Operation and performance of an automatic metaphase finder based on the MRC fast interval processor
The Medical Research Council's fast interval processor (FIP) has been adapted for metaphase finding and selection. This article summarizes recent improvements to the hardware, and describes the selection of image features. The system uses a highly simplified but effective clustering procedure t...
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| Veröffentlicht in: | The journal of histochemistry and cytochemistry 1986-10, Vol.34 (10), p.1245-1252 |
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| container_end_page | 1252 |
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| container_title | The journal of histochemistry and cytochemistry |
| container_volume | 34 |
| creator | Shippey, G Carothers, AD Gordon, J |
| description | The Medical Research Council's fast interval processor (FIP) has been adapted for metaphase finding and selection. This article summarizes recent improvements to the hardware, and describes the selection of image features. The system uses a highly simplified but effective clustering procedure to reduce computation time, and incorporates a ranking algorithm based on computed cluster features so that high-quality metaphases can be preferentially selected. Experimental results indicate that the system can detect high-quality metaphases rapidly in "rich" material and a high proportion of the available metaphases in "sparse" material. It can handle a wide range of material with good repeatability of performance. |
| doi_str_mv | 10.1177/34.10.3755736 |
| format | Article |
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Psychology</subject><subject>Histocytochemistry - instrumentation</subject><subject>Humans</subject><subject>Karyotyping - instrumentation</subject><subject>Lymphocytes - cytology</subject><subject>Metaphase</subject><subject>Molecular and cellular biology</subject><subject>Software</subject><subject>Time Factors</subject><issn>0022-1554</issn><issn>1551-5044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1r3DAQhkVpSbdpjj0WdCgpFJxKlmTZx7KkbSAhEJKzGEujrINtbSS7S_99FGySU07zzswzH7yEfOHsjHOtfwp5lqXQSmlRvSMbrhQvFJPyPdkwVpZFLsiP5FNKD4xxKVV9RI5WfEPs9R4jTF0YKYyO5sSHOMBokQafSxTmKQwZsHTACfY7SEh9NzqMtM3a0Tw57ZBe3WyphzTRbpww_oOe7mOwmFKIn8kHD33CkzUek7vf57fbv8Xl9Z-L7a_LwspSTAUIJyWCY97apq69Vw6hAWDStWWrKw8oBNMcZWvrqlaWtUpr16CXjWwUimNyuuzNlx9nTJMZumSx72HEMCejNWO64nUGiwW0MaQU0Zt97AaI_w1n5tlUI-SzXF3K_Nd18dwO6F7o1_63tQ_JQu9j9q9LL1jNKlFznbEfC5bgHs1DmOOY7Xjz5vcF3nX3u0MX0aQB-j5_wM3hcFhgXkolngAEZZnS</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>Shippey, G</creator><creator>Carothers, AD</creator><creator>Gordon, J</creator><general>Histochemical Soc</general><general>SAGE Publications</general><general>Histochemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861001</creationdate><title>Operation and performance of an automatic metaphase finder based on the MRC fast interval processor</title><author>Shippey, G ; Carothers, AD ; Gordon, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-a3d44ead0fcc988ff5dea9aa04db2b76fae33071e4bc8685c0b577d9ef49495e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Automation</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Cells</topic><topic>Chromosome Banding</topic><topic>Diverse techniques</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histocytochemistry - instrumentation</topic><topic>Humans</topic><topic>Karyotyping - instrumentation</topic><topic>Lymphocytes - cytology</topic><topic>Metaphase</topic><topic>Molecular and cellular biology</topic><topic>Software</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shippey, G</creatorcontrib><creatorcontrib>Carothers, AD</creatorcontrib><creatorcontrib>Gordon, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of histochemistry and cytochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shippey, G</au><au>Carothers, AD</au><au>Gordon, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Operation and performance of an automatic metaphase finder based on the MRC fast interval processor</atitle><jtitle>The journal of histochemistry and cytochemistry</jtitle><addtitle>J Histochem Cytochem</addtitle><date>1986-10-01</date><risdate>1986</risdate><volume>34</volume><issue>10</issue><spage>1245</spage><epage>1252</epage><pages>1245-1252</pages><issn>0022-1554</issn><eissn>1551-5044</eissn><coden>JHCYAS</coden><abstract>The Medical Research Council's fast interval processor (FIP) has been adapted for metaphase finding and selection. 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| identifier | ISSN: 0022-1554 |
| ispartof | The journal of histochemistry and cytochemistry, 1986-10, Vol.34 (10), p.1245-1252 |
| issn | 0022-1554 1551-5044 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77007618 |
| source | MEDLINE; Full-Text Journals in Chemistry (Open access); SAGE Journals Online; EZB Electronic Journals Library |
| subjects | Automation Biological and medical sciences Bone Marrow Cells Chromosome Banding Diverse techniques Fundamental and applied biological sciences. Psychology Histocytochemistry - instrumentation Humans Karyotyping - instrumentation Lymphocytes - cytology Metaphase Molecular and cellular biology Software Time Factors |
| title | Operation and performance of an automatic metaphase finder based on the MRC fast interval processor |
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