject><subject>Infant</subject><subject>Insulin-Like Growth Factor I - blood</subject><subject>Insulin-Like Growth Factor II - blood</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Somatomedins - blood</subject><subject>Somatomedins - deficiency</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtLwzAUgIMoOi8_YdAHEX2oniRtkj6JDHUFwQf1OWTpiUa7dibtxH9v5-ZeJYFwcr5z4SNkTOGSAhVXTwCMpTyT4lyJCwWUDtEOGVEoZCoU57tktEUOyGGM7wBQZAD7ZJ_LTOQcRmRaNrGvfZPW_gOT19B-dW-JM7ZrQ0zKxDRVUpaJbxJcmro3nW-bpHV_YMDOhOr395jsOVNHPNm8R-Tl7vZ5Mk0fHu_Lyc1DarmELkWFNquMGw4g447lylVZIVSRUeqAIbNA88rNZOHQCOcwyw2aGVPcCjWT_IicrfsuQvvZY-z03EeLdW0abPuopQSQomADmK9BG9oYAzq9CH5uwremoFcG9a9BvdKj1XBXBjUf6sabAf1sjtW2aqNsyJ9u8iZaU7tgGuvjFlNU5JRlA3a9xnCQsfQYdLQeG4uVD2g7XbX-n0V-AEeTjWA</recordid><startdate>198609</startdate><enddate>198609</enddate><creator>Rosenfeld, Ron G.</creator><creator>Wilson, Darrell M.</creator><creator>Lee, Phillip D.K.</creator><creator>Hintz, Raymond L.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198609</creationdate><title>Insulin-like growth factors I and II in evaluation of growth retardation</title><author>Rosenfeld, Ron G. ; Wilson, Darrell M. ; Lee, Phillip D.K. ; Hintz, Raymond L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-e8ec4dafafa0e23f258fd49689411f02e2c015dfb79fea6ffe45aeab283c68b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Growth Disorders - blood</topic><topic>Humans</topic><topic>Hypothalamus. Hypophysis. Epiphysis (diseases)</topic><topic>Infant</topic><topic>Insulin-Like Growth Factor I - blood</topic><topic>Insulin-Like Growth Factor II - blood</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Somatomedins - blood</topic><topic>Somatomedins - deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenfeld, Ron G.</creatorcontrib><creatorcontrib>Wilson, Darrell M.</creatorcontrib><creatorcontrib>Lee, Phillip D.K.</creatorcontrib><creatorcontrib>Hintz, Raymond L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosenfeld, Ron G.</au><au>Wilson, Darrell M.</au><au>Lee, Phillip D.K.</au><au>Hintz, Raymond L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin-like growth factors I and II in evaluation of growth retardation</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1986-09</date><risdate>1986</risdate><volume>109</volume><issue>3</issue><spage>428</spage><epage>433</epage><pages>428-433</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level <7 ng/ml), 44 normal short children, and 197 children with normal height were asseyed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>3746530</pmid><doi>10.1016/S0022-3476(86)80112-3</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 1986-09, Vol.109 (3), p.428-433 |
| issn | 0022-3476 1097-6833 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Biological and medical sciences Child Child, Preschool Endocrinopathies Female Growth Disorders - blood Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Infant Insulin-Like Growth Factor I - blood Insulin-Like Growth Factor II - blood Male Malignant tumors Medical sciences Somatomedins - blood Somatomedins - deficiency |
| title | Insulin-like growth factors I and II in evaluation of growth retardation |
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