EUS predictors of long-term survival in esophageal carcinoma
Background: EUS is the most accurate nonsurgical modality for the staging of esophageal cancer, but the ability of EUS to predict outcomes or prognosis is unclear. Patients were examined who had EUS performed for esophageal cancer staging to determine which endosonographic features predict survival....
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| Veröffentlicht in: | Gastrointestinal endoscopy 2001-04, Vol.53 (4), p.463-469 |
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| creator | Pfau, Patrick R. Ginsberg, Gregory G. Lew, Ronald J. Brensinger, Colleen M. Kochman, Michael L. |
| description | Background: EUS is the most accurate nonsurgical modality for the staging of esophageal cancer, but the ability of EUS to predict outcomes or prognosis is unclear. Patients were examined who had EUS performed for esophageal cancer staging to determine which endosonographic features predict survival.
Method: Data on 203 patients undergoing EUS for esophageal cancer staging were studied retrospectively. Median survival was calculated for each T-stage and N-stage and according to the presence or absence of celiac axis (CAx) lymphadenopathy as determined by EUS. Kaplan-Meier survival curves were generated for each stage and the log-rank test was used to test for significant differences in survival. Multivariate analysis was performed to test for the relative importance in predicting survival of the EUS stages, also considering age, gender, histology, and type of treatment.
Results: Significant differences were found in the ability of EUS-determined T-stage (
p = 0.0005), N-stage (
p < 0.0001), and presence of CAx nodes (
p = 0.0049) to predict survival. Multivariate analysis showed N-stage to predict survival.
Conclusions: Pretreatment EUS can predict survival in esophageal cancer based on initial T-stage, N-stage, and the presence of CAx nodes. The presence of lymphadenopathy at EUS is an important predictor of survival. EUS should be performed in all patients with esophageal cancer, not only for staging patients before therapy, but also as a valuable method of determining prognosis. (Gastrointest Endosc 2001;53:463-9.) |
| doi_str_mv | 10.1067/mge.2001.113384 |
| format | Article |
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Method: Data on 203 patients undergoing EUS for esophageal cancer staging were studied retrospectively. Median survival was calculated for each T-stage and N-stage and according to the presence or absence of celiac axis (CAx) lymphadenopathy as determined by EUS. Kaplan-Meier survival curves were generated for each stage and the log-rank test was used to test for significant differences in survival. Multivariate analysis was performed to test for the relative importance in predicting survival of the EUS stages, also considering age, gender, histology, and type of treatment.
Results: Significant differences were found in the ability of EUS-determined T-stage (
p = 0.0005), N-stage (
p < 0.0001), and presence of CAx nodes (
p = 0.0049) to predict survival. Multivariate analysis showed N-stage to predict survival.
Conclusions: Pretreatment EUS can predict survival in esophageal cancer based on initial T-stage, N-stage, and the presence of CAx nodes. The presence of lymphadenopathy at EUS is an important predictor of survival. EUS should be performed in all patients with esophageal cancer, not only for staging patients before therapy, but also as a valuable method of determining prognosis. (Gastrointest Endosc 2001;53:463-9.)</description><identifier>ISSN: 0016-5107</identifier><identifier>EISSN: 1097-6779</identifier><identifier>DOI: 10.1067/mge.2001.113384</identifier><identifier>PMID: 11275887</identifier><identifier>CODEN: GAENBQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Carcinoma - diagnostic imaging ; Carcinoma - mortality ; Carcinoma - pathology ; Digestive system. Abdomen ; Esophageal Neoplasms - diagnostic imaging ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Esophagoscopy - methods ; Female ; Forecasting ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate ; Ultrasonic investigative techniques ; Ultrasonography</subject><ispartof>Gastrointestinal endoscopy, 2001-04, Vol.53 (4), p.463-469</ispartof><rights>2001 The American Society for Gastrointestinal Endoscopy</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-5daeda7c418a7e00cf6390ff8a2185863b757e88f6c072cc696bffbc1c313dff3</citedby><cites>FETCH-LOGICAL-c371t-5daeda7c418a7e00cf6390ff8a2185863b757e88f6c072cc696bffbc1c313dff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1067/mge.2001.113384$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=939526$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11275887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pfau, Patrick R.</creatorcontrib><creatorcontrib>Ginsberg, Gregory G.</creatorcontrib><creatorcontrib>Lew, Ronald J.</creatorcontrib><creatorcontrib>Brensinger, Colleen M.</creatorcontrib><creatorcontrib>Kochman, Michael L.</creatorcontrib><title>EUS predictors of long-term survival in esophageal carcinoma</title><title>Gastrointestinal endoscopy</title><addtitle>Gastrointest Endosc</addtitle><description>Background: EUS is the most accurate nonsurgical modality for the staging of esophageal cancer, but the ability of EUS to predict outcomes or prognosis is unclear. Patients were examined who had EUS performed for esophageal cancer staging to determine which endosonographic features predict survival.
Method: Data on 203 patients undergoing EUS for esophageal cancer staging were studied retrospectively. Median survival was calculated for each T-stage and N-stage and according to the presence or absence of celiac axis (CAx) lymphadenopathy as determined by EUS. Kaplan-Meier survival curves were generated for each stage and the log-rank test was used to test for significant differences in survival. Multivariate analysis was performed to test for the relative importance in predicting survival of the EUS stages, also considering age, gender, histology, and type of treatment.
Results: Significant differences were found in the ability of EUS-determined T-stage (
p = 0.0005), N-stage (
p < 0.0001), and presence of CAx nodes (
p = 0.0049) to predict survival. Multivariate analysis showed N-stage to predict survival.
Conclusions: Pretreatment EUS can predict survival in esophageal cancer based on initial T-stage, N-stage, and the presence of CAx nodes. The presence of lymphadenopathy at EUS is an important predictor of survival. EUS should be performed in all patients with esophageal cancer, not only for staging patients before therapy, but also as a valuable method of determining prognosis. (Gastrointest Endosc 2001;53:463-9.)</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - diagnostic imaging</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - pathology</subject><subject>Digestive system. Abdomen</subject><subject>Esophageal Neoplasms - diagnostic imaging</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophagoscopy - methods</subject><subject>Female</subject><subject>Forecasting</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography</subject><issn>0016-5107</issn><issn>1097-6779</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M9LwzAUwPEgipvTszcpCN66Jc2apOBFxvwBAw-6c8heX2akbWbSDfzvzdjQk6cQ8nmP8CXkmtExo0JO2jWOC0rZmDHO1fSEDBmtZC6krE7JMD2IvGRUDshFjJ-UUlVwdk4GjBWyVEoOyf18-ZZtAtYOeh9i5m3W-G6d9xjaLG7Dzu1Mk7kuw-g3H2aN6QYmgOt8ay7JmTVNxKvjOSLLx_n77DlfvD69zB4WOXDJ-rysDdZGwpQpI5FSsIJX1FplCqZKJfhKlhKVsgKoLABEJVbWroABZ7y2lo_I3WHvJvivLcZety4CNo3p0G-jlpJSKQqV4OQAIfgYA1q9Ca414VszqvfBdAqm98H0IViauDmu3q5arP_8sVACt0dgIpjGBtOBi7-u4lVZiKSqg8KUYecw6AgOO0hdA0Kva-_-_cIPvAqGLg</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Pfau, Patrick R.</creator><creator>Ginsberg, Gregory G.</creator><creator>Lew, Ronald J.</creator><creator>Brensinger, Colleen M.</creator><creator>Kochman, Michael L.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>EUS predictors of long-term survival in esophageal carcinoma</title><author>Pfau, Patrick R. ; Ginsberg, Gregory G. ; Lew, Ronald J. ; Brensinger, Colleen M. ; Kochman, Michael L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-5daeda7c418a7e00cf6390ff8a2185863b757e88f6c072cc696bffbc1c313dff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - diagnostic imaging</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - pathology</topic><topic>Digestive system. Abdomen</topic><topic>Esophageal Neoplasms - diagnostic imaging</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophagoscopy - methods</topic><topic>Female</topic><topic>Forecasting</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pfau, Patrick R.</creatorcontrib><creatorcontrib>Ginsberg, Gregory G.</creatorcontrib><creatorcontrib>Lew, Ronald J.</creatorcontrib><creatorcontrib>Brensinger, Colleen M.</creatorcontrib><creatorcontrib>Kochman, Michael L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastrointestinal endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pfau, Patrick R.</au><au>Ginsberg, Gregory G.</au><au>Lew, Ronald J.</au><au>Brensinger, Colleen M.</au><au>Kochman, Michael L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EUS predictors of long-term survival in esophageal carcinoma</atitle><jtitle>Gastrointestinal endoscopy</jtitle><addtitle>Gastrointest Endosc</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>53</volume><issue>4</issue><spage>463</spage><epage>469</epage><pages>463-469</pages><issn>0016-5107</issn><eissn>1097-6779</eissn><coden>GAENBQ</coden><abstract>Background: EUS is the most accurate nonsurgical modality for the staging of esophageal cancer, but the ability of EUS to predict outcomes or prognosis is unclear. Patients were examined who had EUS performed for esophageal cancer staging to determine which endosonographic features predict survival.
Method: Data on 203 patients undergoing EUS for esophageal cancer staging were studied retrospectively. Median survival was calculated for each T-stage and N-stage and according to the presence or absence of celiac axis (CAx) lymphadenopathy as determined by EUS. Kaplan-Meier survival curves were generated for each stage and the log-rank test was used to test for significant differences in survival. Multivariate analysis was performed to test for the relative importance in predicting survival of the EUS stages, also considering age, gender, histology, and type of treatment.
Results: Significant differences were found in the ability of EUS-determined T-stage (
p = 0.0005), N-stage (
p < 0.0001), and presence of CAx nodes (
p = 0.0049) to predict survival. Multivariate analysis showed N-stage to predict survival.
Conclusions: Pretreatment EUS can predict survival in esophageal cancer based on initial T-stage, N-stage, and the presence of CAx nodes. The presence of lymphadenopathy at EUS is an important predictor of survival. EUS should be performed in all patients with esophageal cancer, not only for staging patients before therapy, but also as a valuable method of determining prognosis. (Gastrointest Endosc 2001;53:463-9.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>11275887</pmid><doi>10.1067/mge.2001.113384</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Carcinoma - diagnostic imaging Carcinoma - mortality Carcinoma - pathology Digestive system. Abdomen Esophageal Neoplasms - diagnostic imaging Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Esophagoscopy - methods Female Forecasting Humans Investigative techniques, diagnostic techniques (general aspects) Lymphatic Metastasis Male Medical sciences Middle Aged Prognosis Retrospective Studies Survival Rate Ultrasonic investigative techniques Ultrasonography |
| title | EUS predictors of long-term survival in esophageal carcinoma |
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